Discovery and development of orexin receptor antagonists as therapeutics for insomnia von Winrow, C J, Renger, J J

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Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons von Jacus, Megan O, Uebele, Victor N, Renger, John J, Todorovic, Slobodan M

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Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells von Usenovic, Marija, Niroomand, Shahriar, Drolet, Robert E, Yao, Lihang, Gaspar, Renee C, Hatcher, Nathan G, Schachter, Joel, Renger, John J, Parmentier-Batteur, Sophie

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The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia von Coleman, Paul J, Gotter, Anthony L, Herring, W. Joseph, Winrow, Christopher J, Renger, John J

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Three-dimensional manipulation with scanning near-field optical nanotweezers von Berthelot, J., Aćimović, S. S., Juan, M. L., Kreuzer, M. P., Renger, J., Quidant, R.

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Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors von Yin, Jie, Babaoglu, Kerim, Brautigam, Chad A, Clark, Lindsay, Shao, Zhenhua, Scheuermann, Thomas H, Harrell, Charles M, Gotter, Anthony L, Roecker, Anthony J, Winrow, Christopher J, Renger, John J, Coleman, Paul J, Rosenbaum, Daniel M

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Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease von Zhou, Yuan, Hayashi, Ikuo, Wong, Jacky, Tugusheva, Katherine, Renger, John J, Zerbinatti, Celina

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International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology von Gotter, Anthony L, Webber, Andrea L, Coleman, Paul J, Renger, John J, Winrow, Christopher J

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Essential thalamic contribution to slow waves of natural sleep von David, François, Schmiedt, Joscha T, Taylor, Hannah L, Orban, Gergely, Di Giovanni, Giuseppe, Uebele, Victor N, Renger, John J, Lambert, Régis C, Leresche, Nathalie, Crunelli, Vincenzo

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Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for... von Cox, Christopher D, Breslin, Michael J, Whitman, David B, Schreier, John D, McGaughey, Georgia B, Bogusky, Michael J, Roecker, Anthony J, Mercer, Swati P, Bednar, Rodney A, Lemaire, Wei, Bruno, Joseph G, Reiss, Duane R, Harrell, C. Meacham, Murphy, Kathy L, Garson, Susan L, Doran, Scott M, Prueksaritanont, Thomayant, Anderson, Wayne B, Tang, Cuyue, Roller, Shane, Cabalu, Tamara D, Cui, Donghui, Hartman, George D, Young, Steven D, Koblan, Ken S, Winrow, Christopher J, Renger, John J, Coleman, Paul J

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Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress von Grafe, Laura A, Eacret, Darrell, Luz, Sandra, Gotter, Anthony L, Renger, John J, Winrow, Chris J, Bhatnagar, Seema

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GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons von Sun, Yan-Gang, Wu, Chia-Shan, Renger, John J, Uebele, Victor N, Lu, Hui-Chen, Beierlein, Michael

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Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses von Huang, Zhuo, Lujan, Rafael, Kadurin, Ivan, Uebele, Victor N, Renger, John J, Dolphin, Annette C, Shah, Mala M

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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man von Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.

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Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease von Cramer, Paige E., Gentzel, Renee C., Tanis, Keith Q., Vardigan, Joshua, Wang, Yi, Connolly, Brett, Manfre, Philip, Lodge, Kenneth, Renger, John J., Zerbinatti, Celina, Uslaner, Jason M.

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Deep-subwavelength imaging of the modal dispersion of light von Sapienza, R., Coenen, T., Renger, J., Kuttge, M., van Hulst, N. F., Polman, A.

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Calcineurin signaling mediates activity-dependent relocation of the axon initial segment von Evans, Mark D, Sammons, Rosanna P, Lebron, Sabrina, Dumitrescu, Adna S, Watkins, Thomas B K, Uebele, Victor N, Renger, John J, Grubb, Matthew S

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Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey von Vardigan, Joshua D., Cannon, Christopher E., Puri, Vanita, Dancho, Mandy, Koser, AmyJo, Wittmann, Marion, Kuduk, Scott D., Renger, John J., Uslaner, Jason M.

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Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys von Tannenbaum, Pamela L, Tye, Spencer J, Stevens, Joanne, Gotter, Anthony L, Fox, Steven V, Savitz, Alan T, Coleman, Paul J, Uslaner, Jason M, Kuduk, Scott D, Hargreaves, Richard, Winrow, Christopher J, Renger, John J

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Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia von Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Tannenbaum, Pamela L., Garson, Susan L., Doran, Scott M., Breslin, Michael J., Schreier, John D., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.

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