Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas von Mount, Christopher W., Majzner, Robbie G., Sundaresh, Shree, Arnold, Evan P., Kadapakkam, Meena, Haile, Samuel, Labanieh, Louai, Hulleman, Esther, Woo, Pamelyn J., Rietberg, Skyler P., Vogel, Hannes, Monje, Michelle, Mackall, Crystal L.

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CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors von Majzner, Robbie G, Theruvath, Johanna L, Nellan, Anandani, Heitzeneder, Sabine, Cui, Yongzhi, Mount, Christopher W, Rietberg, Skyler P, Linde, Miles H, Xu, Peng, Rota, Christopher, Sotillo, Elena, Labanieh, Louai, Lee, Daniel W, Orentas, Rimas J, Dimitrov, Dimiter S, Zhu, Zhongyu, Croix, Brad St, Delaidelli, Alberto, Sekunova, Alla, Bonvini, Ezio, Mitra, Siddhartha S, Quezado, Martha M, Majeti, Ravindra, Monje, Michelle, Sorensen, Poul H B, Maris, John M, Mackall, Crystal L

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Co-opting signalling molecules enables logic-gated control of CAR T cells von Tousley, Aidan M., Rotiroti, Maria Caterina, Labanieh, Louai, Rysavy, Lea Wenting, Kim, Won-Ju, Lareau, Caleb, Sotillo, Elena, Weber, Evan W., Rietberg, Skyler P., Dalton, Guillermo Nicolas, Yin, Yajie, Klysz, Dorota, Xu, Peng, de la Serna, Eva L., Dunn, Alexander R., Satpathy, Ansuman T., Mackall, Crystal L., Majzner, Robbie G.

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Tuning the Antigen Density Requirement for CAR T-cell Activity von Majzner, Robbie G., Rietberg, Skyler P., Sotillo, Elena, Dong, Rui, Vachharajani, Vipul T., Labanieh, Louai, Myklebust, June H., Kadapakkam, Meena, Weber, Evan W., Tousley, Aidan M., Richards, Rebecca M., Heitzeneder, Sabine, Nguyen, Sang M., Wiebking, Volker, Theruvath, Johanna, Lynn, Rachel C., Xu, Peng, Dunn, Alexander R., Vale, Ronald D., Mackall, Crystal L.

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Programmed cell death protein 1 activation preferentially inhibits CD28.CAR–T cells von Zolov, Sergey N, Rietberg, Skyler P, Bonifant, Challice L

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Immune receptor inhibition through enforced phosphatase recruitment von Fernandes, Ricardo A., Su, Leon, Nishiga, Yoko, Ren, Junming, Bhuiyan, Aladdin M., Cheng, Ning, Kuo, Calvin J., Picton, Lora K., Ohtsuki, Shozo, Majzner, Robbie G., Rietberg, Skyler P., Mackall, Crystal L., Yin, Qian, Ali, Lestat R., Yang, Xinbo, Savvides, Christina S., Sage, Julien, Dougan, Michael, Garcia, K. Christopher

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Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas von Monje, Michelle, Mahdi, Jasia, Majzner, Robbie, Yeom, Kristen W., Schultz, Liora M., Richards, Rebecca M., Barsan, Valentin, Song, Kun-Wei, Kamens, Jen, Baggott, Christina, Kunicki, Michael, Rietberg, Skyler P., Lim, Alexandria Sung, Reschke, Agnes, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Patel, Shabnum, Chinnasamy, Harshini, Erickson, Courtney, Jacobs, Ashley, Duh, Allison K., Tunuguntla, Ramya, Klysz, Dorota Danuta, Fowler, Carley, Green, Sean, Beebe, Barbara, Carr, Casey, Fujimoto, Michelle, Brown, Annie Kathleen, Petersen, Ann-Louise G., McIntyre, Catherine, Siddiqui, Aman, Lepori-Bui, Nadia, Villar, Katlin, Pham, Kymhuynh, Bove, Rachel, Musa, Eric, Reynolds, Warren D., Kuo, Adam, Prabhu, Snehit, Rasmussen, Lindsey, Cornell, Timothy T., Partap, Sonia, Fisher, Paul G., Campen, Cynthia J., Grant, Gerald, Prolo, Laura, Ye, Xiaobu, Sahaf, Bita, Davis, Kara L., Feldman, Steven A., Ramakrishna, Sneha, Mackall, Crystal

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Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury von McHugh, Walker M, Russell, William W, Fleszar, Andrew J, Rodenhouse, Paul E, Rietberg, Skyler P, Sun, Lei, Shanley, Thomas P, Cornell, Timothy T

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IMMU-60. MYELOID POPULATIONS MODULATE GD2 CAR T CELL ACTIVITY IN DIFFUSE MIDLINE GLIOMA von Ramakrishna, Sneha, Geraghty, Anna, Good, Zinaida, Desai, Moksha, Mancusi, Rebecca, Mahdi, Jasia, Song, Kun Wei, Ehlinger, Zachary, Chen, Yiyun, Hamilton, Mark, Rietberg, Skyler, Majzner, Robbie, Schultz, Liora, Richards, Becky, Kamens, Jennifer, Barsan, Vali, Campen, Cynthia, Partap, Sonia, Moon, Jennifer, Baggott, Christina, Kunick, Michael, Fujimoto, Michelle, Li, Amy, Jariwala, Sneha, Mavroukakis, Sharon, Egeler, Emily, Jacobs, Ashley, Erickson, Courtney, Prabhu, Snehit, Davis, Kara, Feldman, Steven, Sahaf, Bita, Mackall, Crystal, Monje, Michelle

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Abstract 958: Anti-GD2 chimeric antigen receptor T cells as a potent immunotherapy regimen in xenograft models of histone 3 K27M mutant diffuse midline glioma von Mount, Christopher W., Majzner, Robbie, Sundaresh, Shree, Arnold, Evan P., Kadapakkam, Meena, Haile, Samuel, Labanieh, Louai, Woo, Pamelyn, Rietberg, Skyler P., Vogel, Hannes, Monje, Michelle, Mackall, Crystal L.

