Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies von Foster, Evangeline M, Dangla-Valls, Adrià, Lovestone, Simon, Ribe, Elena M, Buckley, Noel J

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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice von Mancuso, Renzo, Fryatt, Gemma, Cleal, Madeleine, Obst, Juliane, Pipi, Elena, Monzón-Sandoval, Jimena, Ribe, Elena, Winchester, Laura, Webber, Caleb, Nevado, Alejo, Jacobs, Tom, Austin, Nigel, Theunis, Clara, Grauwen, Karolien, Daniela Ruiz, Eva, Mudher, Amrit, Vicente-Rodriguez, Marta, Parker, Christine A, Simmons, Camilla, Cash, Diana, Richardson, Jill, Jones, Declan N C, Lovestone, Simon, Gómez-Nicola, Diego, Perry, V Hugh

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Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory von Puzzo, Daniela, Privitera, Lucia, Fa', Mauro, Staniszewski, Agnieszka, Hashimoto, Gakuji, Aziz, Fahad, Sakurai, Mikako, Ribe, Elena M., Troy, Carol M., Mercken, Marc, Jung, Sonia S., Palmeri, Agostino, Arancio, Ottavio

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Glycosylated clusterin species facilitate Aβ toxicity in human neurons von Foster, Evangeline M., Fernandes, Marco, Dangla-Valls, Adria, Hublitz, Philip, Pangalos, Menelaos, Lovestone, Simon, Ribe, Elena M., Buckley, Noel J.

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NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology von Rojo, Ana I., Pajares, Marta, Rada, Patricia, Nuñez, Angel, Nevado-Holgado, Alejo J., Killik, Richard, Van Leuven, Fred, Ribe, Elena, Lovestone, Simon, Yamamoto, Masayuki, Cuadrado, Antonio

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Mechanisms of neuronal death in disease: defining the models and the players von Ribe, Elena M, Serrano-Saiz, Esther, Akpan, Nsikan, Troy, Carol M

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Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice von Pozueta, Julio, Lefort, Roger, Ribe, Elena M., Troy, Carol M., Arancio, Ottavio, Shelanski, Michael

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Comorbidity between Alzheimer's disease and major depression: a behavioural and transcriptomic characterization study in mice von Martin-Sanchez, Ana, Pinero, Janet, Nonell, Lara, Arnal, Magdalena, Ribe, Elena M., Nevado-Holgado, Alejo, Lovestone, Simon, Sanz, Ferran, Furlong, Laura I., Valverde, Olga

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The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice von To, Alvina W M, Ribe, Elena M, Chuang, Tsu Tshen, Schroeder, Joern E, Lovestone, Simon

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Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer's Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil von Killick, Richard, Elliott, Christina, Ribe, Elena, Broadstock, Martin, Ballard, Clive, Aarsland, Dag, Williams, Gareth

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Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons von Robbins, Jacqueline P, Perfect, Leo, Ribe, Elena M, Maresca, Marcello, Dangla-Valls, Adrià, Foster, Evangeline M, Killick, Richard, Nowosiad, Paulina, Reid, Matthew J, Polit, Lucia Dutan, Nevado, Alejo J, Ebner, Daniel, Bohlooly-Y, Mohammad, Buckley, Noel, Pangalos, Menelas N, Price, Jack, Lovestone, Simon

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Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death von Jean, Ying Y, Ribe, Elena M, Pero, Maria Elena, Moskalenko, Marina, Iqbal, Zarah, Marks, Lianna J, Greene, Lloyd A, Troy, Carol M

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Neuronal caspase 2 activity and function requires RAIDD, but not PIDD von Ribe, Elena M, Jean, Ying Y, Goldstein, Rebecca L, Manzl, Claudia, Stefanis, Leonidas, Villunger, Andreas, Troy, Carol M

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Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology von Shi, Liu, Freund-Levi, Yvonne, Lovestone, Simon

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Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer's Disease Therapeutic Development von Nevado-Holgado, Alejo J, Ribe, Elena, Thei, Laura, Furlong, Laura, Mayer, Miguel-Angel, Quan, Jie, Richardson, Jill C, Cavanagh, Jonathan, Consortium, Nima, Lovestone, Simon

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Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability von Ng, Bryan, Rowland, Helen A, Wei, Tina, Arunasalam, Kanisa, Hayes, Emma Mee, Koychev, Ivan, Hedegaard, Anne, Ribe, Elena M, Chan, Dennis, Chessell, Tharani, Ffytche, Dominic, Gunn, Roger N, Kocagoncu, Ece, Lawson, Jennifer, Malhotra, Paresh A, Ridha, Basil H, Rowe, James B, Thomas, Alan J, Zamboni, Giovanna, Buckley, Noel J, Cader, Zameel M, Lovestone, Simon, Wade-Martins, Richard

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Caspase-2: vestigial remnant or master regulator? von Troy, Carol M, Ribe, Elena M

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Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice von Ribé, Elena M., Pérez, Mar, Puig, Berta, Gich, Ignasi, Lim, Filip, Cuadrado, Mar, Sesma, Teresa, Catena, Silvia, Sánchez, Belén, Nieto, María, Gómez-Ramos, Pilar, Morán, M.Asunción, Cabodevilla, Felipe, Samaranch, Lluis, Ortiz, Lourdes, Pérez, Alberto, Ferrer, Isidro, Avila, Jesús, Gómez-Isla, Teresa

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The effects of pioglitazone on tau phosphorylation in apoE models of insulin resistance von To, Alvina W.M, Ribe, Elena M, Schroeder, Joern E, Lovestone, Simon

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Inflammatory biomarkers in Alzheimer's disease plasma von Morgan, Angharad R., Touchard, Samuel, Barkhof, Frederik, Bertram, Lars, Bos, Isabelle, Dobricic, Valerija, Frisoni, Giovanni, Frölich, Lutz, Gabel, Silvey, Kettunen, Petronella, Lleó, Alberto, Martinez-Lage, Pablo, Mecocci, Patrizia, Meersmans, Karen, Molinuevo, José Luis, Peyratout, Gwendoline, Popp, Julius, Richardson, Jill, Scheltens, Philip, Soininen, Hikka, Tsolaki, Magda, Vos, Stephanie, Wahlund, Lars-Olof, Wallin, Anders, Westwood, Sarah, Lovestone, Simon, Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Crofts, Anna L., Foster, Andrew C., Kitzbichler, Manfred G., Lynall, Mary-Ellen, Maurice, Christina, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Cavanagh, Jonathan, Deith, Catherine, McColl, Alison, Scouller, Paul, Sutherland, Murray, Khan, Shahid, Murphy, Phil, Patel, Jai, de Boer, Peter, Drevets, Wayne C., Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Cash, Diana, Mondelli, Valeria, Nikkheslat, Naghmeh, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Van Loo, Victoria, Vicente-Rodriguez, Marta, Worrell, Courtney, Plath, Niels, Egebjerg, Jan, Gastambide, Francois, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Jones, Helen, Lovestone, Simon, Mada, Francisca, Oladejo, Akintayo, Ribe, Elena, Smith, Katy, Vyas, Anviti, Sporn, Jonathan, Fryatt, Gemma, Gomez-Nicola, Diego, Mancuso, Renzo, Reynolds, Richard, Cercignani, Mara, Clarke, Charlotte L., Hoskins, Elizabeth, Murray, Rosemary, Wlazly, Dominika, Mount, Howard

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