Cryo-EM in drug discovery: achievements, limitations and prospects von Renaud, Jean-Paul, Chari, Ashwin, Ciferri, Claudio, Liu, Wen-ti, Rémigy, Hervé-William, Stark, Holger, Wiesmann, Christian

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Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni von Marek, Martin, Kannan, Srinivasaraghavan, Hauser, Alexander-Thomas, Moraes Mourão, Marina, Caby, Stéphanie, Cura, Vincent, Stolfa, Diana A, Schmidtkunz, Karin, Lancelot, Julien, Andrade, Luiza, Renaud, Jean-Paul, Oliveira, Guilherme, Sippl, Wolfgang, Jung, Manfred, Cavarelli, Jean, Pierce, Raymond J, Romier, Christophe

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One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists von Schiebel, Johannes, Radeva, Nedyalka, Köster, Helene, Metz, Alexander, Krotzky, Timo, Kuhnert, Maren, Diederich, Wibke E., Heine, Andreas, Neumann, Lars, Atmanene, Cedric, Roecklin, Dominique, Vivat-Hannah, Valérie, Renaud, Jean-Paul, Meinecke, Robert, Schlinck, Nina, Sitte, Astrid, Popp, Franziska, Zeeb, Markus, Klebe, Gerhard

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Biophysics in drug discovery: impact, challenges and opportunities von Renaud, Jean-Paul, Chung, Chun-wa, Danielson, U. Helena, Egner, Ursula, Hennig, Michael, Hubbard, Roderick E., Nar, Herbert

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Structural and Functional Evidence for Ligand-Independent Transcriptional Activation by the Estrogen-Related Receptor 3 von Greschik, Holger, Wurtz, Jean-Marie, Sanglier, Sarah, Bourguet, William, van Dorsselaer, Alain, Moras, Dino, Renaud, Jean-Paul

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In Silico Fragment-Based Drug Discovery: Setup and Validation of a Fragment-to-Lead Computational Protocol Using S4MPLE von Hoffer, Laurent, Renaud, Jean-Paul, Horvath, Dragos

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X-ray structure of the orphan nuclear receptor RORβ ligand-binding domain in the active conformation von Stehlin, Catherine, Wurtz, Jean-Marie, Steinmetz, Anke, Greiner, Erich, Schüle, Roland, Moras, Dino, Renaud, Jean-Paul

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Biophysical techniques for ligand screening and drug design von Renaud, Jean-Paul, Delsuc, Marc-André

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Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP von Vichi, Paul, Coin, Frédéric, Renaud, Jean-Paul, Vermeulen, Wim, Hoeijmakers, J.H.J, Moras, Dino, Egly, Jean-Marc

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Structure–function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients von Lehmann, Sylvia G., Wurtz, Jean-Marie, Renaud, Jean-Paul, Sassone-Corsi, Paolo, Lalli, Enzo

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Amphioxus Postembryonic Development Reveals the Homology of Chordate Metamorphosis von Paris, Mathilde, Escriva, Hector, Schubert, Michael, Brunet, Frédéric, Brtko, Julius, Ciesielski, Fabrice, Roecklin, Dominique, Vivat-Hannah, Valérie, Jamin, Emilien L., Cravedi, Jean-Pierre, Scanlan, Thomas S., Renaud, Jean-Paul, Holland, Nicholas D., Laudet, Vincent

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Structural Basis for the Deactivation of the Estrogen-related Receptor γ by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity von Greschik, Holger, Flaig, Ralf, Renaud, Jean-Paul, Moras, Dino

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All- trans retinoic acid is a ligand for the orphan nuclear receptor RORβ von Moras, Dino, Stehlin-Gaon, Catherine, Willmann, Dominica, Zeyer, Denis, Sanglier, Sarah, Van Dorsselaer, Alain, Renaud, Jean-Paul, Schüle, Roland

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Using nondenaturing mass spectrometry to detect fortuitous ligands in orphan nuclear receptors von Potier, Noelle, Billas, Isabelle M.L., Steinmetz, Anke, Schaeffer, Christine, van Dorsselaer, Alain, Moras, Dino, Renaud, Jean‐Paul

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Crystal structure of the RAR-γ ligand-binding domain bound to all- trans retinoic acid von Renaud, Jean-Paul, Rochel, Natacha, Ruff, Marc, Vivat, Valéria, Chambon, Pierre, Gronemeyer, Hinrich, Moras, Dino

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The pleiotropic functions of peroxisome proliferator-activated receptor γ von DEBRIL, Marie-Bernard, RENAUD, Jean-Paul, FAJAS, Lluis, AUWERX, Johan

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A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity von Rocchi, Stéphane, Picard, Frédéric, Vamecq, Joseph, Gelman, Laurent, Potier, Noelle, Zeyer, Denis, Dubuquoy, Laurent, Bac, Pierre, Champy, Marie-France, Plunket, Kelli D., Leesnitzer, Lisa M., Blanchard, Steven G., Desreumaux, Pierre, Moras, Dino, Renaud, Jean-Paul, Auwerx, Johan

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Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy von Davydov, Dmitri R, Halpert, James R, Renaud, Jean-Paul, Hui Bon Hoa, Gaston

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Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors von Ferry, Gilles, Studeny, Aurélie, Bossard, Céline, Kubara, Philip M., Zeyer, Denis, Renaud, Jean-Paul, Casara, Patrick, de Nanteuil, Guillaume, Wierzbicki, Michel, Pfeiffer, Bruno, Prudhomme, Michelle, Leonce, Stephane, Pierré, Alain, Boutin, Jean A., Golsteyn, Roy M.

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Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORγ von Kurebayashi, Shogo, Nakajima, Takeshi, Kim, Seong-Chul, Chang, Ching-Yi, McDonnell, Donald P., Renaud, Jean-Paul, Jetten, Anton M.

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