Correlation of Transcriptomics and FDG-PET SUVmax Indicates Reciprocal Expression of Stemness-Related Transcription Factor and Neuropeptide Signaling Pathways in Glucose Metabolism... von Prexler, Carolin, Knape, Marie Sophie, Erlewein-Schweizer, Janina, Roll, Wolfgang, Specht, Katja, Woertler, Klaus, Weichert, Wilko, von Luettichau, Irene, Rossig, Claudia, Hauer, Julia, Richter, Guenther H S, Weber, Wolfgang, Burdach, Stefan

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Abstract A09: GPR64-specific CAR-transgenic T cells selectively kill Ewing sarcoma in vivo von Schirmer, David, Storz, Isabel, Wisskirchen, Karin, Feederle, Regina, Schmidt, Oxana, Abken, Hinrich, Protzer, Ulrike, Burdach, Stefan, Richter, Guenther H.S.

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Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function von Gassmann, Hendrik, Schneider, Kira, Evdokimova, Valentina, Ruzanov, Peter, Schober, Sebastian J., Xue, Busheng, von Heyking, Kristina, Thiede, Melanie, Richter, Guenther H. S., Pfaffl, Michael W., Noessner, Elfriede, Stein, Lincoln D., Sorensen, Poul H., Burdach, Stefan E. G., Thiel, Uwe

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Abstract B02: Combined targeting of the Ewing sarcoma transcriptional program by blocking epigenetic readers and transcription initiation via EWS-FLI1 von Hensel, Tim, Giorgi, Chiara, Becker-Dettling, Fiona, Calzada-Wack, Julia, Schmidt, Oxana, Wang, Shudong, Schaefer, Beat W., Burdach, Stefan, Richter, Guenther H.S.

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Human HLA-A02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo von Blaeschke, Franziska, Thiel, Uwe, Kirschner, Andreas, Thiede, Melanie, Rubio, Rebeca Alba, Schirmer, David, Kirchner, Thomas, Richter, Günther H S, Mall, Sabine, Klar, Richard, Riddell, Stanley, Busch, Dirk H, Krackhardt, Angela, Grunewald, Thomas G P, Burdach, Stefan

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MHC Class I-Restricted TCR-Transgenic CD4 + T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo von Schober, Sebastian J, Thiede, Melanie, Gassmann, Hendrik, Prexler, Carolin, Xue, Busheng, Schirmer, David, Wohlleber, Dirk, Stein, Stefanie, Grünewald, Thomas G P, Busch, Dirk H, Richter, Guenther H S, Burdach, Stefan E G, Thiel, Uwe

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Abstract C23: Epigenetic regulation of miRNAs and influence on malignancy in Ewing tumors von Richter, Guenther H.S., Plehm, Stephanie, Burdach, Stefan

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The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease von Kovar, Heinrich, Amatruda, James, Brunet, Erika, Burdach, Stefan, Cidre-Aranaz, Florencia, de Alava, Enrique, Dirksen, Uta, van der Ent, Wietske, Grohar, Patrick, Grünewald, Thomas G P, Helman, Lee, Houghton, Peter, Iljin, Kristiina, Korsching, Eberhard, Ladanyi, Marc, Lawlor, Elizabeth, Lessnick, Stephen, Ludwig, Joseph, Meltzer, Paul, Metzler, Markus, Mora, Jaume, Moriggl, Richard, Nakamura, Takuro, Papamarkou, Theodore, Radic Sarikas, Branka, Rédini, Francoise, Richter, Guenther H S, Rossig, Claudia, Schadler, Keri, Schäfer, Beat W, Scotlandi, Katia, Sheffield, Nathan C, Shelat, Anang, Snaar-Jagalska, Ewa, Sorensen, Poul, Stegmaier, Kimberly, Stewart, Elizabeth, Sweet-Cordero, Alejandro, Szuhai, Karoly, Tirado, Oscar M, Tirode, Franck, Toretsky, Jeffrey, Tsafou, Kalliopi, Üren, Aykut, Zinovyev, Andrei, Delattre, Olivier

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Transcriptome based individualized therapy of refractory pediatric cancer in adolescents and young adults von Weidenbusch, Bushra, Richter, Guenther H.S., Dirksen, Uta, Grunewald, Thomas G. P., Lindner, Lars, Teichert von Luettichau, Irene, Mansmann, Ulrich Robert, Burdach, Stefan

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Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: Further evidence toward distinct pat... von Specht, Katja, Sung, Yun-Shao, Zhang, Lei, Richter, Günther H. S., Fletcher, Christopher D., Antonescu, Cristina R.

