BET inhibition disrupts transcription but retains enhancer-promoter contact von Crump, Nicholas T., Ballabio, Erica, Godfrey, Laura, Thorne, Ross, Repapi, Emmanouela, Kerry, Jon, Tapia, Marta, Hua, Peng, Lagerholm, Christoffer, Filippakopoulos, Panagis, Davies, James O. J., Milne, Thomas A.

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Single-cell atlas of colonic CD8+ T cells in ulcerative colitis von Corridoni, Daniele, Antanaviciute, Agne, Gupta, Tarun, Fawkner-Corbett, David, Aulicino, Anna, Jagielowicz, Marta, Parikh, Kaushal, Repapi, Emmanouela, Taylor, Steve, Ishikawa, Dai, Hatano, Ryo, Yamada, Taketo, Xin, Wei, Slawinski, Hubert, Bowden, Rory, Napolitani, Giorgio, Brain, Oliver, Morimoto, Chikao, Koohy, Hashem, Simmons, Alison

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Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells von Karamitros, Dimitris, Stoilova, Bilyana, Aboukhalil, Zahra, Hamey, Fiona, Reinisch, Andreas, Samitsch, Marina, Quek, Lynn, Otto, Georg, Repapi, Emmanouela, Doondeea, Jessica, Usukhbayar, Batchimeg, Calvo, Julien, Taylor, Stephen, Goardon, Nicolas, Six, Emmanuelle, Pflumio, Francoise, Porcher, Catherine, Majeti, Ravindra, Göttgens, Berthold, Vyas, Paresh

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From Pioneer to Repressor: Bimodal foxd3 Activity Dynamically Remodels Neural Crest Regulatory Landscape In Vivo von Lukoseviciute, Martyna, Gavriouchkina, Daria, Williams, Ruth M., Hochgreb-Hagele, Tatiana, Senanayake, Upeka, Chong-Morrison, Vanessa, Thongjuea, Supat, Repapi, Emmanouela, Mead, Adam, Sauka-Spengler, Tatjana

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DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation von Godfrey, Laura, Crump, Nicholas T., Thorne, Ross, Lau, I-Jun, Repapi, Emmanouela, Dimou, Dimitra, Smith, Alastair L., Harman, Joe R., Telenius, Jelena M., Oudelaar, A. Marieke, Downes, Damien J., Vyas, Paresh, Hughes, Jim R., Milne, Thomas A.

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The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin von Truch, Julia, Downes, Damien J., Scott, Caroline, Gür, E. Ravza, Telenius, Jelena M., Repapi, Emmanouela, Schwessinger, Ron, Gosden, Matthew, Brown, Jill M., Taylor, Stephen, Cheong, Pak Leng, Hughes, Jim R., Higgs, Douglas R., Gibbons, Richard J.

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Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease von Gooding, Sarah, Olechnowicz, Sam W. Z., Morris, Emma V., Armitage, Andrew E., Arezes, Joao, Frost, Joe, Repapi, Emmanouela, Edwards, James R., Ashley, Neil, Waugh, Craig, Gray, Nicola, Martinez-Hackert, Erik, Lim, Pei Jin, Pasricha, Sant-Rayn, Knowles, Helen, Mead, Adam J., Ramasamy, Karthik, Drakesmith, Hal, Edwards, Claire M.

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Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype von Fraser, Emily, Denney, Laura, Antanaviciute, Agne, Blirando, Karl, Vuppusetty, Chaitanya, Zheng, Yuejuan, Repapi, Emmanouela, Iotchkova, Valentina, Taylor, Stephen, Ashley, Neil, St Noble, Victoria, Benamore, Rachel, Hoyles, Rachel, Clelland, Colin, Rastrick, Joseph M D, Hardman, Clare S, Alham, Nasullah K, Rigby, Rachel E, Simmons, Alison, Rehwinkel, Jan, Ho, Ling-Pei

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Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs von Weeratunga, Praveen, Denney, Laura, Bull, Joshua A., Repapi, Emmanouela, Sergeant, Martin, Etherington, Rachel, Vuppussetty, Chaitanya, Turner, Gareth D. H., Clelland, Colin, Woo, Jeongmin, Cross, Amy, Issa, Fadi, de Andrea, Carlos Eduardo, Melero Bermejo, Ignacio, Sims, David, McGowan, Simon, Zurke, Yasemin-Xiomara, Ahern, David J., Gamez, Eddie C., Whalley, Justin, Richards, Duncan, Klenerman, Paul, Monaco, Claudia, Udalova, Irina A., Dong, Tao, Antanaviciute, Agne, Ogg, Graham, Knight, Julian C., Byrne, Helen M., Taylor, Stephen, Ho, Ling-Pei

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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia von Kerry, Jon, Godfrey, Laura, Repapi, Emmanouela, Tapia, Marta, Blackledge, Neil P., Ma, Helen, Ballabio, Erica, O’Byrne, Sorcha, Ponthan, Frida, Heidenreich, Olaf, Roy, Anindita, Roberts, Irene, Konopleva, Marina, Klose, Robert J., Geng, Huimin, Milne, Thomas A.

