Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue von Véniant, Murielle M., Sivits, Glenn, Helmering, Joan, Komorowski, Renee, Lee, Jae, Fan, Wei, Moyer, Carolyn, Lloyd, David J.

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Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys von Véniant, Murielle M, Komorowski, Renee, Chen, Ping, Stanislaus, Shanaka, Winters, Katherine, Hager, Todd, Zhou, Lei, Wada, Russell, Hecht, Randy, Xu, Jing

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors von Lloyd, David J., St Jean, David J., Kurzeja, Robert J. M., Wahl, Robert C., Michelsen, Klaus, Cupples, Rod, Chen, Michelle, Wu, John, Sivits, Glenn, Helmering, Joan, Komorowski, Renée, Ashton, Kate S., Pennington, Lewis D., Fotsch, Christopher, Vazir, Mukta, Chen, Kui, Chmait, Samer, Zhang, Jiandong, Liu, Longbin, Norman, Mark H., Andrews, Kristin L., Bartberger, Michael D., Van, Gwyneth, Galbreath, Elizabeth J., Vonderfecht, Steven L., Wang, Minghan, Jordan, Steven R., Véniant, Murielle M., Hale, Clarence

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GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys von Lu, Shu-Chen, Chen, Michelle, Atangan, Larissa, Killion, Elizabeth A., Komorowski, Renee, Cheng, Yuan, Netirojjanakul, Chawita, Falsey, James R., Stolina, Marina, Dwyer, Denise, Hale, Clarence, Stanislaus, Shanaka, Hager, Todd, Thomas, Veena A., Harrold, John M., Lloyd, David J., Véniant, Murielle M.

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Enhancement of therapeutic protein in vivo activities through glycoengineering von Elliott, Steve, Lorenzini, Tony, Asher, Sheilah, Aoki, Ken, Brankow, David, Buck, Lynette, Busse, Leigh, Chang, David, Fuller, Janis, Grant, James, Hernday, Natasha, Hokum, Martha, Hu, Sylvia, Knudten, Andrew, Levin, Nancy, Komorowski, Renee, Martin, Frank, Navarro, Rachell, Osslund, Timothy, Rogers, Gary, Rogers, Norma, Trail, Geri, Egrie, Joan

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FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein von Smith, Richard, Duguay, Amy, Bakker, Alice, Li, Peng, Weiszmann, Jennifer, Thomas, Melissa R, Alba, Benjamin M, Wu, Xinle, Gupte, Jamila, Yang, Li, Stevens, Jennitte, Hamburger, Agnes, Smith, Stephen, Chen, Jiyun, Komorowski, Renee, Moore, Kevin W, Véniant, Murielle M, Li, Yang

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Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperg... von Gu, Wei, Yan, Hai, Winters, Katherine A, Komorowski, Renée, Vonderfecht, Steven, Atangan, Larissa, Sivits, Glenn, Hill, David, Yang, Jie, Bi, Vivian, Shen, Yuqing, Hu, Sylvia, Boone, Tom, Lindberg, Richard A, Véniant, Murielle M

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Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys von Yan, Hai, Gu, Wei, Yang, Jie, Bi, Vivian, Shen, Yuqing, Lee, Eunkyung, Winters, Katherine A, Komorowski, Renée, Zhang, Cheng, Patel, Jennifer J, Caughey, Dorothy, Elliott, Gary S, Lau, Yvonne Y, Wang, Jin, Li, Yue-Sheng, Boone, Tom, Lindberg, Richard A, Hu, Sylvia, Véniant, Murielle M

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Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice von Gu, Wei, Lloyd, David J, Chinookswong, Narumol, Komorowski, Renée, Sivits, Jr, Glenn, Graham, Melissa, Winters, Katherine A, Yan, Hai, Boros, Laszlo G, Lindberg, Richard A, Véniant, Murielle M

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An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice von Lu, Shu-Chen, Atangan, Larissa, Won Kim, Ki, Chen, Michelle M., Komorowski, Renee, Chu, Carolyn, Han, Joon, Hu, Sylvia, Gu, Wei, Véniant, Murielle, Wang, Minghan

