Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells von Remsing Rix, L L, Rix, U, Colinge, J, Hantschel, O, Bennett, K L, Stranzl, T, Müller, A, Baumgartner, C, Valent, P, Augustin, M, Till, J H, Superti-Furga, G

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IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells von Remsing Rix, Lily L, Sumi, Natalia J, Hu, Qianqian, Desai, Bina, Bryant, Annamarie T, Li, Xueli, Welsh, Eric A, Fang, Bin, Kinose, Fumi, Kuenzi, Brent M, Chen, Y Ann, Antonia, Scott J, Lovly, Christine M, Koomen, John M, Haura, Eric B, Marusyk, Andriy, Rix, Uwe

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Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets von Rix, Uwe, Hantschel, Oliver, Dürnberger, Gerhard, Remsing Rix, Lily L., Planyavsky, Melanie, Fernbach, Nora V., Kaupe, Ines, Bennett, Keiryn L., Valent, Peter, Colinge, Jacques, Köcher, Thomas, Superti-Furga, Giulio

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Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia von Kuenzi, Brent M., Remsing Rix, Lily L., Kinose, Fumi, Kroeger, Jodi L., Lancet, Jeffrey E., Padron, Eric, Rix, Uwe

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Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets von Knezevic, Claire E., Wright, Gabriela, Remsing Rix, Lily L., Kim, Woosuk, Kuenzi, Brent M., Luo, Yunting, Watters, January M., Koomen, John M., Haura, Eric B., Monteiro, Alvaro N., Radu, Caius, Lawrence, Harshani R., Rix, Uwe

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Chemoproteomics Reveals Novel Protein and Lipid Kinase Targets of Clinical CDK4/6 Inhibitors in Lung Cancer von Sumi, Natalia J, Kuenzi, Brent M, Knezevic, Claire E, Remsing Rix, Lily L, Rix, Uwe

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Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach von Fang, Bin, Izumi, Victoria, Rix, Lily L. Remsing, Welsh, Eric, Pike, Ian, Reuther, Gary W., Haura, Eric B., Rix, Uwe, Koomen, John M.

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Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells von Kim, Jae-Young, Welsh, Eric A., Oguz, Umut, Fang, Bin, Bai, Yun, Kinose, Fumi, Bronk, Crystina, Rix, Lily L. Remsing, Beg, Amer A., Rix, Uwe, Eschrich, Steven A., Koomen, John M., Haura, Eric B.

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Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity von Wright, Gabriela, Golubeva, Volha, Remsing Rix, Lily L, Berndt, Norbert, Luo, Yunting, Ward, Grace A, Gray, Jhanelle E, Schonbrunn, Ernst, Lawrence, Harshani R, Monteiro, Alvaro N.A, Rix, Uwe

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GSK3 Alpha and Beta Are New Functionally Relevant Targets of Tivantinib in Lung Cancer Cells von Remsing Rix, Lily L, Kuenzi, Brent M, Luo, Yunting, Remily-Wood, Elizabeth, Kinose, Fumi, Wright, Gabriela, Li, Jiannong, Koomen, John M, Haura, Eric B, Lawrence, Harshani R, Rix, Uwe

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Dabrafenib inhibits the growth of BRAF‐WT cancers through CDK16 and NEK9 inhibition von Phadke, Manali, Remsing Rix, Lily L., Smalley, Inna, Bryant, Annamarie T., Luo, Yunting, Lawrence, Harshani R., Schaible, Braydon J., Chen, Yian A., Rix, Uwe, Smalley, Keiran S. M.

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A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells von Rix, U, Remsing Rix, L L, Terker, A S, Fernbach, N V, Hantschel, O, Planyavsky, M, Breitwieser, F P, Herrmann, H, Colinge, J, Bennett, K L, Augustin, M, Till, J H, Heinrich, M C, Valent, P, Superti-Furga, G

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Polypharmacology-based ceritinib repurposing using integrated functional proteomics von Kuenzi, Brent M, Remsing Rix, Lily L, Stewart, Paul A, Fang, Bin, Kinose, Fumi, Bryant, Annamarie T, Boyle, Theresa A, Koomen, John M, Haura, Eric B, Rix, Uwe

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Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2 von Liao, Yi, Remsing Rix, Lily L., Li, Xueli, Fang, Bin, Izumi, Victoria, Welsh, Eric A., Monastyrskyi, Andrii, Haura, Eric B., Koomen, John M., Doebele, Robert C., Rix, Uwe

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Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model von Sarcar, Bhaswati, Gimbrone, Nicholas T., Wright, Gabriela, Remsing Rix, Lily L., Gordian, Edna R., Rix, Uwe, Chiappori, Alberto A., Reuther, Gary W., Santiago‐Cardona, Pedro G., Muñoz‐Antonia, Teresita, Cress, William Douglas

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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets von Sumi, Natalia J., Ctortecka, Claudia, Hu, Qianqian, Bryant, Annamarie T., Fang, Bin, Remsing Rix, Lily L., Ayaz, Muhammad, Kinose, Fumi, Welsh, Eric A., Eschrich, Steven A., Lawrence, Harshani R., Koomen, John M., Haura, Eric B., Rix, Uwe

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Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells von Ctortecka, Claudia, Palve, Vinayak, Kuenzi, Brent M., Fang, Bin, Sumi, Natalia J., Izumi, Victoria, Novakova, Silvia, Kinose, Fumi, Remsing Rix, Lily L., Haura, Eric B., Koomen, John Matthew, Rix, Uwe

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Turning liabilities into opportunities: Off-target based drug repurposing in cancer von Palve, Vinayak, Liao, Yi, Remsing Rix, Lily L., Rix, Uwe

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A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL von Rix, Uwe, Colinge, Jacques, Blatt, Katharina, Gridling, Manuela, Remsing Rix, Lily L, Parapatics, Katja, Cerny-Reiterer, Sabine, Burkard, Thomas R, Jäger, Ulrich, Melo, Junia V, Bennett, Keiryn L, Valent, Peter, Superti-Furga, Giulio

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The Dynamic Structure of Jadomycin B and the Amino Acid Incorporation Step of Its Biosynthesis von Rix, Uwe, Zheng, Jianting, Remsing Rix, Lily L, Greenwell, Lisa, Yang, Keqian, Rohr, Jürgen

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