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EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation von Richter, Günther H.S, Plehm, Stephanie, Fasan, Annette, Rössler, Sabine, Unland, Rebekka, Bennani-Baiti, Idriss M, Hotfilder, Marc, Löwel, Diana, von Luettichau, Irene, Mossbrugger, Ilona, Quintanilla-Martinez, Leticia, Kovar, Heinrich, Staege, Martin S, Müller-Tidow, Carsten, Burdach, Stefan

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Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma von Agelopoulos, Konstantin, Richter, Günther H S, Schmidt, Eva, Dirksen, Uta, von Heyking, Kristina, Moser, Benjamin, Klein, Hans-Ulrich, Kontny, Udo, Dugas, Martin, Poos, Kathrin, Korsching, Eberhard, Buch, Thorsten, Weckesser, Matthias, Schulze, Isabell, Besoke, Regina, Witten, Anika, Stoll, Monika, Köhler, Gabriele, Hartmann, Wolfgang, Wardelmann, Eva, Rossig, Claudia, Baumhoer, Daniel, Jürgens, Heribert, Burdach, Stefan, Berdel, Wolfgang E, Müller-Tidow, Carsten

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Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis von Schmidt, Oxana, Nehls, Nadja, Prexler, Carolin, von Heyking, Kristina, Groll, Tanja, Pardon, Katharina, Garcia, Heathcliff D, Hensel, Tim, Gürgen, Dennis, Henssen, Anton G, Eggert, Angelika, Steiger, Katja, Burdach, Stefan, Richter, Günther H S

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DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma von HAUER, Kristina, CALZADA-WACK, Julia, RICHTER, Günther H. S, STEIGER, Katja, GRUNEWALD, Thomas G. P, BAUMHOER, Daniel, PLEHM, Stephanie, BUCH, Thorsten, DA COSTA, Olivia Prazeres, ESPOSITO, Irene, BURDACH, Stefan

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Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma von Hensel, Tim, Giorgi, Chiara, Schmidt, Oxana, Calzada-Wack, Julia, Neff, Frauke, Buch, Thorsten, Niggli, Felix K, Schäfer, Beat W, Burdach, Stefan, Richter, Günther H S

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MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress von Sipol, Alexandra, Hameister, Erik, Xue, Busheng, Hofstetter, Julia, Barenboim, Maxim, Öllinger, Rupert, Jain, Gaurav, Prexler, Carolin, Rubio, Rebeca Alba, Baldauf, Michaela C., Franchina, Davide G., Petry, Andreas, Schmäh, Juliane, Thiel, Uwe, Görlach, Agnes, Cario, Gunnar, Brenner, Dirk, Richter, Günther H.S., Grünewald, Thomas G.P., Rad, Roland, Wolf, Elmar, Ruland, Jürgen, Sorensen, Poul H., Burdach, Stefan E.G.

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The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma von Heyking, Kristina, Calzada‐Wack, Julia, Göllner, Stefanie, Neff, Frauke, Schmidt, Oxana, Hensel, Tim, Schirmer, David, Fasan, Annette, Esposito, Irene, Müller‐Tidow, Carsten, Sorensen, Poul H., Burdach, Stefan, Richter, Günther H. S.

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Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma von Richter, Günther H S, Hensel, Tim, Schmidt, Oxana, Saratov, Vadim, von Heyking, Kristina, Becker-Dettling, Fiona, Prexler, Carolin, Yen, Hsi-Yu, Steiger, Katja, Fulda, Simone, Dirksen, Uta, Weichert, Wilko, Wang, Shudong, Burdach, Stefan, Schäfer, Beat W

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Matrix mineralization controls gene expression in osteoblastic cells von Wischmann, Johannes, Lenze, Florian, Thiel, Antonia, Bookbinder, Sakina, Querido, William, Schmidt, Oxana, Burgkart, Rainer, von Eisenhart-Rothe, Rüdiger, Richter, Günther H.S., Pleshko, Nancy, Mayer-Kuckuk, Philipp

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The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma von von Heyking, Kristina, Roth, Laura, Ertl, Miriam, Schmidt, Oxana, Calzada-Wack, Julia, Neff, Frauke, Lawlor, Elizabeth R, Burdach, Stefan, Richter, Guenther Hs

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