Optimizing Drug Outcomes Through Pharmacogenetics: A Case for Preemptive Genotyping von Schildcrout, J S, Denny, J C, Bowton, E, Gregg, W, Pulley, J M, Basford, M A, Cowan, J D, Xu, H, Ramirez, A H, Crawford, D C, Ritchie, M D, Peterson, J F, Masys, D R, Wilke, R A, Roden, D M

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Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network von Bush, WS, Crosslin, DR, Owusu-Obeng, A, Wallace, J, Almoguera, B, Basford, MA, Bielinski, SJ, Carrell, DS, Connolly, JJ, Crawford, D, Doheny, KF, Gallego, CJ, Gordon, AS, Keating, B, Kirby, J, Kitchner, T, Manzi, S, Mejia, AR, Pan, V, Perry, CL, Peterson, JF, Prows, CA, Ralston, J, Scott, SA, Scrol, A, Smith, M, Stallings, SC, Veldhuizen, T, Wolf, W, Volpi, S, Wiley, K, Li, R, Manolio, T, Bottinger, E, Brilliant, MH, Carey, D, Chisholm, RL, Chute, CG, Haines, JL, Hakonarson, H, Harley, JB, Holm, IA, Kullo, IJ, Jarvik, GP, Larson, EB, McCarty, CA, Williams, MS, Denny, JC, Rasmussen-Torvik, LJ, Roden, DM, Ritchie, MD

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Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record von Delaney, J T, Ramirez, A H, Bowton, E, Pulley, J M, Basford, M A, Schildcrout, J S, Shi, Y, Zink, R, Oetjens, M, Xu, H, Cleator, J H, Jahangir, E, Ritchie, M D, Masys, D R, Roden, D M, Crawford, D C, Denny, J C

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Opportunities and challenges for biomarker discovery using electronic health record data von Singhal, P., Tan, A.L.M., Drivas, T.G., Johnson, K.B., Ritchie, M.D., Beaulieu-Jones, B.K.

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Identification of Significant Association and Gene-Gene Interaction of GABA Receptor Subunit Genes in Autism von Ma, D.Q., Whitehead, P.L., Menold, M.M., Martin, E.R., Ashley-Koch, A.E., Mei, H., Ritchie, M.D., DeLong, G.R., Abramson, R.K., Wright, H.H., Cuccaro, M.L., Hussman, J.P., Gilbert, J.R., Pericak-Vance, M.A.

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Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus von CHO, Y. M, RITCHIE, M. D, MOORE, J. H, PARK, J. Y, LEE, K.-U, SHIN, H. D, LEE, H. K, PARK, K. S

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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance) von Chhibber, A, Mefford, J, Stahl, E A, Pendergrass, S A, Baldwin, R M, Owzar, K, Li, M, Winer, E P, Hudis, C A, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, H L, Ratain, M J, Shulman, L N, Ritchie, M D, Plenge, R M, Witte, J S, Kroetz, D L

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A novel method to identify gene-gene effects in nuclear families: the MDR-PDT von Martin, E.R., Ritchie, M.D., Hahn, L., Kang, S., Moore, J.H.

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Drug Transporter and Metabolizing Enzyme Gene Variants and Nonnucleoside Reverse-Transcriptase Inhibitor Hepatotoxicity von Ritchie, Marylyn D., Haas, David W., Motsinger, Alison A., Donahue, John P., Erdem, Huso, Raffanti, Stephen, Rebeiro, Peter, George, Alfred L., Kim, Richard B., Haines, Jonathan L., Sterling, Timothy R.

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Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multicenter Pilot for Preemptive Pharmacogenomics in Electronic Health Record Systems von Rasmussen-Torvik, L J, Stallings, S C, Gordon, A S, Almoguera, B, Basford, M A, Bielinski, S J, Brautbar, A, Brilliant, M H, Carrell, D S, Connolly, J J, Crosslin, D R, Doheny, K F, Gallego, C J, Gottesman, O, Kim, D S, Leppig, K A, Li, R, Lin, S, Manzi, S, Mejia, A R, Pacheco, J A, Pan, V, Pathak, J, Perry, C L, Peterson, J F, Prows, C A, Ralston, J, Rasmussen, L V, Ritchie, M D, Sadhasivam, S, Scott, S A, Smith, M, Vega, A, Vinks, A A, Volpi, S, Wolf, W A, Bottinger, E, Chisholm, R L, Chute, C G, Haines, J L, Harley, J B, Keating, B, Holm, I A, Kullo, I J, Jarvik, G P, Larson, E B, Manolio, T, McCarty, C A, Nickerson, D A, Scherer, S E, Williams, M S, Roden, D M, Denny, J C

