Structure-based design of aliskiren, a novel orally effective renin inhibitor von Wood, Jeanette M, Maibaum, Jürgen, Rahuel, Joseph, Grütter, Markus G, Cohen, Nissim-Claude, Rasetti, Vittorio, Rüger, Heinrich, Göschke, Richard, Stutz, Stefan, Fuhrer, Walter, Schilling, Walter, Rigollier, Pascal, Yamaguchi, Yasuchika, Cumin, Frederic, Baum, Hans-Peter, Schnell, Christian R, Herold, Peter, Mah, Robert, Jensen, Chris, O’Brien, Eoin, Stanton, Alice, Bedigian, Martin P

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Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides:  The Discovery of Aliskiren, a Potent Nonpeptide Human R... von Maibaum, Jürgen, Stutz, Stefan, Göschke, Richard, Rigollier, Pascal, Yamaguchi, Yasuchika, Cumin, Frédéric, Rahuel, Joseph, Baum, Hans-Peter, Cohen, Nissim-Claude, Schnell, Christian R, Fuhrer, Walter, Gruetter, Markus G, Schilling, Walter, Wood, Jeanette M

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors von Velcicky, Juraj, Mathison, Casey J. N, Nikulin, Victor, Pflieger, Daniel, Epple, Robert, Azimioara, Mihai, Cow, Christopher, Michellys, Pierre-Yves, Rigollier, Pascal, Beisner, Daniel R, Bodendorf, Ursula, Guerini, Danilo, Liu, Bo, Wen, Ben, Zaharevitz, Samantha, Brandl, Trixi

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Fragment-Based Screening by Biochemical Assays: Systematic Feasibility Studies with Trypsin and MMP12 von Boettcher, Andreas, Ruedisser, Simon, Erbel, Paulus, Vinzenz, Daniela, Schiering, Nikolaus, Hassiepen, Ulrich, Rigollier, Pascal, Mayr, Lorenz M., Woelcke, Julian

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Novel 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin von Göschke, Richard, Stutz, Stefan, Rasetti, Vittorio, Cohen, Nissim-Claude, Rahuel, Joseph, Rigollier, Pascal, Baum, Hans-Peter, Forgiarini, Peter, Schnell, Christian R, Wagner, Trixie, Gruetter, Markus G, Fuhrer, Walter, Schilling, Walter, Cumin, Frédéric, Wood, Jeanette M, Maibaum, Jürgen

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A facile synthesis of novel 2-amino-6-arylmethyl-7-carboxamido-7,8-dihydropyrimido[5,4- f][1,4]thiazepin-5-ones von Qin, Lan-Ying, Cole, Andrew G., Metzger, Axel, Brescia, Marc-Raleigh, Saionz, Kurt W., Zhang, Joan J., Rigollier, Pascal, Wareing, James R., Gstach, Hubert, Zimmermann, Juerg, Dolle, Roland E., Baldwin, John J., Henderson, Ian

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PCTA DERIVATIVES, CONJUGATES THEREOF AND USES THEREOF von EHRHARDT, Claus, HOLZER, Philipp, BRIARD, Emmanuelle, RIGOLLIER, Pascal

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Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neur... von Rueeger, Heinrich, Gerspacher, Marc, Buehlmayer, Peter, Rigollier, Pascal, Yamaguchi, Yasuchika, Schmidlin, Tibur, Whitebread, Steven, Nuesslein-Hildesheim, Barbara, Nick, Hanspeter, Cricione, Leoluca

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COMPOUNDS AND COMPOSITIONS AS SPPL2A INHIBITORS von EHRHARDT, Claus, VELCICKY, Juraj, BRANDL, Trixi, EPPLE, Robert, MARKERT, Christian, RIGOLLIER, Pascal

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COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS von Epple, Robert, Brandl, Trixi, Markert, Christian, Rigollier, Pascal, Velcicky, Juraj, Ehrhardt, Claus

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COMPOUNDS AND COMPOSITIONS AS SPPL2A INHIBITORS von EHRHARDT, Claus, VELCICKY, Juraj, BRANDL, Trixi, EPPLE, Robert, MARKERT, Christian, RIGOLLIER, Pascal

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COMPOUNDS AND COMPOSITIONS AS SPPL2A INHIBITORS von EHRHARDT, Claus, VELCICKY, Juraj, BRANDL, Trixi, EPPLE, Robert, MARKERT, Christian, RIGOLLIER, Pascal

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Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists von RUEEGER, H, RIGOLLIER, P, ISLAM, I, ZHANG, J, GLUCHOWSKI, C, YAMAGUCHI, Y, SCHMIDLIN, T, SCHILLING, W, CRISCIONE, L, WHITEBREAD, S, CHIESI, M, WALKER, M. W, DHANOA, D

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PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS von WILCKEN, Rainer, GERSPACHER, Marc, WARIN, Nicolas, LORTHIOIS, Edwige Liliane Jeanne, VAUPEL, Andrea, LIU, Bo, RIGOLLIER, Pascal, MACHAUER, Rainer, MURA, Christophe, COTESTA, Simona, MAH, Robert, STUTZ, Stefan, SCHNEIDER, Nadine, LEBLANC, Catherine

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PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS von Machauer, Rainer, Cotesta, Simona, Mura, Christophe, Leblanc, Catherine, Rigollier, Pascal, Warin, Nicolas, Gerspacher, Marc, Liu, Bo, Stutz, Stefan, Vaupel, Andrea, Schneider, Nadine, Lorthiois, Edwige Liliane Jeanne, Mah, Robert, Wilcken, Rainer

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PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS von MAH, ROBERT, RIGOLLIER, PASCAL, WILCKEN, RAINER, LEBLANC, CATHERINE, VAUPEL, ANDREA, COTESTA, SIMONA, MURA, CHRISTOPHE, GERSPACHER, MARC, WARIN, NICOLAS, MACHAUER, RAINER, SCHNEIDER, NADINE, STUTZ, STEFAN, LIU, BO, LORTHIOIS, EDWIGE LILIANE JEANNE

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Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4 H-3-thia-1-aza-benzo[ e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[ e]azulen derivatives as n... von Rueeger, Heinrich, Gerspacher, Marc, Buehlmayer, Peter, Rigollier, Pascal, Yamaguchi, Yasuchika, Schmidlin, Tibur, Whitebread, Steven, Nuesslein-Hildesheim, Barbara, Nick, Hanspeter, Cricione, Leoluca

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Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-this-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-this-1-aza-benzo[e]azulen derivatives as neur... von RUEEGER, Heinrich, GERSPACHER, Marc, BUEHLMAYER, Peter, RIGOLLIER, Pascal, YAMAGUCHI, Yasuchika, SCHMIDLIN, Tibur, WHITEBREAD, Steven, NUESSLEIN-HILDESHEIM, Barbara, NICK, Hanspeter, CRICIONE, Leoluca

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