Turning liabilities into opportunities: Off-target based drug repurposing in cancer von Palve, Vinayak, Liao, Yi, Remsing Rix, Lily L., Rix, Uwe

Volltext

IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells von Remsing Rix, Lily L, Sumi, Natalia J, Hu, Qianqian, Desai, Bina, Bryant, Annamarie T, Li, Xueli, Welsh, Eric A, Fang, Bin, Kinose, Fumi, Kuenzi, Brent M, Chen, Y Ann, Antonia, Scott J, Lovly, Christine M, Koomen, John M, Haura, Eric B, Marusyk, Andriy, Rix, Uwe

Volltext

Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets von Rix, Uwe, Hantschel, Oliver, Dürnberger, Gerhard, Remsing Rix, Lily L., Planyavsky, Melanie, Fernbach, Nora V., Kaupe, Ines, Bennett, Keiryn L., Valent, Peter, Colinge, Jacques, Köcher, Thomas, Superti-Furga, Giulio

Volltext

Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia von Kuenzi, Brent M., Remsing Rix, Lily L., Kinose, Fumi, Kroeger, Jodi L., Lancet, Jeffrey E., Padron, Eric, Rix, Uwe

Volltext

Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets von Knezevic, Claire E., Wright, Gabriela, Remsing Rix, Lily L., Kim, Woosuk, Kuenzi, Brent M., Luo, Yunting, Watters, January M., Koomen, John M., Haura, Eric B., Monteiro, Alvaro N., Radu, Caius, Lawrence, Harshani R., Rix, Uwe

Volltext

Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach von Fang, Bin, Izumi, Victoria, Rix, Lily L. Remsing, Welsh, Eric, Pike, Ian, Reuther, Gary W., Haura, Eric B., Rix, Uwe, Koomen, John M.

Volltext

Chemoproteomics Reveals Novel Protein and Lipid Kinase Targets of Clinical CDK4/6 Inhibitors in Lung Cancer von Sumi, Natalia J, Kuenzi, Brent M, Knezevic, Claire E, Remsing Rix, Lily L, Rix, Uwe

Volltext

Polypharmacology-based ceritinib repurposing using integrated functional proteomics von Kuenzi, Brent M, Remsing Rix, Lily L, Stewart, Paul A, Fang, Bin, Kinose, Fumi, Bryant, Annamarie T, Boyle, Theresa A, Koomen, John M, Haura, Eric B, Rix, Uwe

Volltext

Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells von Kim, Jae-Young, Welsh, Eric A., Oguz, Umut, Fang, Bin, Bai, Yun, Kinose, Fumi, Bronk, Crystina, Rix, Lily L. Remsing, Beg, Amer A., Rix, Uwe, Eschrich, Steven A., Koomen, John M., Haura, Eric B.

Volltext

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity von Wright, Gabriela, Golubeva, Volha, Remsing Rix, Lily L, Berndt, Norbert, Luo, Yunting, Ward, Grace A, Gray, Jhanelle E, Schonbrunn, Ernst, Lawrence, Harshani R, Monteiro, Alvaro N.A, Rix, Uwe

Volltext

Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2 von Liao, Yi, Remsing Rix, Lily L., Li, Xueli, Fang, Bin, Izumi, Victoria, Welsh, Eric A., Monastyrskyi, Andrii, Haura, Eric B., Koomen, John M., Doebele, Robert C., Rix, Uwe

Volltext

GSK3 Alpha and Beta Are New Functionally Relevant Targets of Tivantinib in Lung Cancer Cells von Remsing Rix, Lily L, Kuenzi, Brent M, Luo, Yunting, Remily-Wood, Elizabeth, Kinose, Fumi, Wright, Gabriela, Li, Jiannong, Koomen, John M, Haura, Eric B, Lawrence, Harshani R, Rix, Uwe

Volltext

Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets von Sumi, Natalia J., Ctortecka, Claudia, Hu, Qianqian, Bryant, Annamarie T., Fang, Bin, Remsing Rix, Lily L., Ayaz, Muhammad, Kinose, Fumi, Welsh, Eric A., Eschrich, Steven A., Lawrence, Harshani R., Koomen, John M., Haura, Eric B., Rix, Uwe

Volltext

Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells von Ctortecka, Claudia, Palve, Vinayak, Kuenzi, Brent M., Fang, Bin, Sumi, Natalia J., Izumi, Victoria, Novakova, Silvia, Kinose, Fumi, Remsing Rix, Lily L., Haura, Eric B., Koomen, John Matthew, Rix, Uwe

Volltext

Dabrafenib inhibits the growth of BRAF‐WT cancers through CDK16 and NEK9 inhibition von Phadke, Manali, Remsing Rix, Lily L., Smalley, Inna, Bryant, Annamarie T., Luo, Yunting, Lawrence, Harshani R., Schaible, Braydon J., Chen, Yian A., Rix, Uwe, Smalley, Keiran S. M.

Volltext

Modification of post-PKS tailoring steps through combinatorial biosynthesis von Rix, Uwe, Fischer, Carsten, Remsing, Lily L, Rohr, Jürgen

Volltext

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model von Sarcar, Bhaswati, Gimbrone, Nicholas T., Wright, Gabriela, Remsing Rix, Lily L., Gordian, Edna R., Rix, Uwe, Chiappori, Alberto A., Reuther, Gary W., Santiago‐Cardona, Pedro G., Muñoz‐Antonia, Teresita, Cress, William Douglas

Volltext

A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL von Rix, Uwe, Colinge, Jacques, Blatt, Katharina, Gridling, Manuela, Remsing Rix, Lily L, Parapatics, Katja, Cerny-Reiterer, Sabine, Burkard, Thomas R, Jäger, Ulrich, Melo, Junia V, Bennett, Keiryn L, Valent, Peter, Superti-Furga, Giulio

Volltext

The Dynamic Structure of Jadomycin B and the Amino Acid Incorporation Step of Its Biosynthesis von Rix, Uwe, Zheng, Jianting, Remsing Rix, Lily L, Greenwell, Lisa, Yang, Keqian, Rohr, Jürgen

Volltext

Structural Basis for the Cytoskeletal Association of Bcr-Abl/c-Abl von Hantschel, Oliver, Wiesner, Silke, Güttler, Thomas, Mackereth, Cameron D., Rix, Lily L. Remsing, Mikes, Zsuzsanna, Dehne, Jana, Görlich, Dirk, Sattler, Michael, Superti-Furga, Giulio

Volltext