Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors von Rimkus, Tadas K, Carpenter, Richard L, Qasem, Shadi, Chan, Michael, Lo, Hui-Wen

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TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment von Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Regua, Angelina T., Arrigo, Austin, Anguelov, Marlyn, Pasche, Boris, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen

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Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44 von Rimkus, Tadas K, Carpenter, Richard L, Sirkisoon, Sherona, Zhu, Dongqin, Pasche, Boris C, Chan, Michael D, Lesser, Glenn J, Tatter, Stephen B, Watabe, Kounosuke, Debinski, Waldemar, Lo, Hui-Wen

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NEDD4 degrades TUSC2 to promote glioblastoma progression von Rimkus, Tadas K., Arrigo, Austin B., Zhu, Dongqin, Carpenter, Richard L., Sirkisoon, Sherona, Doheny, Daniel, Regua, Angelina T., Wong, Grace L., Manore, Sara, Wagner, Calvin, Lin, Hui-Kuan, Jin, Guangxu, Ruiz, Jimmy, Chan, Michael, Debinski, Waldemar, Lo, Hui-Wen

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Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth von Carpenter, Richard L, Sirkisoon, Sherona, Zhu, Dongqin, Rimkus, Tadas, Harrison, Alexandria, Anderson, Ashley, Paw, Ivy, Qasem, Shadi, Xing, Fei, Liu, Yin, Chan, Michael, Metheny-Barlow, Linda, Pasche, Boris C, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen

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Abstract 3342: Truncated glioma-associated oncogene homolog 1 (tGLI1) is a novel mediator of mesenchymal subtype of glioblastoma and a novel transcriptional activator of CD44 von Rimkus, Tadas K.

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Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer von Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Anderson, Ashley, Harrison, Alexandria, Lange, Allison M., Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen

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Correction: Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer von Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Anderson, Ashley, Harrison, Alexandria, Lange, Allison M., Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen

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Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers von Rimkus, Tadas, Sirkisoon, Sherona, Harrison, Alexandra, Lo, Hui-Wen

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Abstract 2866: Truncated glioma-associated oncogene homolog 1 (tGLI1) is an actionable therapeutic target in breast cancer brain metastases von Doheny, Daniel L., Sirkisoon, Sherona R., Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah R., Anguelov, Marlyn, Manore, Sara, Xing, Fei, Metheny-Barlow, Linda, Watabe, Kounosuke, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy E., Lo, Hui-Wen

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Abstract 5025: Antifungal ketoconazole inhibits tumor-specific transcription factor tGLI1 leading to suppression of breast cancer stem cells and brain metastasis von Doheny, Daniel L., Sirkisoon, Sherona R., Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah R., Harrison, Alexandria, Anguelov, Marlyn, Manore, Sara, Xing, Fei, Metheny-Barlow, Linda J., Watabe, Kounosuke, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen

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Correction: TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment von Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Regua, Angelina T., Arrigo, Austin, Anguelov, Marlyn, Pasche, Boris, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen

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Abstract 5415: STAT3 and GLI1/tGLI1 oncogenic transcription factors interact to promote the aggressiveness of triple-negative and HER2-enriched breast cancers von Sirkisoon, Sherona R., Carpenter, Richard L., Tadas, Rimkus, Ashley, Anderson, Harrison, Alexandria, Lange, Allison M., Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen

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Abstract 3481: Roles of tumor suppressor candidate 2 (TUSC2) in glioblastoma progression and gliomagenesis von Rimkus, Tadas K., Zhu, Dongqin, Carpenter, Richard L., Paw, Ivy, Arrigo, Austin, Sirkisoon, Sherona, Doheny, Daniel, Aguayo, Noah, Lee, Jingyun, Jin, Guangxu, Spooner, Eric, Pasche, Boris, Debinski, Waldemar, Lo, Hui-Wen

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Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative and HER2-enriched breast cancers von Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Anderson, Ashley, Harrison, Alexandria, Lange, Allison M., Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen

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Abstract 3689: Tumor-specific gain-of-function tGLI1 transcription factor is a novel mediator of breast cancer stem cells and a novel transcriptional activator of cancer stemness g... von Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Anguelov, Marlyn, Arrigo, Austin, Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Pasche, Boris C., Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen

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54. tGLI1 IS AN ACTIONABLE THERAPEUTIC TARGET IN BREAST CANCER BRAIN METASTASES von Doheny, Daniel, Sirkisoon, Sherona, Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah, Anguelov, Marlyn, Manore, Sara, Regua, Angelina, Thomas, Alexandra, Henson-Masters, Adrianna, Strowd, Roy, Lo, Hui-Wen

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BSCI-14. tGLI1 is an actionable therapeutic target in breast cancer brain metastases von Doheny, Daniel, Manore, Sara, Wong, Grace, Zhu, Dongqin, Sirkisoon, Sherona, Rimkus, Tadas, Anguelov, Marlyn, Aguayo, Noah, Regua, Angelina, Cox, Anderson O’Brian, Furdui, Cristina, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen

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BSCI-13. TUMOR-SPECIFIC tGLI1 TRANSCRIPTION FACTOR MEDIATES BREAST CANCER BRAIN METASTASIS VIA ACTIVATING METASTASIS-INITIATING CANCER STEM CELLS AND ASTROCYTES IN THE TUMOR MICROE... von Sirkisoon, Sherona, Carpenter, Richard, Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah, Anguelov, Marlyn, Arrigo, Austin, Regua, Angelina, Xing, Fei, Chan, Michael, Metheny-Barlow, Linda, Watabe, Kounosuke, Lo, Hui-Wen

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BSCI-02. tGLI1 IS A NOVEL, ACTIONABLE TARGET FOR THE TREATMENT OF BREAST CANCER BRAIN METASTASES von Doheny, Daniel, Sirkisoon, Sherona, Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah, Harrison, Alexandria, Anguelov, Marlyn, Xing, Fei, Metheny-Barlow, Linda, Watabe, Kounosuke, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen

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