MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer von Valeri, Nicola, Braconi, Chiara, Gasparini, Pierluigi, Murgia, Claudio, Lampis, Andrea, Paulus-Hock, Viola, Hart, Jonathan R., Ueno, Lynn, Grivennikov, Sergei I., Lovat, Francesca, Paone, Alessio, Cascione, Luciano, Sumani, Khlea M., Veronese, Angelo, Fabbri, Muller, Carasi, Stefania, Alder, Hansjuerg, Lanza, Giovanni, Gafa’, Roberta, Moyer, Mary P., Ridgway, Rachel A., Cordero, Julia, Nuovo, Gerard J., Frankel, Wendy L., Rugge, Massimo, Fassan, Matteo, Groden, Joanna, Vogt, Peter K., Karin, Michael, Sansom, Owen J., Croce, Carlo M.

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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy von Tajan, Mylène, Hennequart, Marc, Cheung, Eric C., Zani, Fabio, Hock, Andreas K., Legrave, Nathalie, Maddocks, Oliver D. K., Ridgway, Rachel A., Athineos, Dimitris, Suárez-Bonnet, Alejandro, Ludwig, Robert L., Novellasdemunt, Laura, Angelis, Nikolaos, Li, Vivian S. W., Vlachogiannis, Georgios, Valeri, Nicola, Mainolfi, Nello, Suri, Vipin, Friedman, Adam, Manfredi, Mark, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis von Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.

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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease von Boulter, Luke, Govaere, Olivier, Bird, Tom G, Radulescu, Sorina, Ramachandran, Prakash, Pellicoro, Antonella, Ridgway, Rachel A, Seo, Sang Soo, Spee, Bart, Van Rooijen, Nico, Sansom, Owen J, Iredale, John P, Lowell, Sally, Roskams, Tania, Forbes, Stuart J

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Crypt stem cells as the cells-of-origin of intestinal cancer von Barker, Nick, Ridgway, Rachel A., van Es, Johan H., van de Wetering, Marc, Begthel, Harry, van den Born, Maaike, Danenberg, Esther, Clarke, Alan R., Sansom, Owen J., Clevers, Hans

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ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation von Myant, Kevin B., Cammareri, Patrizia, McGhee, Ewan J., Ridgway, Rachel A., Huels, David J., Cordero, Julia B., Schwitalla, Sarah, Kalna, Gabriela, Ogg, Erinn-Lee, Athineos, Dimitris, Timpson, Paul, Vidal, Marcos, Murray, Graeme I., Greten, Florian R., Anderson, Kurt I., Sansom, Owen J.

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TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis von Cheung, Eric C., Athineos, Dimitris, Lee, Pearl, Ridgway, Rachel A., Lambie, Wendy, Nixon, Colin, Strathdee, Douglas, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.

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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer von Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.

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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer von Morton, Jennifer P, Timpson, Paul, Karim, Saadia A, Ridgway, Rachel A, Athineos, Dimitris, Doyle, Brendan, Jamieson, Nigel B, Oien, Karin A, Lowy, Andrew M, Brunton, Valerie G, Frame, Margaret C, Evans, T.R. Jeffry, Sansom, Owen J

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Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling von Bird, Thomas G., Lu, Wei-Yu, Boulter, Luke, Gordon-Keylock, Sabrina, Ridgway, Rachel A., Williams, Michael J., Taube, Jessica, Thomas, James A., Wojtacha, Davina, Gambardella, Adriana, Sansom, Owen J., Iredale, John P., Forbes, Stuart J.

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Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression von Bailey, Peter, Ridgway, Rachel A., Cammareri, Patrizia, Treanor-Taylor, Mairi, Bailey, Ulla-Maja, Schoenherr, Christina, Bone, Max, Schreyer, Daniel, Purdie, Karin, Thomson, Jason, Rickaby, William, Jackstadt, Rene, Campbell, Andrew D., Dimonitsas, Emmanouil, Stratigos, Alexander J., Arron, Sarah T., Wang, Jun, Blyth, Karen, Proby, Charlotte M., Harwood, Catherine A., Sansom, Owen J., Leigh, Irene M., Inman, Gareth J.

