Trace Amines: Identification of a Family of Mammalian G Protein-Coupled Receptors von Borowsky, Beth, Adham, Nika, Jones, Kenneth A., Raddatz, Rita, Artymyshyn, Roman, Ogozalek, Kristine L., Durkin, Margaret M., Lakhlani, Parul P., Bonini, James A., Pathirana, Sudam, Boyle, Noel, Pu, Xiaosui, Kouranova, Evguenia, Lichtblau, Harvey, Ochoa, F. Yulina, Branchek, Theresa A., Gerald, Christophe

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Discovery and Characterization of 6-{4-[3-(R)-2-Methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, Irdabisant): A Potent, Selective Histamine H3 Receptor Inverse... von Hudkins, Robert L, Raddatz, Rita, Tao, Ming, Mathiasen, Joanne R, Aimone, Lisa D, Becknell, Nadine C, Prouty, Catherine P, Knutsen, Lars J. S, Yazdanian, Mehran, Moachon, Gilbert, Ator, Mark A, Mallamo, John P, Marino, Michael J, Bacon, Edward R, Williams, Michael

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Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF von Bonini, James A., Jones, Kenneth A., Adham, Nika, Forray, Carlos, Artymyshyn, Roman, Durkin, Margaret M., Smith, Kelli E., Tamm, Joseph A., Boteju, Lakmal W., Lakhlani, Parul P., Raddatz, Rita, Yao, Wen-Jeng, Ogozalek, Kristine L., Boyle, Noel, Kouranova, Evguenia V., Quan, Yong, Vaysse, Pierre J., Wetzel, John M., Branchek, Theresa A., Gerald, Christophe, Borowsky, Beth

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Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): Histamine H3 receptor inverse agonist demonstrating potent cogn... von Hudkins, Robert L., Josef, Kurt A., Becknell, Nadine C., Aimone, Lisa D., Lyons, Jacquelyn A., Mathiasen, Joanne R., Gruner, John A., Raddatz, Rita

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Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System von Raddatz, Rita, Wilson, Amy E., Artymyshyn, Roman, Bonini, James A., Borowsky, Beth, Boteju, Lakmal W., Zhou, Siqun, Kouranova, Evguenia V., Nagorny, Raisa, Guevarra, Maricel S., Dai, Meng, Lerman, Gabriel S., Vaysse, Pierre J., Branchek, Theresa A., Gerald, Christophe, Forray, Carlos, Adham, Nika

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Localization of the Imidazoline Binding Domain on Monoamine Oxidase B von Raddatz, R, Parini, A, Lanier, S M

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Synthesis and structure–activity relationships of 4,5-fused pyridazinones as histamine H 3 receptor antagonists von Tao, Ming, Raddatz, Rita, Aimone, Lisa D., Hudkins, Robert L.

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Analysis of the Pharmacological and Molecular Heterogeneity of I2-Imidazoline-Binding Proteins using Monoamine Oxidase-Deficient Mouse Models von Anne Remaury, Rita Raddatz, Catherine Ordener, Sandra Savic, Jean C. Shih, Kevin Chen, Isabelle Seif, Edward De Maeyer, Stephen M. Lanier, Angelo Parini

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Optimization of 5-Pyridazin-3-one Phenoxypropylamines as Potent, Selective Histamine H 3 Receptor Antagonists with Potent Cognition Enhancing Activity von Tao, Ming, Aimone, Lisa D., Huang, Zeqi, Mathiasen, Joanne, Raddatz, Rita, Lyons, Jacquelyn, Hudkins, Robert L.

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CEP-26401 (Irdabisant), a Potent and Selective Histamine H 3 Receptor Antagonist/Inverse Agonist with Cognition-Enhancing and Wake-Promoting Activities von Raddatz, Rita, Hudkins, Robert L., Mathiasen, Joanne R., Gruner, John A., Flood, Dorothy G., Aimone, Lisa D., Le, Siyuan, Schaffhauser, Hervé, Duzic, Emir, Gasior, Maciej, Bozyczko-Coyne, Donna, Marino, Michael J., Ator, Mark A., Bacon, Edward R., Mallamo, John P., Williams, Michael

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3-(1'-Cyclobutylspiro[4H-1,3-benzodioxine-2,4'-piperidin e]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H sub(3) antagonist/inverse ag... von Hudkins, Robert L, Gruner, John A, Raddatz, Rita, Mathiasen, Joanne R, Aimone, Lisa D, Marino, Michael J, Bacon, Edward R, Williams, Michael, Ator, Mark A

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Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bi c yclo[4.1.0]hept-4-en-2-one (R,S-4a): Histamine H3 receptor inverse agonist demonstrating potent co... von Hudkins, Robert, Josef, Kurt, Becknell, Nadine, Aimone, Lisa, Lyons, Jacquelyn, Mathiasen, Joanne, Gruner, John, Raddatz, Rita

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Discovery and characterization of GPR6 inverse agonists (1144.11) von Wood, Michael, Tanaka, Shigeru, Ryberg, Erik, Norris, Tyrrell, Hastings, Richard, Bostwick, James, Greasley, Peter, Raddatz, Rita, Sakai, Norio, Cross, Alan

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Synthesis and evaluation of pyridone-phenoxypropyl- R-2-methylpyrrolidine analogues as histamine H 3 receptor antagonists von Becknell, Nadine C., Lyons, Jacquelyn A., Aimone, Lisa D., Gruner, John A., Mathiasen, Joanne R., Raddatz, Rita, Hudkins, Robert L.

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3-(1′-Cyclobutylspiro[4H-1,3-benzodioxine-2,4′-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist... von Hudkins, Robert L., Gruner, John A., Raddatz, Rita, Mathiasen, Joanne R., Aimone, Lisa D., Marino, Michael J., Bacon, Edward R., Williams, Michael, Ator, Mark A.

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Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H sub(3 receptor antagonists) von Tao, Ming, Raddatz, Rita, Aimone, Lisa D, Hudkins, Robert L

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Allosteric approaches to the targeting of G-protein-coupled receptors for novel drug discovery: A critical assessment von Raddatz, Rita, Schaffhauser, Hervé, Marino, Michael J.

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Amine-constrained pyridazinone histamine H3 receptor antagonists von Sundar, Babu G., Bailey, Thomas, Bacon, Edward, Aimone, Lisa, Huang, Zeqi, Lyons, Jacquelyn, Raddatz, Rita, Hudkins, Robert

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3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity von Hudkins, Robert L., Becknell, Nadine C., Lyons, Jacquelyn A., Aimone, Lisa D., Olsen, Mark, Haltiwanger, R. Curtis, Mathiasen, Joanne R., Raddatz, Rita, Gruner, John A.

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Synthesis and evaluation of pyridazinone–phenethylamine derivatives as selective and orally bioavailable histamine H 3 receptor antagonists with robust wake-promoting activity von Dandu, Reddeppa reddy, Gruner, John A., Mathiasen, Joanne R., Aimone, Lisa D., Hostetler, Greg, Benfield, Caitlyn, Bendesky, Robert J., Marcy, Val R., Raddatz, Rita, Hudkins, Robert L.

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