Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development von Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C

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Discovery of a Small Molecule MDM2 Inhibitor (AMG 232) for Treating Cancer von Rew, Yosup, Sun, Daqing

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Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction von Rew, Yosup, Sun, Daqing, Gonzalez-Lopez De Turiso, Felix, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Deignan, Jeffrey, Fox, Brian M, Gustin, Darin, Huang, Xin, Jiang, Min, Jiao, Xianyun, Jin, Lixia, Kayser, Frank, Kopecky, David J, Li, Yihong, Lo, Mei-Chu, Long, Alexander M, Michelsen, Klaus, Oliner, Jonathan D, Osgood, Tao, Ragains, Mark, Saiki, Anne Y, Schneider, Steve, Toteva, Maria, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Ordering of the N‑Terminus of Human MDM2 by Small Molecule Inhibitors von Michelsen, Klaus, Jordan, John B, Lewis, Jeffrey, Long, Alexander M, Yang, Evelyn, Rew, Yosup, Zhou, Jing, Yakowec, Peter, Schnier, Paul D, Huang, Xin, Poppe, Leszek

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Total Synthesis and Structure of the Ramoplanin A1 and A3 Aglycons: Two Minor Components of the Ramoplanin Complex von Shin, Dongwoo, Rew, Yosup, Boger, Dale L., Nicolaou, Kyriacos C.

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Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101) von Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Jahchan, Nadine, Zhu, Liusheng, Yan, Xuelei, Kawai, Hiroyuki, McGee, Lawrence R, Medina, Julio C, Huang, Tom, Chen, Chelsea, Zavorotinskaya, Tatiana, Sutimantanapi, Dena, Waszczuk, Joanna, Jackson, Erica, Huang, Elizabeth, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing

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Abstract 3822: ORIC-101 reverses a GR-driven EMT-like phenotype and sensitizes TNBC cells to chemotherapy von Zhou, Haiying, Sun, Jessica, Kong, Wayne, Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Sun, Daqing, Ye, Qiuping, Kabbarah, Omar, Fantin, Valeria R.

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Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere von Rescourio, Gwenaella, Gonzalez, Ana Z, Jabri, Salman, Belmontes, Brian, Moody, Gordon, Whittington, Doug, Huang, Xin, Caenepeel, Sean, Cardozo, Mario, Cheng, Alan C, Chow, David, Dou, Hannah, Jones, Adrie, Kelly, Ron C, Li, Yihong, Lizarzaburu, Mike, Lo, Mei-Chu, Mallari, Rommel, Meleza, Cesar, Rew, Yosup, Simonovich, Scott, Sun, Daqing, Turcotte, Simon, Yan, Xuelei, Wong, Simon G, Yanez, Evelyn, Zancanella, Manuel, Houze, Jonathan, Medina, Julio C, Hughes, Paul E, Brown, Sean P

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Abstract LB-115: An orally bioavailable inhibitor of CD73 reverts intratumoral immunosuppression and promotes anti-tumor responses von Metzger, Todd, Blank, Brian, Chan, Brenda, Chen, Chelsea, Chen, Yuping, Du, Xiaohui, Duong, Frank, Friedman, Lori, Junttila, Melissa, Kawai, Hiro, Kong, Wayne, Moore, Jared, Pham, Johnny, Rew, Yosup, Sun, Daqing, Sun, Jessica, Sutimantanapi, Dena, Wu, Kejia, Yeh, Chien-Hung, Yuen, Natalie, Zavorotinskaya, Tatiana

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Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction von Gonzalez, Ana Z, Eksterowicz, John, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan B, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, McMinn, Dustin L, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing

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Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633) von Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Rew, Yosup, Zhu, Liusheng, Yan, Xuelei, Medina, Julio C, Huang, Tom, Chen, Xi, Sutimantanapi, Dena, Jahchan, Nadine, Kong, Wayne, Sun, Jessica, Zavorotinskaya, Tatiana, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing

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Abstract A133: Development of murine models to evaluate the impact of glucocorticoid receptor (GR) inhibition on chemotherapy response von Jahchan, Nadine, Zhou, Haiying, Stice, James, Kong, Wayne, McWeeney, Dan, Sun, Daqing, Rew, Yosup, Du, Xiaohui, Zhu, Liusheng, Ye, Qiuping, Jackson, Erica L., Fantin, Valeria

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Abstract 1968: A novel glucocorticoid receptor (GR) antagonist overcomes GR-mediated chemoresistance in triple-negative breast cancer von Jahchan, Nadine, Zhou, Haiying, Kong, Wayne, Weeney, Dan Mc, Tracy, Ted, Stice, James, Sutimantanapi, Dena, Chen, Chelsea, Huang, Tom, Rew, Yosup, Du, Xiauhui, Zavorotinskaya, Tatiana, Sun, Daqing, Ye, Qiuping, Jackson, Erica, Fantin, Valeria

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Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors von Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction von Rew, Yosup, Sun, Daqing, Yan, Xuelei, Beck, Hilary P, Canon, Jude, Chen, Ada, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Houze, Jonathan, Huang, Xin, Jiang, Min, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Saiki, Anne Y, Shaffer, Paul, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid Isosteres von Gonzalez, Ana Z, Li, Zhihong, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan, Jin, Lixia, Li, Yihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Sun, Daqing, Medina, Julio C

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Abstract 4172: Activation of AR signaling by mifepristone enhances prostate cancer growth and impairs enzalutamide response von Zhou, Haiying, Jachan, Nadine, Singh, Mallika, Tran, Chris, McWeeney, Dan, Balbas, Minna, Schenkein, Emily, Zovorotinskaya, Tatiana, Jackson, Erica L., Medina, Julio, Sun, Daqing, Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Yan, Xuelei, Zhu, Liusheng, Ye, Qiuping, Fantin, Valeria

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Alanine Scan of [l-Dap2]Ramoplanin A2 Aglycon:  Assessment of the Importance of Each Residue von Nam, Joonwoo, Shin, Dongwoo, Rew, Yosup, Boger, Dale L

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Chemistry and Biology of Ramoplanin:  A Lipoglycodepsipeptide with Potent Antibiotic Activity von Walker, Suzanne, Chen, Lan, Hu, Yanan, Rew, Yosup, Shin, Dongwoo, Boger, Dale L

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Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors von Beck, Hilary P., DeGraffenreid, Michael, Fox, Brian, Allen, John G., Rew, Yosup, Schneider, Stephen, Saiki, Anne Y., Yu, Dongyin, Oliner, Jonathan D., Salyers, Kevin, Ye, Qiuping, Olson, Steven

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