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Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor von Gu, Wei, Winters, Katherine A, Motani, Alykhan S, Komorowski, Renée, Zhang, Ying, Liu, Qingxiang, Wu, Xiaosu, Rulifson, Ingrid C, Sivits, Jr, Glenn, Graham, Melissa, Yan, Hai, Wang, Paul, Moore, Steve, Meng, Tina, Lindberg, Richard A, Véniant, Murielle M

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Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-iso... von Véniant, Murielle M, Hale, Clarence, Hungate, Randall W, Gahm, Kyung, Emery, Maurice G, Jona, Janan, Joseph, Smriti, Adams, Jeffrey, Hague, Andrew, Moniz, George, Zhang, Jiandong, Bartberger, Michael D, Li, Vivian, Syed, Rashid, Jordan, Steven, Komorowski, Renée, Chen, Michelle M, Cupples, Rod, Kim, Ki Won, St. Jean, David J, Johansson, Lars, Henriksson, Martin A, Williams, Meredith, Vallgårda, Jerk, Fotsch, Christopher, Wang, Minghan

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A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings von Véniant, Murielle M., Lu, Shu-Chen, Atangan, Larissa, Komorowski, Renee, Stanislaus, Shanaka, Cheng, Yuan, Wu, Bin, Falsey, James R., Hager, Todd, Thomas, Veena A., Ambhaikar, Malhar, Sharpsten, Lucie, Zhu, Yineng, Kurra, Vamsi, Jeswani, Rohini, Oberoi, Rajneet K., Parnes, Jane R., Honarpour, Narimon, Neutel, Joel, Strande, Jennifer L.

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Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase von Bourbeau, Matthew P, Siegmund, Aaron, Allen, John G, Shu, Hong, Fotsch, Christopher, Bartberger, Michael D, Kim, Ki-Won, Komorowski, Renee, Graham, Melissa, Busby, James, Wang, Minghan, Meyer, James, Xu, Yang, Salyers, Kevin, Fielden, Mark, Véniant, Murielle M, Gu, Wei

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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties von Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter

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2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic E... von Johansson, Lars, Fotsch, Christopher, Bartberger, Michael D, Castro, Victor M, Chen, Michelle, Emery, Maurice, Gustafsson, Sonja, Hale, Clarence, Hickman, Dean, Homan, Evert, Jordan, Steven R, Komorowski, Renee, Li, Aiwen, McRae, Kenneth, Moniz, George, Matsumoto, Guy, Orihuela, Carlos, Palm, Gunnar, Veniant, Murielle, Wang, Minghan, Williams, Meredith, Zhang, Jiandong

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FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/[beta]-Klotho Bispecific Protein von Smith, Richard, Duguay, Amy, Bakker, Alice, Li, Peng, Weiszmann, Jennifer, Thomas, Melissa R, Alba, Benjamin M, Wu, Xinle, Gupte, Jamila, Yang, Li, Stevens, Jennitte, Hamburger, Agnes, Smith, Stephen, Chen, Jiyun, Komorowski, Renee, Moore, Kevin W, Véniant, Murielle M, Li, Yang

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2-(S)-Phenethylaminothiazolones as Potent, Orally Efficacious Inhibitors of 11β-Hydroxysteriod Dehydrogenase Type 1 von St. Jean, David J, Yuan, Chester, Bercot, Eric A, Cupples, Rod, Chen, Michelle, Fretland, Jenne, Hale, Clarence, Hungate, Randall W, Komorowski, Renee, Veniant, Murielle, Wang, Minghan, Zhang, Xiping, Fotsch, Christopher

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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394 von Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter

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Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in... von Fotsch, Christopher, Bartberger, Michael D, Bercot, Eric A, Chen, Michelle, Cupples, Rod, Emery, Maury, Fretland, Jenne, Guram, Anil, Hale, Clarence, Han, Nianhe, Hickman, Dean, Hungate, Randall W, Hayashi, Michael, Komorowski, Renee, Liu, Qingyian, Matsumoto, Guy, St. Jean, David J, Ursu, Stefania, Véniant, Murielle, Xu, Guifen, Ye, Qiuping, Yuan, Chester, Zhang, Jiandong, Zhang, Xiping, Tu, Hua, Wang, Minghan

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