LGG-31. CHARACTERIZING TEMPORAL GENOMIC HETEROGENEITY IN PEDIATRIC LOW GRADE GLIOMAS: ANALYSIS OF AN EXPANDED MULTI-INSTITUTIONAL COHORT WITH 101 PAIRED TUMOR SAMPLES von Lazow, Margot A, Schafer, Austin, DeWire-Schottmiller, Mariko D, Lane, Adam, Boué, Daniel R, Osorio, Diana S, Finlay, Jonathan L, Wright, Erin, Rush, Sarah, Hoffman, Lindsey M, Reuss, Jamie, Hummel, Trent R, Salloum, Ralph, de Blank, Peter M, Smiley, Natasha Pillay, Sutton, Mary E, Asher, Anthony, Stevenson, Charles B, Drissi, Rachid, Fouladi, Maryam, Fuller, Christine

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LGG-24. TEMPORAL GENOMIC HETEROGENEITY IN PEDIATRIC LOW-GRADE GLIOMAS von Fuller, Christine, Schafer, Austin, Boue, Daniel, Osorio, Diana, Finlay, Jonathan, Rush, Sarah, Wright, Erin, Hoffman, Lindsey, Yanez-Escorza, Nancy, Reuss, Jamie, Hummel, Trent, Salloum, Ralph, Chow, Lionel M L, DeWire, Mariko, de Blank, Peter, Stevenson, Charles, Drissi, Rachid, Fouladi, Maryam

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Peripheral blood immune cell dynamics reflect antitumor immune responses and predict clinical response to immunotherapy von Hwang, Michael, Canzoniero, Jenna Vanliere, Rosner, Samuel, Zhang, Guangfan, White, James R, Belcaid, Zineb, Cherry, Christopher, Balan, Archana, Pereira, Gavin, Curry, Alexandria, Niknafs, Noushin, Zhang, Jiajia, Smith, Kellie N, Sivapalan, Lavanya, Chaft, Jamie E, Reuss, Joshua E, Marrone, Kristen, Murray, Joseph C, Li, Qing Kay, Lam, Vincent, Levy, Benjamin P, Hann, Christine, Velculescu, Victor E, Brahmer, Julie R, Forde, Patrick M, Seiwert, Tanguy, Anagnostou, Valsamo

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Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non-Small Cell Lung Cancer von Rosner, Samuel, Reuss, Joshua E, Zahurak, Marianna, Zhang, Jiajia, Zeng, Zhen, Taube, Janis, Anagnostou, Valsamo, Smith, Kellie N, Riemer, Joanne, Illei, Peter B, Broderick, Stephen R, Jones, David R, Topalian, Suzanne L, Pardoll, Drew M, Brahmer, Julie R, Chaft, Jamie E, Forde, Patrick M

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Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non-Small Cell Lung Cancer von Rosner, Samuel, Reuss, Joshua E, Zahurak, Marianna, Zhang, Jiajia, Zeng, Zhen, Taube, Janis, Anagnostou, Valsamo, Smith, Kellie N, Riemer, Joanne, Illei, Peter B, Broderick, Stephen R, Jones, David R, Topalian, Suzanne L, Pardoll, Drew M, Brahmer, Julie R, Chaft, Jamie E, Forde, Patrick M

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Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non-Small Cell Lung Cancer von Zhang, Jiajia, Ji, Zhicheng, Caushi, Justina X, El Asmar, Margueritta, Anagnostou, Valsamo, Cottrell, Tricia R, Chan, Hok Yee, Suri, Prerna, Guo, Haidan, Merghoub, Taha, Chaft, Jamie E, Reuss, Joshua E, Tam, Ada J, Blosser, Richard L, Abu-Akeel, Mohsen, Sidhom, John-William, Zhao, Ni, Ha, Jinny S, Jones, David R, Marrone, Kristen A, Naidoo, Jarushka, Gabrielson, Edward, Taube, Janis M, Velculescu, Victor E, Brahmer, Julie R, Housseau, Franck, Hellmann, Matthew D, Forde, Patrick M, Pardoll, Drew M, Ji, Hongkai, Smith, Kellie N

