PO-180 InfiltratingCD8 + T-cells and PD-L1 expression as indicators for immunotherapy in sinonasal cancer von López, F., García-Marín, R., Suárez-Fernández, L., Naves-Cabal, V., Riobello, C., Reda, S., Hermsen, M., Llórente, J.L.

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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway von Fondevila, Marcos F., Novoa, Eva, Gonzalez-Rellan, Maria J., Fernandez, Uxia, Heras, Violeta, Porteiro, Begoña, Parracho, Tamara, Dorta, Valentina, Riobello, Cristina, da Silva Lima, Natalia, Seoane, Samuel, Garcia-Vence, Maria, Chantada-Vazquez, Maria P., Bravo, Susana B., Senra, Ana, Leiva, Magdalena, Marcos, Miguel, Sabio, Guadalupe, Perez-Fernandez, Roman, Dieguez, Carlos, Prevot, Vincent, Schwaninger, Markus, Woodhoo, Ashwin, Martinez-Chantar, Maria L., Schwabe, Robert, Cubero, Francisco J., Varela-Rey, Marta, Crespo, Javier, Iruzubieta, Paula, Nogueiras, Ruben

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Next-generation sequencing for identification of actionable gene mutations in intestinal-type sinonasal adenocarcinoma von Sánchez-Fernández, Paula, Riobello, Cristina, Costales, María, Vivanco, Blanca, Cabal, Virginia N., García-Marín, Rocío, Suárez-Fernández, Laura, López, Fernando, Cabanillas, Rubén, Hermsen, Mario A., Llorente, José Luis

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Programmed death ligand‐1 expression as immunotherapeutic target in sinonasal cancer von Riobello, Cristina, Vivanco, Blanca, Reda, Sara, López‐Hernández, Alejandro, García‐Inclán, Cristina, Potes‐Ares, Sira, Cabal, Virginia N., López, Fernando, Llorente, José Luis, Hermsen, Mario A.

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Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism von Gonzalez-Rellan, María J, Fernández, Uxía, Parracho, Tamara, Novoa, Eva, Fondevila, Marcos F, da Silva Lima, Natalia, Ramos, Lucía, Rodríguez, Amaia, Serrano-Maciá, Marina, Perez-Mejias, Gonzalo, Chantada-Vazquez, Pilar, Riobello, Cristina, Veyrat-Durebex, Christelle, Tovar, Sulay, Coppari, Roberto, Woodhoo, Ashwin, Schwaninger, Markus, Prevot, Vincent, Delgado, Teresa C, Lopez, Miguel, Diaz-Quintana, Antonio, Dieguez, Carlos, Guallar, Diana, Frühbeck, Gema, Diaz-Moreno, Irene, Bravo, Susana B, Martinez-Chantar, Maria L, Nogueiras, Ruben

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GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells von da Silva Lima, Natália, Cabaleiro, Alba, Novoa, Eva, Riobello, Cristina, Knerr, Patrick J., He, Yantao, Esquinas-Román, Eva M., González-García, Ismael, Prevot, Vincent, Schwaninger, Markus, Dieguez, Carlos, López, Miguel, Müller, Timo D., Varela-Rey, Marta, Douros, Jonathan D., Nogueiras, Ruben

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Translational genomics of sinonasal cancers von Hermsen, Mario A., Riobello, Cristina, García-Marín, Rocío, Cabal, Virginia N., Suárez-Fernández, Laura, López, Fernando, Llorente, José L.

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Mismatch Repair Deficiency and Somatic Mutations in Human Sinonasal Tumors von Hieggelke, Lena, Heydt, Carina, Castiglione, Roberta, Rehker, Jan, Merkelbach-Bruse, Sabine, Riobello, Cristina, Llorente, José Luis, Hermsen, Mario A., Buettner, Reinhard

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CD8 + Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma von García-Marín, Rocío, Reda, Sara, Riobello, Cristina, Cabal, Virginia N, Suárez-Fernández, Laura, Vivanco, Blanca, López, Fernando, Llorente, José L, Hermsen, Mario A

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Characterization of a Preclinical In Vitro Model Derived from a SMARCA4-Mutated Sinonasal Teratocarcinosarcoma von Lorenzo-Guerra, Sara Lucila, Codina-Martínez, Helena, Suárez-Fernández, Laura, Cabal, Virginia N, García-Marín, Rocío, Riobello, Cristina, Vivanco, Blanca, Blanco-Lorenzo, Verónica, Sánchez-Fernández, Paula, López, Fernando, Llorente, Jóse Luis, Hermsen, Mario A

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Prognostic and Therapeutic Implications of Immune Classification by CD8+ Tumor-Infiltrating Lymphocytes and PD-L1 Expression in Sinonasal Squamous Cell Carcinoma von García-Marín, Rocío, Reda, Sara, Riobello, Cristina, Cabal, Virginia N., Suárez-Fernández, Laura, Vivanco, Blanca, Álvarez-Marcos, César, López, Fernando, Llorente, José L., Hermsen, Mario A.

