G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1 von Richter, Günther HS, Fasan, Annette, Hauer, Kristina, Grunewald, Thomas GP, Berns, Colette, Rössler, Sabine, Naumann, Ivonne, Staege, Martin S., Fulda, Simone, Esposito, Irene, Burdach, Stefan

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Abstract A27: BET bromodomain proteins in Ewing sarcoma regulate a specific transcriptional program, tumorigenicity and apoptosis by interacting with EWS-FLI1 and the positive tran... von Hensel, Tim, Giorgi, Chiara, Becker-Dettling, Fiona, Calzada-Wack, Julia, Neff, Frauke, Schmidt, Oxana, Wang, Shudong, Schäfer, Beat W., Burdach, Stefan, Richter, Günther HS

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Abstract 3864: Combined targeting of the EWS/ETS transcriptional program by blocking epigenetic readers and transcription initiation in Ewing sarcoma von Hensel, Tim, Giorgi, Chiara, Becker-Dettling, Fiona, Calzada-Wack, Julia, Neff, Frauke, Schmidt, Oxana, Wang, Shudong, Schäfer, Beat W., Burdach, Stefan, Richter, Günther HS

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Abstract 2468: Combined targeting of the EWS/ETS transcriptional program by BET bromodomain and PI3K pathway inhibition blocks tumorigenicity and increases apoptosis in Ewing sarco... von Hensel, Tim, Giorgi, Chiara, Becker-Dettling, Fiona, Calzada-Wack, Julia, Neff, Frauke, Buch, Thorsten, Schmidt, Oxana, Schäfer, Beat W., Burdach, Stefan, Richter, Günther HS

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Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas von Specht, Katja, Zhang, Lei, Sung, Yun-Shao, Nucci, Marisa, Dry, Sarah, Vaiyapuri, Sumathi, Richter, Gunther H.S, Fletcher, Christopher D.M, Antonescu, Cristina R

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ITOC2 – 028. Transgenic antigen-specific, allogeneic HLA-A∗ 0201-restricted cytotoxic T cells recogniae tumour-associated target antigen STEAP1 with high specificity von David, Schirmer, Dirk, Busch H, Wolfgang, Uckert, Angela, Krackhardt, Richard, Klar, Stefan, Burdach, Günther, Richter HS

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Abstract B63: Therapeutic potential of GPR64 specific CAR T cells in pediatric sarcomas von Storz, Isabel, Schirmer, David, Wisskirchen, Karin, Feederle, Regina, Schmidt, Oxana, Abken, Hinrich, Protzer, Ulrike, Burdach, Stefan, Richter, Günther HS

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Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: Further evidence toward distinct pat... von Specht, Katja, Sung, Yun-Shao, Zhang, Lei, Richter, Günther H. S., Fletcher, Christopher D., Antonescu, Cristina R.

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EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation von Richter, Günther H.S, Plehm, Stephanie, Fasan, Annette, Rössler, Sabine, Unland, Rebekka, Bennani-Baiti, Idriss M, Hotfilder, Marc, Löwel, Diana, von Luettichau, Irene, Mossbrugger, Ilona, Quintanilla-Martinez, Leticia, Kovar, Heinrich, Staege, Martin S, Müller-Tidow, Carsten, Burdach, Stefan

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Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma von Agelopoulos, Konstantin, Richter, Günther H S, Schmidt, Eva, Dirksen, Uta, von Heyking, Kristina, Moser, Benjamin, Klein, Hans-Ulrich, Kontny, Udo, Dugas, Martin, Poos, Kathrin, Korsching, Eberhard, Buch, Thorsten, Weckesser, Matthias, Schulze, Isabell, Besoke, Regina, Witten, Anika, Stoll, Monika, Köhler, Gabriele, Hartmann, Wolfgang, Wardelmann, Eva, Rossig, Claudia, Baumhoer, Daniel, Jürgens, Heribert, Burdach, Stefan, Berdel, Wolfgang E, Müller-Tidow, Carsten

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Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system von Unland, Rebekka, Kerl, Kornelius, Schlosser, Sabrina, Farwick, Nicole, Plagemann, Tanja, Lechtape, Birigit, Clifford, Steven C., Kreth, Jonas H., Gerss, Joachim, Mühlisch, Jörg, Richter, Günther H. S., Hasselblatt, Martin, Frühwald, Michael C.

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Matrix Metalloproteinase-12 Expression Correlates with Local Recurrence and Metastatic Disease in Non–Small Cell Lung Cancer Patients von HOFMANN, Hans-Stefan, HANSEN, Gesine, RICHTER, Günther, TAEGE, Christiane, SIMM, Andreas, SILBER, Rolf-Edgar, BURDACH, Stefan

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The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma von von Heyking, Kristina, Roth, Laura, Ertl, Miriam, Schmidt, Oxana, Calzada-Wack, Julia, Neff, Frauke, Lawlor, Elizabeth R, Burdach, Stefan, Richter, Guenther Hs

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