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ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival von Kanellos, Georgios, Zhou, Jing, Patel, Hitesh, Ridgway, Rachel A., Huels, David, Gurniak, Christine B., Sandilands, Emma, Carragher, Neil O., Sansom, Owen J., Witke, Walter, Brunton, Valerie G., Frame, Margaret C.

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Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma von Cammareri, Patrizia, Rose, Aidan M., Vincent, David F., Wang, Jun, Nagano, Ai, Libertini, Silvana, Ridgway, Rachel A., Athineos, Dimitris, Coates, Philip J., McHugh, Angela, Pourreyron, Celine, Dayal, Jasbani H. S., Larsson, Jonas, Weidlich, Simone, Spender, Lindsay C., Sapkota, Gopal P., Purdie, Karin J., Proby, Charlotte M., Harwood, Catherine A., Leigh, Irene M., Clevers, Hans, Barker, Nick, Karlsson, Stefan, Pritchard, Catrin, Marais, Richard, Chelala, Claude, South, Andrew P., Sansom, Owen J., Inman, Gareth J.

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MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer von Amirkhah, Raheleh, Gilroy, Kathryn, Malla, Sudhir B., Lannagan, Tamsin R. M., Byrne, Ryan M., Fisher, Natalie C., Corry, Shania M., Mohamed, Noha-Ehssan, Naderi-Meshkin, Hojjat, Mills, Megan L., Campbell, Andrew D., Ridgway, Rachel A., Ahmaderaghi, Baharak, Murray, Richard, Llergo, Antoni Berenguer, Sanz-Pamplona, Rebeca, Villanueva, Alberto, Batlle, Eduard, Salazar, Ramon, Lawler, Mark, Sansom, Owen J., Dunne, Philip D.

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KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo von Najumudeen, Arafath K., Fey, Sigrid K., Millett, Laura M., Ford, Catriona A., Gilroy, Kathryn, Gunduz, Nuray, Ridgway, Rachel A., Anderson, Eve, Strathdee, Douglas, Clark, William, Nixon, Colin, Morton, Jennifer P., Campbell, Andrew D., Sansom, Owen J.

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Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue von Quyn, Aaron J., Appleton, Paul L., Carey, Francis A., Steele, Robert J.C., Barker, Nick, Clevers, Hans, Ridgway, Rachel A., Sansom, Owen J., Näthke, Inke S.

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Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling von Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby J., Ridgway, Rachel A., Marsh, Victoria, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan R., Frame, Margaret C., Sansom, Owen J.

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Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop von Walter, Romina J., Sonnentag, Steffen J., Munoz-Sagredo, Leonel, Merkel, Melanie, Richert, Ludovic, Bunert, Felix, Heneka, Yvonne M., Loustau, Thomas, Hodder, Michael, Ridgway, Rachel A., Sansom, Owen J., Mely, Yves, Rothbauer, Ulrich, Schmitt, Mark, Orian-Rousseau, Véronique

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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis von Lindsay, Colin R., Lawn, Samuel, Campbell, Andrew D., Faller, William J., Rambow, Florian, Mort, Richard L., Timpson, Paul, Li, Ang, Cammareri, Patrizia, Ridgway, Rachel A., Morton, Jennifer P., Doyle, Brendan, Hegarty, Shauna, Rafferty, Mairin, Murphy, Ian G., McDermott, Enda W., Sheahan, Kieran, Pedone, Katherine, Finn, Alexander J., Groben, Pamela A., Thomas, Nancy E., Hao, Honglin, Carson, Craig, Norman, Jim C., Machesky, Laura M., Gallagher, William M., Jackson, Ian J., Van Kempen, Leon, Beermann, Friedrich, Der, Channing, Larue, Lionel, Welch, Heidi C., Ozanne, Brad W., Sansom, Owen J.

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Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron von Lindström, Nils O, Lawrence, Melanie L, Burn, Sally F, Johansson, Jeanette A, Bakker, Elvira R M, Ridgway, Rachel A, Chang, C-Hong, Karolak, Michele J, Oxburgh, Leif, Headon, Denis J, Sansom, Owen J, Smits, Ron, Davies, Jamie A, Hohenstein, Peter

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