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SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells von Chagraoui, Hedia, Kristiansen, Maiken S., Ruiz, Juan Pablo, Serra-Barros, Ana, Richter, Johanna, Hall-Ponselé, Elisa, Gray, Nicki, Waithe, Dominic, Clark, Kevin, Hublitz, Philip, Repapi, Emmanouela, Otto, Georg, Sopp, Paul, Taylor, Stephen, Thongjuea, Supat, Vyas, Paresh, Porcher, Catherine

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Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation von Mead, Adam J, Neo, Wen Hao, Barkas, Nikolaos, Matsuoka, Sahoko, Giustacchini, Alice, Facchini, Raffaella, Thongjuea, Supat, Jamieson, Lauren, Booth, Christopher A G, Fordham, Nicholas, Di Genua, Cristina, Atkinson, Deborah, Chowdhury, Onima, Repapi, Emmanouela, Gray, Nicki, Kharazi, Shabnam, Clark, Sally-Ann, Bouriez, Tiphaine, Woll, Petter, Suda, Toshio, Nerlov, Claus, Jacobsen, Sten Eirik W

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Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation von Di Genua, Cristina, Norfo, Ruggiero, Rodriguez-Meira, Alba, Wen, Wei Xiong, Drissen, Roy, Booth, Christopher A G, Povinelli, Benjamin, Repapi, Emmanouela, Gray, Nicki, Carrelha, Joana, Kettyle, Laura M, Jamieson, Lauren, Neo, Wen Hao, Thongjuea, Supat, Nerlov, Claus, Mead, Adam J

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Does osteogenic potential of clonal human bone marrow mesenchymal stem/stromal cells correlate with their vascular supportive ability? von Merryweather-Clarke, Alison T, Cook, David, Lara, Barbara Joo, Hua, Peng, Repapi, Emmanouela, Ashley, Neil, Lim, Shiang Y, Watt, Suzanne M

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No evidence for age-related differences in mitochondrial RNA quality in the female germline von Hartley, Fiona, Alageel, Arwa, Appeltant, Ruth, Gray, Nicki, Repapi, Emmanouela, Wells, Dagan, Williams, Suzannah A, Poulton, Joanna

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A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample von Obeidat, Ma'en, Wain, Louise V, Shrine, Nick, Kalsheker, Noor, Soler Artigas, Maria, Repapi, Emmanouela, Burton, Paul R, Johnson, Toby, Ramasamy, Adaikalavan, Zhao, Jing Hua, Zhai, Guangju, Huffman, Jennifer E, Vitart, Veronique, Albrecht, Eva, Igl, Wilmar, Hartikainen, Anna-Liisa, Pouta, Anneli, Cadby, Gemma, Hui, Jennie, Palmer, Lyle J, Hadley, David, McArdle, Wendy L, Rudnicka, Alicja R, Barroso, Inês, Loos, Ruth J F, Wareham, Nicholas J, Mangino, Massimo, Soranzo, Nicole, Spector, Tim D, Gläser, Sven, Homuth, Georg, Völzke, Henry, Deloukas, Panos, Granell, Raquel, Henderson, John, Grkovic, Ivica, Jankovic, Stipan, Zgaga, Lina, Polašek, Ozren, Rudan, Igor, Wright, Alan F, Campbell, Harry, Wild, Sarah H, Wilson, James F, Heinrich, Joachim, Imboden, Medea, Probst-Hensch, Nicole M, Gyllensten, Ulf, Johansson, Åsa, Zaboli, Ghazal, Mustelin, Linda, Rantanen, Taina, Surakka, Ida, Kaprio, Jaakko, Jarvelin, Marjo-Riitta, Hayward, Caroline, Evans, David M, Koch, Beate, Musk, Arthur William, Elliott, Paul, Strachan, David P, Tobin, Martin D, Sayers, Ian, Hall, Ian P

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The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes von Yip, Bon Ham, Steeples, Violetta, Repapi, Emmanouela, Armstrong, Richard N, Llorian, Miriam, Roy, Swagata, Shaw, Jacqueline, Dolatshad, Hamid, Taylor, Stephen, Verma, Amit, Bartenstein, Matthias, Vyas, Paresh, Cross, Nicholas Cp, Malcovati, Luca, Cazzola, Mario, Hellström-Lindberg, Eva, Ogawa, Seishi, Smith, Christopher Wj, Pellagatti, Andrea, Boultwood, Jacqueline

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A Comprehensive Analysis of the Impact of HIV on HCV Immune Responses and Its Association with Liver Disease Progression in a Unique Plasma Donor Cohort von Zhang, Yong-Hong, Zhao, Yan, Rajapaksa, Ushani S, Lawrence, Tessa M, Peng, Yan-Chun, Liu, Jinghua, Xu, Keyi, Hu, Ke, Qin, Ling, Liu, Ning, Sun, Huanqin, Yan, Hui-Ping, Repapi, Emmanouela, Rowland-Jones, Sarah, Thimme, Robert, McKeating, Jane A, Dong, Tao

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Reconstruction of the Global Neural Crest Gene Regulatory Network In Vivo von Williams, Ruth M., Candido-Ferreira, Ivan, Repapi, Emmanouela, Gavriouchkina, Daria, Senanayake, Upeka, Ling, Irving T.C., Telenius, Jelena, Taylor, Stephen, Hughes, Jim, Sauka-Spengler, Tatjana

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Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells von Monteiro, Rui, Pinheiro, Philip, Joseph, Nicola, Peterkin, Tessa, Koth, Jana, Repapi, Emmanouela, Bonkhofer, Florian, Kirmizitas, Arif, Patient, Roger

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