Type I interferon: potential therapeutic target for psoriasis? von Yao, Yihong, Richman, Laura, Morehouse, Chris, de los Reyes, Melissa, Higgs, Brandon W, Boutrin, Anmarie, White, Barbara, Coyle, Anthony, Krueger, James, Kiener, Peter A, Jallal, Bahija

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275 Translational endpoints associated with STK11 mutations in patients with non-squamous NSCLC von Wu, Song, Standifer, Nathan, Reyes, Melissa de los, Oberst, Micheal, Raja, Rajv, Barrett, Carl, Ascierto, Maria

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Circulating Immune Cell and Outcome Analysis from the Phase II Study of PD-L1 Blockade with Durvalumab for Newly Diagnosed and Recurrent Glioblastoma von Nayak, Lakshmi, Standifer, Nathan, Dietrich, Jorg, Clarke, Jennifer L, Dunn, Gavin P, Lim, Michael, Cloughesy, Timothy, Gan, Hui K, Flagg, Elizabeth, George, Elizabeth, Gaffey, Sarah, Hayden, Julia, Holcroft, Christina, Wen, Patrick Y, Macri, Mary, Park, Andrew J, Ricciardi, Toni, Ryan, Aileen, Schwarzenberger, Paul, Venhaus, Ralph, Reyes, Melissa de Los, Durham, Nicholas M, Creasy, Todd, Huang, Raymond Y, Kaley, Thomas, Reardon, David A

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266 Tumour mutation burden (TMB) and efficacy outcomes in the phase III DANUBE study of advanced urothelial carcinoma (UC) von Wildsmith, Sophie, Walker, Jill, L’Hernault, Anne, Li, Weimin, Bye, Hannah, He, Philip, Xiao, Feng, Zhang, Qu, Stewart, Ross, Reyes, Melissa de los, Raja, Rajiv, Levin, Wendy, Gupta, Ashok, Powles, Thomas, Bellmunt, Joaquim, Galsky, Matthew, Drakaki, Alexandra, Heijden, Michiel van der

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Evaluation of ultra-low input RNA sequencing for the study of human T cell transcriptome von Wang, Jingya, Rieder, Sadiye Amcaoglu, Wu, Jincheng, Hayes, Susana, Halpin, Rebecca A., de los Reyes, Melissa, Shrestha, Yashaswi, Kolbeck, Roland, Raja, Rajiv

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Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase von Burnside, Kellie, Lembo, Annalisa, de Los Reyes, Melissa, Iliuk, Anton, Binhtran, Nguyen-Thao, Connelly, James E, Lin, Wan-Jung, Schmidt, Byron Z, Richardson, Anthony R, Fang, Ferric C, Tao, Weiguo Andy, Rajagopal, Lakshmi

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Regulation of CovR expression in Group B Streptococcus impacts blood–brain barrier penetration von Lembo, Annalisa, Gurney, Michael A., Burnside, Kellie, Banerjee, Anirban, De Los Reyes, Melissa, Connelly, James E., Lin, Wan‐Jung, Jewell, Kelsea A., Vo, Anthony, Renken, Christian W., Doran, Kelly S., Rajagopal, Lakshmi

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Feno differentiates epithelial gene expression clusters: Exploratory analysis from the MESOS randomized controlled trial von Diver, Sarah, Sridhar, Sriram, Khalfaoui, Latifa C., Russell, Richard J., Emson, Claire, Griffiths, Janet M., de los Reyes, Melissa, Yin, Da, Colice, Gene, Brightling, Christopher E.

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FRI-358-Differentiation of glucagon and glucagon-like peptide-1 effects on hepatocytes von Wang, Xiaozhen, Conway, James, Beaton, Michelle, Reyes, Melissa De Los, Raja, Rajiv

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Tumor Mutational Burden as a Predictor of Survival with Durvalumab and/or Tremelimumab Treatment in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma von Wildsmith, Sophie, Li, Weimin, Wu, Song, Stewart, Ross, Morsli, Nassim, Raja, Rajiv, Zhang, Qu, Ye, Jiabu, He, Philip, Shetty, Jagdish, Yovine, Alejandro, Holoweckyj, Nicholas, Real, Katia, Walker, Jill, Wrona, Magdalena, de Los Reyes, Melissa, Barker, Craig, Whiteley, Jessica, Haddad, Robert, Licitra, Lisa, Ferris, Robert, Fayette, Jérôme, Zandberg, Dan P, Siu, Lillian L, Mesía, Ricard

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Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdo... von Pore, Nabendu, Wu, Song, Standifer, Nathan, Jure-Kunkel, Maria, de los Reyes, Melissa, Shrestha, Yashaswi, Halpin, Rebecca, Rothstein, Raymond, Mulgrew, Kathy, Blackmore, Stephen, Martin, Philip, Meekin, John, Griffin, Matthew, Bisha, Ina, Proia, Theresa A., Miragaia, Ricardo J., Herbst, Ronald, Gupta, Ashok, Abdullah, Shaad E., Raja, Rajiv, Frigault, Melanie M., Barrett, J. Carl, Dennis, Phillip A., Ascierto, Maria Libera, Oberst, Michael D.

