Improving CRISPR-Cas nuclease specificity using truncated guide RNAs von Fu, Yanfang, Sander, Jeffry D, Reyon, Deepak, Cascio, Vincent M, Joung, J Keith

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells von Fu, Yanfang, Foden, Jennifer A, Khayter, Cyd, Maeder, Morgan L, Reyon, Deepak, Joung, J Keith, Sander, Jeffry D

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Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing von Tsai, Shengdar Q, Wyvekens, Nicolas, Khayter, Cyd, Foden, Jennifer A, Thapar, Vishal, Reyon, Deepak, Goodwin, Mathew J, Aryee, Martin J, Joung, J Keith

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Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10 von Maeder, Morgan L., Stefanidakis, Michael, Wilson, Christopher J., Baral, Reshica, Barrera, Luis Alberto, Bounoutas, George S., Bumcrot, David, Chao, Hoson, Ciulla, Dawn M., DaSilva, Jennifer A., Dass, Abhishek, Dhanapal, Vidya, Fennell, Tim J., Friedland, Ari E., Giannoukos, Georgia, Gloskowski, Sebastian W., Glucksmann, Alexandra, Gotta, Gregory M., Jayaram, Hariharan, Haskett, Scott J., Hopkins, Bei, Horng, Joy E., Joshi, Shivangi, Marco, Eugenio, Mepani, Rina, Reyon, Deepak, Ta, Terence, Tabbaa, Diana G., Samuelsson, Steven J., Shen, Shen, Skor, Maxwell N., Stetkiewicz, Pam, Wang, Tongyao, Yudkoff, Clifford, Myer, Vic E., Albright, Charles F., Jiang, Haiyan

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FLASH assembly of TALENs for high-throughput genome editing von Reyon, Deepak, Tsai, Shengdar Q, Khayter, Cyd, Foden, Jennifer A, Sander, Jeffry D, Joung, J Keith

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Locus-specific editing of histone modifications at endogenous enhancers von Mendenhall, Eric M, Williamson, Kaylyn E, Reyon, Deepak, Zou, James Y, Ram, Oren, Joung, J Keith, Bernstein, Bradley E

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Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells von Liao, Jing, Karnik, Rahul, Gu, Hongcang, Ziller, Michael J, Clement, Kendell, Tsankov, Alexander M, Akopian, Veronika, Gifford, Casey A, Donaghey, Julie, Galonska, Christina, Pop, Ramona, Reyon, Deepak, Tsai, Shengdar Q, Mallard, William, Joung, J Keith, Rinn, John L, Gnirke, Andreas, Meissner, Alexander

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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins von Maeder, Morgan L, Angstman, James F, Richardson, Marcy E, Linder, Samantha J, Cascio, Vincent M, Tsai, Shengdar Q, Ho, Quan H, Sander, Jeffry D, Reyon, Deepak, Bernstein, Bradley E, Costello, Joseph F, Wilkinson, Miles F, Joung, J Keith

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Heritable and precise zebrafish genome editing using a CRISPR-Cas system von Hwang, Woong Y, Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L, Kaini, Prakriti, Sander, Jeffry D, Joung, J Keith, Peterson, Randall T, Yeh, Jing-Ruey Joanna

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Robust, synergistic regulation of human gene expression using TALE activators von Maeder, Morgan L, Linder, Samantha J, Reyon, Deepak, Angstman, James F, Fu, Yanfang, Sander, Jeffry D, Joung, J Keith

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Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs von Cade, Lindsay, Reyon, Deepak, Hwang, Woong Y, Tsai, Shengdar Q, Patel, Samir, Khayter, Cyd, Joung, J Keith, Sander, Jeffry D, Peterson, Randall T, Yeh, Jing-Ruey Joanna

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High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases von Zhang, Feng, Maeder, Morgan L., Unger-Wallace, Erica, Hoshaw, Justin P., Reyon, Deepak, Christian, Michelle, Li, Xiaohong, Pierick, Christopher J., Dobbs, Drena, Peterson, Thomas, Joung, J. Keith, Voytas, Daniel F., Ecker, Joseph R.

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Nodal patterning without Lefty inhibitory feedback is functional but fragile von Rogers, Katherine W, Lord, Nathan D, Gagnon, James A, Pauli, Andrea, Zimmerman, Steven, Aksel, Deniz C, Reyon, Deepak, Tsai, Shengdar Q, Joung, J Keith, Schier, Alexander F

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Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis von Johnson, Bryce G, Dang, Lan T, Marsh, Graham, Roach, Allie M, Levine, Zebulon G, Monti, Anthony, Reyon, Deepak, Feigenbaum, Lionel, Duffield, Jeremy S

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Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells von Dastidar, Sumitava, Ardui, Simon, Singh, Kshitiz, Majumdar, Debanjana, Nair, Nisha, Fu, Yanfang, Reyon, Deepak, Samara, Ermira, Gerli, Mattia F M, Klein, Arnaud F, De Schrijver, Wito, Tipanee, Jaitip, Seneca, Sara, Tulalamba, Warut, Wang, Hui, Chai, Yoke Chin, In't Veld, Peter, Furling, Denis, Tedesco, Francesco Saverio, Vermeesch, Joris R, Joung, J Keith, Chuah, Marinee K, VandenDriessche, Thierry

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Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA) von Joung, J Keith, Sander, Jeffry D, Dahlborg, Elizabeth J, Goodwin, Mathew J, Cade, Lindsay, Zhang, Feng, Cifuentes, Daniel, Curtin, Shaun J, Blackburn, Jessica S, Thibodeau-Beganny, Stacey, Qi, Yiping, Pierick, Christopher J, Hoffman, Ellen, Maeder, Morgan L, Khayter, Cyd, Reyon, Deepak, Dobbs, Drena, Langenau, David M, Stupar, Robert M, Giraldez, Antonio J, Voytas, Daniel F, Peterson, Randall T, Yeh, Jing-Ruey J

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Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish von Grzegorski, Steven J., Hu, Zhilian, Liu, Yang, Yu, Xinge, Ferguson, Allison C., Madarati, Hasam, Friedmann, Alexander P., Reyon, Deepak, Kim, Paul Y., Kretz, Colin A., Joung, J. Keith, Shavit, Jordan A.

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Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice von Sproule, Thomas J, Wilpan, Robert Y, Low, Benjamin E, Silva, Kathleen A, Reyon, Deepak, Joung, J Keith, Wiles, Michael V, Roopenian, Derry C, Sundberg, John P

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Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state von Weichert-Leahey, Nina, Shi, Hui, Tao, Ting, Oldridge, Derek A, Durbin, Adam D, Abraham, Brian J, Zimmerman, Mark W, Zhu, Shizhen, Wood, Andrew C, Reyon, Deepak, Joung, J Keith, Young, Richard A, Diskin, Sharon J, Maris, John M, Look, A Thomas

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Improved somatic mutagenesis in zebrafish using transcription activator-like effector nucleases (TALENs) von Moore, Finola E, Reyon, Deepak, Sander, Jeffry D, Martinez, Sarah A, Blackburn, Jessica S, Khayter, Cyd, Ramirez, Cherie L, Joung, J Keith, Langenau, David M

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