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The mitochondrial pharmacogenomics of haplogroup T: MTND2LHON4917G and antiretroviral therapy-associated peripheral neuropathy von Canter, J A, Haas, D W, Kallianpur, A R, Ritchie, M D, Robbins, G K, Shafer, R W, Clifford, D B, Murdock, D G, Hulgan, T

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The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery von Pendergrass, S.A., Brown-Gentry, K., Dudek, S.M., Torstenson, E.S., Ambite, J.L., Avery, C.L., Buyske, S., Cai, C., Fesinmeyer, M.D., Haiman, C., Heiss, G., Hindorff, L.A., Hsu, C.-N., Jackson, R.D., Kooperberg, C., Le Marchand, L., Lin, Y., Matise, T.C., Moreland, L., Monroe, K., Reiner, A.P., Wallace, R., Wilkens, L.R., Crawford, D.C., Ritchie, M.D.

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The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance von Pretorius, M M, Gainer, J V, Van Guilder, G P, Coelho, E B, Luther, J M, Fong, P, Rosenbaum, D D, Malave, H A, Yu, C, Ritchie, M D, Vaughan, D E, Brown, N J

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Genetic variation in the HLA region is associated with susceptibility to herpes zoster von Crosslin, D R, Carrell, D S, Burt, A, Kim, D S, Underwood, J G, Hanna, D S, Comstock, B A, Baldwin, E, de Andrade, M, Kullo, I J, Tromp, G, Kuivaniemi, H, Borthwick, K M, McCarty, C A, Peissig, P L, Doheny, K F, Pugh, E, Kho, A, Pacheco, J, Hayes, M G, Ritchie, M D, Verma, S S, Armstrong, G, Stallings, S, Denny, J C, Carroll, R J, Crawford, D C, Crane, P K, Mukherjee, S, Bottinger, E, Li, R, Keating, B, Mirel, D B, Carlson, C S, Harley, J B, Larson, E B, Jarvik, G P

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tAnGo: a randomised phase III trial of gemcitabine in paclitaxel-containing, epirubicin/cyclophosphamide-based, adjuvant chemotherapy for early breast cancer: a prospective pulmona... von Wardley, A M, Hiller, L, Howard, H C, Dunn, J A, Bowman, A, Coleman, R E, Fernando, I N, Ritchie, D M, Earl, H M, Poole, C J

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Multifactor-Dimensionality Reduction Reveals High-Order Interactions among Estrogen-Metabolism Genes in Sporadic Breast Cancer von Ritchie, Marylyn D., Hahn, Lance W., Roodi, Nady, Bailey, L. Renee, Dupont, William D., Parl, Fritz F., Moore, Jason H.

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Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations von Yoneyama, S, Yao, J, Guo, X, Fernandez-Rhodes, L, Lim, U, Boston, J, Buzková, P, Carlson, C S, Cheng, I, Cochran, B, Cooper, R, Ehret, G, Fornage, M, Gong, J, Gross, M, Gu, C C, Haessler, J, Haiman, C A, Henderson, B, Hindorff, L A, Houston, D, Irvin, M R, Jackson, R, Kuller, L, Leppert, M, Lewis, C E, Li, R, Le Marchand, L, Matise, T C, Nguyen, K-DH, Chakravarti, A, Pankow, J S, Pankratz, N, Pooler, L, Ritchie, M D, Bien, S A, Wassel, C L, Chen, Y-DI, Taylor, K D, Allison, M, Rotter, J I, Schreiner, P J, Schumacher, F, Wilkens, L, Boerwinkle, E, Kooperberg, C, Peters, U, Buyske, S, Graff, M, North, K E

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An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder von Ashley-Koch, A E, Mei, H, Jaworski, J, Ma, D Q, Ritchie, M D, Menold, M M, Delong, G R, Abramson, R K, Wright, H H, Hussman, J P, Cuccaro, M L, Gilbert, J R, Martin, E R, Pericak-Vance, M A

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Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans von Brassat, D, Motsinger, A A, Caillier, S J, Erlich, H A, Walker, K, Steiner, L L, Cree, B A C, Barcellos, L F, Pericak-Vance, M A, Schmidt, S, Gregory, S, Hauser, S L, Haines, J L, Oksenberg, J R, Ritchie, M D

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1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2 von ZHIHUA SUI, JIHUA GUAN, FERRO, M. P, MCCOY, K, WACHTER, M. P, MURRAY, W. V, SINGER, M, STEBER, M, RITCHIE, D. M, ARGENTIERI, D. C

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