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Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis von Ward, James M, Ambatipudi, Mythri, O'Hanlon, Terrance P, Smith, Michael A, de Los Reyes, Melissa, Schiffenbauer, Adam, Rahman, Saifur, Zerrouki, Kamelia, Miller, Frederick W, Sanjuan, Miguel A, Li, Jian-Liang, Casey, Kerry A, Rider, Lisa G

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Circulating Immune Cell and Outcome Analysis from the Phase 2 Study of PD-L1 Blockade with Durvalumab for Newly Diagnosed and Recurrent Glioblastoma von Nayak, Lakshmi, Standifer, Nathan, Dietrich, Jorg, Clarke, Jennifer L., Dunn, Gavin P., Lim, Michael, Cloughesy, Timothy, Gan, Hui K., Flagg, Elizabeth, George, Elizabeth, Gaffey, Sarah, Hayden, Julia, Holcroft, Christina, Wen, Patrick Y., Macri, Mary, Park, Andrew J., Ricciardi, Toni, Ryan, Aileen, Schwarzenberger, Paul, Venhaus, Ralph, de los Reyes, Melissa, Durham, Nicholas M., Creasy, Todd, Huang, Raymond Y., Kaley, Thomas, Reardon, David A.

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The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFRα-mAb treatment in rheumatoid arthritis patients von Mortensen, Joachim Høg, Guo, Xiang, De Los Reyes, Melissa, Dziegiel, Morten Hanefeld, Karsdal, Morten Asser, Bay-Jensen, Anne Christine, White, Wendy I

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Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus von Riggs, Jeffrey M, Hanna, Richard N, Rajan, Bhargavi, Zerrouki, Kamelia, Karnell, Jodi L, Sagar, Divya, Vainshtein, Inna, Farmer, Erika, Rosenthal, Kimberly, Morehouse, Chris, de los Reyes, Melissa, Schifferli, Kevin, Liang, Meina, Sanjuan, Miguel A, Sims, Gary P, Kolbeck, Roland

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Molecular biomarkers to identify patients (pts) who may benefit from durvalumab (D; anti-PD-L1) ± tremelimumab (T; anti-CTLA-4) in recurrent/metastatic head and neck squamous cell... von Li, Weimin, Matakidou, Athena, Ghazoui, Zara, Si, Han, Wildsmith, Sophie, Morsli, Nassim, Mann, Helen, Wrona, Magdalena, de Los Reyes, Melissa, Raja, Rajiv, Barker, Craig, Whiteley, Jessica, Zhang, Qu, Fayette, Jerome, Zandberg, Dan Paul, Mesia, Ricard, Siu, Lillian L.

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Atopic Dermatitis Biomarker Analysis Points to Elevation of TSLP and IL-33 Signaling and Suggests a Role for Type 2 Innate Lymphoid Cells von Griffiths, Janet, Sridhar, Sriram, Gavala, Monica, Pham, Tuyet-Hang, Ohne, Yoichiro, De Los Reyes, Melissa, Pilataxi, Fernanda, Kagiampakis, Ioannis, Parnes, Jane, KOMJATHY, STEVEN, Bronchick, Caroline, Leung, Donald, Goleva, Elena

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Biologic and clinical relevance of an IFNG mRNA signature (IFNGS) and PD-L1 protein expression in tumor and immune cells in urothelial cancer (UC) patients (pts) treated with durva... von Bais, Carlos, Kuziora, Michael, Morehouse, Chris, Higgs, Brandon W., Raja, Rajiv, Lee, Young, de Los Reyes, Melissa, Rebelatto, Marlon, Steele, Keith, Jin, Xiaoping, Shi, Li, Pilataxi, Fernanda, Ben, Yong, Antal, Joyce, Gupta, Ashok Kumar, Ranade, Koustubh

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PD-L1+ neutrophils contribute to injury-induced infection susceptibility von Thanabalasuriar, Ajitha, Chiang, Abby J., Morehouse, Christopher, Camara, Margarita, Hawkins, Shonda, Keller, Ashley E., Koksal, Adem C., Caceres, Carolina S., Berlin, Aaron A., Holoweckyj, Nicholas, Takahashi, Virginia N., Cheng, Lily, de los Reyes, Melissa, Pelletier, Mark, Patera, Andriani C., Sellman, Bret, Hess, Sonja, Marelli, Marcello, Boo, Chelsea C., Cohen, Taylor S., DiGiandomenico, Antonio

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Serine/Threonine Phosphatase Stp1 Mediates Post-transcriptional Regulation of Hemolysin, Autolysis, and Virulence of Group B Streptococcus von Burnside, Kellie, Lembo, Annalisa, Harrell, Maria Isabel, Gurney, Michael, Xue, Liang, BinhTran, Nguyen-Thao, Connelly, James E., Jewell, Kelsea A., Schmidt, Byron Z., de los Reyes, Melissa, Tao, Weiguo Andy, Doran, Kelly S., Rajagopal, Lakshmi

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