Glucose-6-phosphatase Catalytic Subunit Gene Family von Hutton, John C., O'Brien, Richard M.

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Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model von Hawes, Emily M, Claxton, Derek P, Oeser, James K, O'Brien, Richard M

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Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion von Pound, Lynley D, Sarkar, Suparna A, Benninger, Richard K P, Wang, Yingda, Suwanichkul, Adisak, Shadoan, Melanie K, Printz, Richard L, Oeser, James K, Lee, Catherine E, Piston, David W, McGuinness, Owen P, Hutton, John C, Powell, David R, O'Brien, Richard M

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Chronic Glucocorticoid Exposure Induced an S1PR2-RORγ Axis to Enhance Hepatic Gluconeogenesis in Male Mice von Lee, Rebecca A, Chang, Maggie, Tsay, Ariel, Lee, Yeong Rim, Li, Danielle, Yiv, Nicholas, Tian, Sharon, Zhao, Michelle, O'Brien, Richard M, Wang, Jen-Chywan

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G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity von Hawes, Emily M, Boortz, Kayla A, Oeser, James K, O'Rourke, Margaret L, O'Brien, Richard M

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Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose von Overway, Emily M., Bosma, Karin J., Claxton, Derek P., Oeser, James K., Singh, Kritika, Breidenbach, Lindsay B., Mchaourab, Hassane S., Davis, Lea K., O'Brien, Richard M.

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Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose von O’Brien, Richard M.

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An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets von Keller, Mark P, Hawes, Emily M, Schueler, Kathryn L, Stapleton, Donnie S, Mitok, Kelly A, Simonett, Shane P, Oeser, James K, Sampson, Leesa L, Attie, Alan D, Magnuson, Mark A, O'Brien, Richard M

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Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids o... von Boortz, Kayla A, Syring, Kristen E, Pound, Lynley D, Wang, Yingda, Oeser, James K, O'Brien, Richard M

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Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species von Bosma, Karin J., Syring, Kristen E., Oeser, James K., Lee, Jason D., Benninger, Richard K. P., Pamenter, Matthew E., O’Brien, Richard M.

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The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content von Syring, Kristen E., Bosma, Karin J., Oeser, James K., Shiota, Masakazu, O’Brien, Richard M.

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Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter von Singh, Puja, Han, Eun Hee, Endrizzi, James A., O'Brien, Richard M., Chi, Young-In

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G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance von Boortz, Kayla A, Syring, Kristen E, Lee, Rebecca A, Dai, Chunhua, Oeser, James K, McGuinness, Owen P, Wang, Jen-Chywan, O'Brien, Richard M

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Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion von Edgerton, Dale S, Kraft, Guillaume, Smith, Marta, Farmer, Ben, Williams, Phillip E, Coate, Katie C, Printz, Richard L, O'Brien, Richard M, Cherrington, Alan D

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Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model von Sinclair, Matt, Stein, Richard A, Sheehan, Jonathan H, Hawes, Emily M, O'Brien, Richard M, Tajkhorshid, Emad, Claxton, Derek P

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Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets von Wall, Martha L, Pound, Lynley D, Trenary, Irina, O'Brien, Richard M, Young, Jamey D

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Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration von Kim, Yong Kyung, Walters, Jay A., Moss, Nicole D., Wells, Kristen L., Sheridan, Ryan, Miranda, Jose G., Benninger, Richard K.P., Pyle, Laura L., O'Brien, Richard M., Sussel, Lori, Davidson, Howard W.

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G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting von Bosma, Karin J., Rahim, Mohsin, Oeser, James K., McGuinness, Owen P., Young, Jamey D., O'Brien, Richard M.

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Zinc transporter 8 (ZnT8) and β cell function von Davidson, Howard W, Wenzlau, Janet M, O’Brien, Richard M

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The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer von Pound, Lynley D, Hang, Yan, Sarkar, Suparna A, Wang, Yingda, Milam, Laurel A, Oeser, James K, Printz, Richard L, Lee, Catherine E, Stein, Roland, Hutton, John C, O'Brien, Richard M

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