Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 von Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Scott, Margaret Porter, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas von Sneeringer, Christopher J., Scott, Margaret Porter, Kuntz, Kevin W., Knutson, Sarah K., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Wells, James A.

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia von Daigle, Scott R., Olhava, Edward J., Therkelsen, Carly A., Basavapathruni, Aravind, Jin, Lei, Boriack-Sjodin, P. Ann, Allain, Christina J., Klaus, Christine R., Raimondi, Alejandra, Scott, Margaret Porter, Waters, Nigel J., Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M.

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells von Knutson, Sarah K, Wigle, Tim J, Warholic, Natalie M, Sneeringer, Christopher J, Allain, Christina J, Klaus, Christine R, Sacks, Joelle D, Raimondi, Alejandra, Majer, Christina R, Song, Jeffrey, Scott, Margaret Porter, Jin, Lei, Smith, Jesse J, Olhava, Edward J, Chesworth, Richard, Moyer, Mikel P, Richon, Victoria M, Copeland, Robert A, Keilhack, Heike, Pollock, Roy M, Kuntz, Kevin W

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The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat von Kuntz, Kevin W, Campbell, John E, Keilhack, Heike, Pollock, Roy M, Knutson, Sarah K, Porter-Scott, Margaret, Richon, Victoria M, Sneeringer, Chris J, Wigle, Tim J, Allain, Christina J, Majer, Christina R, Moyer, Mikel P, Copeland, Robert A, Chesworth, Richard

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Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor von Daigle, Scott R., Olhava, Edward J., Therkelsen, Carly A., Majer, Christina R., Sneeringer, Christopher J., Song, Jeffrey, Johnston, L. Danielle, Scott, Margaret Porter, Smith, Jesse J., Xiao, Yonghong, Jin, Lei, Kuntz, Kevin W., Chesworth, Richard, Moyer, Mikel P., Bernt, Kathrin M., Tseng, Jen-Chieh, Kung, Andrew L., Armstrong, Scott A., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M.

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Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l von Deshpande, Aniruddha J., Chen, Liying, Fazio, Maurizio, Sinha, Amit U., Bernt, Kathrin M., Banka, Deepti, Dias, Stuart, Chang, Jenny, Olhava, Edward J., Daigle, Scott R., Richon, Victoria M., Pollock, Roy M., Armstrong, Scott A.

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Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study von GALANIS, Evanthia, JAECKLE, Kurt A, RICHON, Victoria M, SCHEITHAUER, Bernd, GIANNINI, Caterina, FLYNN, Patrick J, MOORE, Dennis F, ZWIEBEL, James, BUCKNER, Jan C, MAURER, Matthew J, REID, Joel M, AMES, Matthew M, HARDWICK, James S, REILLY, John F, LOBODA, Andrey, NEBOZHYN, Michael, FANTIN, Valeria R

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Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer von KELLY, William Kevin, O'CONNOR, Owen A, RICHARDSON, Stacy, CHU, Elaina, OLGAC, Semra, MARKS, Paul A, SCHER, Howard, RICHON, Victoria M, KRUG, Lee M, CHIAO, Judy H, HEANEY, Mark, CURLEY, Tracy, MACGREGORE-CORTELLI, Barbara, TONG, William, SECRIST, J. Paul, SCHWARTZ, Lawrence

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Mechanisms of Resistance to Histone Deacetylase Inhibitors and Their Therapeutic Implications von FANTIN, Valeria R, RICHON, Victoria M

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A687V EZH2 is a gain-of-function mutation found in lymphoma patients von Majer, Christina R., Jin, Lei, Scott, Margaret Porter, Knutson, Sarah K., Kuntz, Kevin W., Keilhack, Heike, Smith, Jesse J., Moyer, Mikel P., Richon, Victoria M., Copeland, Robert A., Wigle, Tim J.

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Chemogenetic Analysis of Human Protein Methyltransferases von Richon, Victoria M., Johnston, Danielle, Sneeringer, Christopher J., Jin, Lei, Majer, Christina R., Elliston, Keith, Jerva, L. Fred, Scott, Margaret Porter, Copeland, Robert A.

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Identification and Functional Significance of Genes Regulated by Structurally Different Histone Deacetylase Inhibitors von Peart, Melissa J., Smyth, Gordon K., van Laar, Ryan K., Bowtell, David D., Richon, Victoria M., Marks, Paul A., Holloway, Andrew J., Johnstone, Ricky W.

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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states von Wigle, Tim J., Knutson, Sarah K., Jin, Lei, Kuntz, Kevin W., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Scott, Margaret Porter

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Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Ameliorates Motor Deficits in a Mouse Model of Huntington's Disease von Hockly, Emma, Richon, Victoria M., Woodman, Benjamin, Smith, Donna L., Zhou, Xianbo, Rosa, Eddie, Sathasivam, Kirupa, Ghazi-Noori, Shabnam, Mahal, Amarbirpal, Philip A. S. Lowden, Steffan, Joan S., Marsh, J. Lawrence, Thompson, Leslie M., Lewis, Cathryn M., Marks, Paul A., Bates, Gillian P.

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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L von Bernt, Kathrin M., Zhu, Nan, Sinha, Amit U., Vempati, Sridhar, Faber, Joerg, Krivtsov, Andrei V., Feng, Zhaohui, Punt, Natalie, Daigle, Amanda, Bullinger, Lars, Pollock, Roy M., Richon, Victoria M., Kung, Andrew L., Armstrong, Scott A.

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The Histone Deacetylase Inhibitor SAHA Arrests Cancer Cell Growth, Up-Regulates Thioredoxin-Binding Protein-2, and Down-Regulates Thioredoxin von Butler, Lisa M., Zhou, Xianbo, Xu, Wei-Sheng, Scher, Howard I., Rifkind, Richard A., Marks, Paul A., Richon, Victoria M.

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Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of γ-H2AX foci von Munshi, Anupama, Tanaka, Toshimitsu, Hobbs, Marvette L, Tucker, Susan L, Richon, Victoria M, Meyn, Raymond E

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Vorinostat in solid and hematologic malignancies von Siegel, David, Hussein, Mohamad, Belani, Chandra, Robert, Francisco, Galanis, Evanthia, Richon, Victoria M, Garcia-Vargas, José, Sanz-Rodriguez, Cesar, Rizvi, Syed

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors von Finnin, Michael S., Donigian, Jill R., Cohen, Alona, Richon, Victoria M., Rifkind, Richard A., Marks, Paul A., Breslow, Ronald, Pavletich, Nikola P.

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