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Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers von Caushi, Justina X., Zhang, Jiajia, Ji, Zhicheng, Vaghasia, Ajay, Zhang, Boyang, Hsiue, Emily Han-Chung, Mog, Brian J., Hou, Wenpin, Justesen, Sune, Blosser, Richard, Tam, Ada, Anagnostou, Valsamo, Cottrell, Tricia R., Guo, Haidan, Chan, Hok Yee, Singh, Dipika, Thapa, Sampriti, Dykema, Arbor G., Burman, Poromendro, Choudhury, Begum, Aparicio, Luis, Cheung, Laurene S., Lanis, Mara, Belcaid, Zineb, El Asmar, Margueritta, Illei, Peter B., Wang, Rulin, Meyers, Jennifer, Schuebel, Kornel, Gupta, Anuj, Skaist, Alyza, Wheelan, Sarah, Naidoo, Jarushka, Marrone, Kristen A., Brock, Malcolm, Ha, Jinny, Bush, Errol L., Park, Bernard J., Bott, Matthew, Jones, David R., Reuss, Joshua E., Velculescu, Victor E., Chaft, Jamie E., Kinzler, Kenneth W., Zhou, Shibin, Vogelstein, Bert, Taube, Janis M., Hellmann, Matthew D., Brahmer, Julie R., Merghoub, Taha, Forde, Patrick M., Yegnasubramanian, Srinivasan, Ji, Hongkai, Pardoll, Drew M., Smith, Kellie N.

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Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer von Reuss, Joshua E, Anagnostou, Valsamo, Cottrell, Tricia R, Smith, Kellie N, Verde, Franco, Zahurak, Marianna, Lanis, Mara, Murray, Joseph C, Chan, Hok Yee, McCarthy, Caroline, Wang, Daphne, White, James R, Yang, Stephen, Battafarano, Richard, Broderick, Stephen, Bush, Errol, Brock, Malcolm, Ha, Jinny, Jones, David, Merghoub, Taha, Taube, Janis, Velculescu, Victor E, Rosner, Gary, Illei, Peter, Pardoll, Drew M, Topalian, Suzanne, Naidoo, Jarushka, Levy, Ben, Hellmann, Matthew D, Brahmer, Julie R, Chaft, Jamie E, Forde, Patrick M

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Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors von Shaikh, Fyza Y., Gills, Joell J., Mohammad, Fuad, White, James R., Stevens, Courtney M., Ding, Hua, Fu, Juan, Tam, Ada, Blosser, Richard L., Domingue, Jada C., Larman, Tatianna C., Chaft, Jamie E., Spicer, Jonathan D., Reuss, Joshua E., Naidoo, Jarushka, Forde, Patrick M., Ganguly, Sudipto, Housseau, Franck, Pardoll, Drew M., Sears, Cynthia L.

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Neoadjuvant nivolumab in early-stage non–small cell lung cancer (NSCLC): Five-year outcomes von Rosner, Samuel, Reuss, Joshua E., Zahurak, Marianna, Taube, Janis M., Broderick, Stephen, Jones, David Randolph, Chaft, Jamie E., Forde, Patrick M.

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Response to neoadjuvant immune checkpoint inhibitor (ICI)-based therapy in oncogene-driven resectable non-small cell lung cancer (NSCLC) von Rosner, Samuel, Sivapalan, Lavanya, Zahurak, Marianna, Thummalapalli, Rohit, Rayes, Roni, Connor, Sydney, Sanber, Khaled, Reuss, Joshua E., Pereira, Gavin, Smith, Kellie Nicole, Anagnostou, Valsamo, Broderick, Stephen, Jones, David Randolph, Brahmer, Julie R., Marrone, Kristen A., Spicer, Jonathan, Chaft, Jamie E., Forde, Patrick M.

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Consolidation Osimertinib Versus Durvalumab Versus Observation After Concurrent Chemoradiation in Unresectable EGFR-Mutant NSCLC: A Multicenter Retrospective Cohort Study von Nassar, Amin H., Kim, So Yeon, Aredo, Jacqueline V., Feng, Jamie, Shepherd, Frances, Xu, Chao, Kaldas, David, Gray, Jhanelle E., Dilling, Thomas J., Neal, Joel W., Wakelee, Heather A., Liu, Yufei, Lin, Steven H., Abuali, Tariq, Amini, Arya, Nie, Yunan, Patil, Tejas, Lobachov, Anastasiya, Bar, Jair, Fitzgerald, Bailey, Fujiwara, Yu, Marron, Thomas U., Thummalapalli, Rohit, Yu, Helena, Owen, Dwight H., Sharp, John, Farid, Saira, Rocha, Pedro, Arriola, Edurne, D’Aiello, Angelica, Cheng, Haiying, Whitaker, Ryan, Parikh, Kaushal, Ashara, Yash, Chen, Luxi, Sankar, Kamya, Harris, Jeremy P., Nagasaka, Misako, Ayanambakkam, Adanma, Velazquez, Ana I., Ragavan, Meera, Lin, Jessica J., Piotrowska, Zofia, Wilgucki, Molly, Reuss, Joshua, Luders, Heike, Grohe, Christian, Baena Espinar, Javier, Feiner, Ella, Punekar, Salman R., Gupta, Shruti, Leal, Ticiana, Kwiatkowski, David J., Mak, Raymond H., Adib, Elio, Naqash, Abdul Rafeh, Goldberg, Sarah B.