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Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting von Capelo-Diz, Alba, Lachiondo-Ortega, Sofía, Fernández-Ramos, David, Cañas-Martín, Jorge, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, González-Rellan, Maria J, Mosca, Laura, Blazquez-Vicens, Joan, Tinahones-Ruano, Alberto, Fondevila, Marcos F, Buyan, Mason, Delgado, Teresa C, Gutierrez de Juan, Virginia, Ayuso-García, Paula, Sánchez-Rueda, Alejandro, Velasco-Avilés, Sergio, Fernández-Susavila, Héctor, Riobello-Suárez, Cristina, Dziechciarz, Bartlomiej, Montiel-Duarte, Cristina, Lopitz-Otsoa, Fernando, Bizkarguenaga, Maider, Bilbao-García, Jon, Bernardo-Seisdedos, Ganeko, Senra, Ana, Soriano-Navarro, Mario, Millet, Oscar, Díaz-Lagares, Ángel, Crujeiras, Ana B, Bao-Caamano, Aida, Cabrera, Diana, van Liempd, Sebastiaan, Tamayo-Carro, Miguel, Borzacchiello, Luigi, Gomez-Santos, Beatriz, Buqué, Xabier, Sáenz de Urturi, Diego, González-Romero, Francisco, Simon, Jorge, Rodríguez-Agudo, Rubén, Ruiz, Asier, Matute, Carlos, Beiroa, Daniel, Falcon-Perez, Juan M, Aspichueta, Patricia, Rodríguez-Cuesta, Juan, Porcelli, Marina, Pajares, María A, Ameneiro, Cristina, Fidalgo, Miguel, Aransay, Ana M, Lama-Díaz, Tomas, Blanco, Miguel G, López, Miguel, Villa-Bellosta, Ricardo, Müller, Timo D, Nogueiras, Rubén, Woodhoo, Ashwin, Martínez-Chantar, María Luz, Varela-Rey, Marta

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Next‐generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal‐type sinonasal adenocarcinoma von Riobello, Cristina, Sánchez‐Fernández, Paula, Córdoba, María Camila Cubides, González‐Gutiérrez, Maripaz, Vivanco, Blanca, Cabal, Virginia N., Fernández, Laura Suárez, García‐Marín, Rocío, Codina‐Martínez, Helena, Lorenzo‐Guerra, Sara Lucila, López, Fernando, Hermsen, Mario A., Llorente, José Luis

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Genetic profiling of poorly differentiated sinonasal tumours von López-Hernández, Alejandro, Vivanco, Blanca, Franchi, Alessandro, Bloemena, Elisabeth, Cabal, Virginia N., Potes, Sira, Riobello, Cristina, García-Inclán, Cristina, López, Fernando, Llorente, José L., Hermsen, Mario

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A Novel External Auditory Canal Squamous Cell Carcinoma Cell Line Sensitive to CDK4/6 Inhibition von García‐Marín, Rocío, Cabal, Virginia N., Fernández‐Cedrón Bermejo, Carmen, Riobello, Cristina, Suárez‐Fernández, Laura, Codina‐Martínez, Helena, Navarro‐García, Ainhoa, Lorenzo‐Guerra, Sara Lucila, García‐Martínez, Jorge, Vivanco, Blanca, López, Fernando, Llorente, José Luis, Hermsen, Mario A.

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Genomic profiling of intestinal‐type sinonasal adenocarcinoma reveals subgroups of patients with distinct clinical outcomes von López‐Hernández, Alejandro, Pérez‐Escuredo, Jhudit, Vivanco, Blanca, García‐Inclán, Cristina, Potes‐Ares, Sira, Cabal, Virginia N., Riobello, Cristina, Costales, María, López, Fernando, Llorente, José Luis, Hermsen, Mario A.

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Intragenic NF1 deletions in sinonasal mucosal malignant melanoma von Riobello, Cristina, Casanueva Muruais, Rodrigo, Suárez‐Fernández, Laura, García‐Marín, Rocío, Cabal, Virginia N., Blanco‐Lorenzo, Verónica, Franchi, Alessandro, Laco, Jan, López, Fernando, Llorente, José Luis, Hermsen, Mario A.

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Aberrant Signaling Pathways in Sinonasal Intestinal-Type Adenocarcinoma von Riobello, Cristina, Sánchez-Fernández, Paula, Cabal, Virginia N., García-Marín, Rocío, Suárez-Fernández, Laura, Vivanco, Blanca, Blanco-Lorenzo, Verónica, Álvarez Marcos, César, López, Fernando, Llorente, José Luis, Hermsen, Mario A.

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Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination von Ayuso-García, Paula, Sánchez-Rueda, Alejandro, Velasco-Avilés, Sergio, Tamayo-Caro, Miguel, Ferrer-Pinós, Aroa, Huarte-Sebastian, Cecilia, Alvarez, Vanesa, Riobello, Cristina, Jiménez-Vega, Selene, Buendia, Izaskun, Cañas-Martin, Jorge, Fernández-Susavila, Héctor, Aparicio-Rey, Adrián, Esquinas-Román, Eva M, Ponte, Carlos Rodríguez, Guhl, Romane, Laville, Nicolas, Pérez-Andrés, Encarni, Lavín, José L, González-Lopez, Monika, Cámara, Nuria Macías, Aransay, Ana M, Lozano, Juan José, Sutherland, James D, Barrio, Rosa, Martinez-Chantar, María Luz, Azkargorta, Mikel, Elortza, Félix, Soriano-Navarro, Mario, Matute, Carlos, Sánchez-Gómez, María Victoria, Bayón-Cordero, Laura, Pérez-Samartín, Alberto, Bravo, Susana B, Kurz, Thimo, Lama-Díaz, Tomas, Blanco, Miguel G, Haddad, Saif, Record, Christopher J, van Hasselt, Peter M, Reilly, Mary M, Varela-Rey, Marta, Woodhoo, Ashwin

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Experimental Models of Sinonasal Tumors for Preclinical Testing of Candidate Targeted Therapies von Codina-Martínez, Helena, Lorenzo-Guerra, Sara Lucila, Cabal, Virginia N., García-Marín, Rocío, Riobello, Cristina, Suárez-Fernández, Laura, Vivanco, Blanca, Blanco-Lorenzo, Verónica, López, Fernando, Sánchez-Fernández, Paula, Hermsen, Mario A., Llorente, José Luis

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