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DIPG-47. SEQUENTIAL INTRAVENOUS AND INTRACEREBROVENTRICULAR GD2-CAR T-CELL THERAPY FOR H3K27M-MUTATED DIFFUSE MIDLINE GLIOMAS von Monje, Michelle, Mahdi, Jasia, Majzner, Robbie G, Yeom, Kristen, Schultz, Liora M, Richards, Rebecca, Barsan, Valentin, Song, Kun-Wei, Kamens, Jennifer, Baggott, Christina, Kunicki, Michael, Lim, Alexandria Sung, Reschke, Agnes, Mavroukakis, Sharon, Egeler, Emily, Moon, Jennifer, Patel, Shabnum, Chinnasamy, Harshini, Erickson, Courtney, Jacobs, Ashley, Duh, Allison K, Rietberg, Skyler P, Tunuguntla, Ramya, Klysz, Dorota Danuta, Fowler, Carley, Green, Sean, Beebe, Barbara, Carr, Casey, Fujimoto, Michelle, Brown, Annie Kathleen, Peterson, Ann-Louise G, McIntyre, Catherine, Siddiqui, Aman, Lepori-Bui, Nadia, Villar, Katlin, Pham, Kymhuynh, Bove, Rachel, Musa, Eric, Reynolds, Warren, Kuo, Adam, Prabhu, Snehit, Rasmussen, Lindsey, Cornell, Timothy T, Partap, Soni, Fisher, Paul G, Campen, Cynthia J, Grant, Gerald, Prolo, Laura, Ye, Xiaobu, Sahaf, Bita, Davis, Kara L, Feldman, Steven A, Ramakrishna, Sneha, Mackall, Crystal L

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Potent antitumor efficacy of anti-GD2 CAR T-cells in H3K27M+ diffuse midline gliomas von Mount, Christopher W., Majzner, Robbie G., Sundaresh, Shree, Arnold, Evan P., Kadapakkam, Meena, Haile, Samuel, Labanieh, Louai, Hulleman, Esther, Woo, Pamelyn J., Rietberg, Skyler P., Vogel, Hannes, Monje, Michelle, Mackall, Crystal L.

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DIPG-36. ANTI-GD2 CHIMERIC ANTIGEN RECEPTOR T CELLS AS A POTENT IMMUNOTHERAPY REGIMEN IN XENOGRAFT MODELS OF HISTONE 3 K27M MUTANT DIFFUSE MIDLINE GLIOMA von Mount, Christopher, Majzner, Robbie, Sundaresh, Shree, Arnold, Evan, Kadapakkam, Meena, Haile, Samuel, Labanieh, Louai, Woo, Pamelyn, Rietberg, Skyler, Vogel, Hannes, Monje, Michelle, Mackall, Crystal

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Low CD19 Antigen Density Diminishes Efficacy of CD19 CAR T Cells and Can be Overcome By Rational Redesign of CAR Signaling Domains von Majzner, Robbie G., Rietberg, Skyler P., Labanieh, Louai, Sotillo, Elena, Weber, Evan W., Lynn, Rachel C., Theruvath, Johanna L., Yuan, Constance M., Xu, Peng, Nguyen, Sang M., Shah, Nirali N., Stetler-Stevenson, Maryalice, Fry, Terry J., Lee, Daniel W., Mackall, Crystal L.

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ENHANCEMENT OF POLYPEPTIDES AND CHIMERIC ANTIGEN RECEPTORS VIA HINGE DOMAINS von LABANIEH, Louai, MAJZNER, Robbie, G, RIETBERG, Skyler, P, MACKALL, Crystal, L

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ENHANCEMENT OF POLYPEPTIDES AND CHIMERIC ANTIGEN RECEPTORS VIA HINGE DOMAINS von MACKALL, Crystal, LABANIEH, Louai, RIETBERG, Skyler, MAJZNER, Robbie

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ENHANCEMENT OF POLYPEPTIDES AND CHIMERIC ANTIGEN RECEPTORS VIA HINGE DOMAINS von Labanieh, Louai, Mackall, Crystal L, Rietberg, Skyler P, Majzner, Robbie G

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CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF von MAJZNER, Robbie G, MACKALL, Crystal L, RIETBERG, Skyler P

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ENHANCEMENT OF POLYPEPTIDES AND CHIMERIC ANTIGEN RECEPTORS VIA HINGE DOMAINS von LABANIEH, Louai, MAJZNER, Robbie, G, RIETBERG, Skyler, P, MACKALL, Crystal, L

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Enhancement of polypeptides and chimeric antigen receptors via hinge domains von MAJZNER, Robbie G, LABANIEH, Louai, MACKALL, Crystal L, RIETBERG, Skyler P

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