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Consolidation ALK Tyrosine Kinase Inhibitors Versus Durvalumab or Observation After Chemoradiation in Unresectable Stage III ALK-Positive NSCLC von Nassar, Amin H., Jayakrishnan, Ritujith, Feng, Jamie, Shepherd, Frances, Adib, Elio, Cheung, Justin M., Lin, Jessica J., Liu, Yufei, Lin, Steven H., Parikh, Kaushal, Sridhar, Arthi, Shakya, Purnima, Dilling, Thomas J., Kaldas, David, Gray, Jhanelle E., Lobachov, Anastasiya, Bar, Jair, Luders, Heike, Grohe, Christian, Gupta, Shruti, Leal, Ticiana, Fitzgerald, Bailey, Crowley, Fionnuala, Fujiwara, Yu, Marron, Thomas U., Wilgucki, Molly, Reuss, Joshua, Chen, Luxi, Sankar, Kamya, Aredo, Jacqueline V., Neal, Joel W., Wakelee, Heather A., Thummalapalli, Rohit, Yu, Helena, Whitaker, Ryan, Velazquez, Ana, Ragavan, Meera, Cortellini, Alessio, Kwiatkowski, David J., Naqash, Abdul Rafeh, Goldberg, Sarah B., Kim, So Yeon

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Neoadjuvant nivolumab in resectable non-small cell lung cancer: Extended follow-up and molecular markers of response von Reuss, Joshua E., Smith, Kellie Nicole, Anagnostou, Valsamo, Zhang, Jiajia, Zahurak, Marianna, Caushi, Justina, Chan, Hok Yee, Guo, Haidan, Hellmann, Matthew David, Pardoll, Drew M., Brahmer, Julie R., Chaft, Jamie E., Forde, Patrick M.

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Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers von Caushi, Justina X, Zhang, Jiajia, Ji, Zhicheng, Vaghasia, Ajay, Zhang, Boyang, Hsiue, Emily Han-Chung, Mog, Brian J, Hou, Wenpin, Justesen, Sune, Blosser, Richard, Tam, Ada, Anagnostou, Valsamo, Cottrell, Tricia R, Guo, Haidan, Chan, Hok Yee, Singh, Dipika, Thapa, Sampriti, Dykema, Arbor G, Burman, Poromendro, Choudhury, Begum, Aparicio, Luis, Cheung, Laurene S, Lanis, Mara, Belcaid, Zineb, Asmar, Margueritta El, Illei, Peter B, Wang, Rulin, Meyers, Jennifer, Schuebe, Kornel, Gupta, Anuj, Skaist, Alyza, Wheelan, Sarah, Naidoo, Jarushka, Marrone, Kristen A, Brock, Malcolm, Ha, Jinny, Bush, Errol L, Park, Bernard J, Bott, Matthew, Jones, David R, Reuss, Joshua E, Velculescu, Victor E, Chaft, Jamie E, Kinzler, Kenneth W, Zhou, Shibin, Vogelstein, Bert, Taube, Janis M, Hellmann, Matthew D, Brahmer, Julie R, Merghoub, Taha, de, Patrick M, Yegnasubramanian, Srinivasan, Ji, Hongkai, Pardoll, Drew M, Smith, Kellie N

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Consolidation ALK Tyrosine Kinase Inhibitors versus Durvalumab or Observation After Chemoradiation in Unresectable Stage III ALK+ Non-Small Cell Lung Cancer von Nassar, Amin H, Jayakrishnan, Ritujith, Feng, Jamie, Shepherd, Frances, Adib, Elio, Cheung, Justin M, Lin, Jessica J, Liu, Yufei, Lin, Steven H, Parikh, Kaushal, Sridhar, Arthi, Shakya, Purnima, Dilling, Thomas J, Kaldas, David, Gray, Jhanelle E, Lobachov, Anastasiya, Bar, Jair, Luders, Heike, Grohe, Christian, Gupta, Shruti, Leal, Ticiana, Fitzgerald, Bailey, Crowley, Fionnuala, Fujiwara, Yu, Marron, Thomas U, Wilgucki, Molly, Reuss, Joshua, Chen, Luxi, Sankar, Kamya, Aredo, Jacqueline V, Neal, Joel W, Wakelee, Heather A, Thummalapalli, Rohit, Yu, Helena, Whitaker, Ryan, Velazquez, Ana, Ragavan, Meera, Cortellini, Alessio, Kwiatkowski, David J, Naqash, Abdul Rafeh, Goldberg, Sarah B, Kim, So Yeon

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