Therapies for the Treatment of Advanced/Metastatic Estrogen Receptor-Positive Breast Cancer: Current Situation and Future Directions von Rej, Rohan Kalyan, Roy, Joyeeta, Allu, Srinivasa Rao

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EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development von Rej, Rohan Kalyan, Wang, Changwei, Lu, Jianfeng, Wang, Mi, Petrunak, Elyse, Zawacki, Kaitlin P, McEachern, Donna, Fernandez-Salas, Ester, Yang, Chao-Yie, Wang, Lu, Li, Ruiting, Chinnaswamy, Krishnapriya, Wen, Bo, Sun, Duxin, Stuckey, Jeanne, Zhou, Yunlong, Chen, Jianyong, Tang, Guozhi, Wang, Shaomeng

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Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression von Rej, Rohan Kalyan, Wang, Changwei, Lu, Jianfeng, Wang, Mi, Petrunak, Elyse, Zawacki, Kaitlin P, McEachern, Donna, Yang, Chao-Yie, Wang, Lu, Li, Ruiting, Chinnaswamy, Krishnapriya, Wen, Bo, Sun, Duxin, Stuckey, Jeanne A, Zhou, Yunlong, Chen, Jianyong, Tang, Guozhi, Wang, Shaomeng

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Chemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine von Rej, Rohan Kalyan, Das, Tapas, Hazra, Suman, Nanda, Samik

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Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer Drugs von Rej, Rohan Kalyan, Allu, Srinivasa Rao, Roy, Joyeeta, Acharyya, Ranjan Kumar, Kiran, I N Chaithanya, Addepalli, Yesu, Dhamodharan, V

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Asymmetric synthesis of naturally occurring (−)-seimatopolides A and B von Rej, Rohan Kalyan, Pal, Pratik, Nanda, Samik

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Targeting the Estrogen Receptor for the Treatment of Breast Cancer: Recent Advances and Challenges von Rej, Rohan Kalyan, Acharyya, Ranjan Kumar, Rae, James Michael, Wang, Shaomeng

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Chemoenzymatic Asymmetric Total Synthesis of Nonanolide (Z)-Cytospolides D, E and Their Stereoisomers von Rej, Rohan Kalyan, Nanda, Samik

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Exploration of Ring Rearrangement Metathesis Reaction: A General and Flexible Approach for the Rapid Construction [5,n]‑Fused Bicyclic Systems en Route to Linear Triquinanes von Acharyya, Ranjan Kumar, Rej, Rohan Kalyan, Nanda, Samik

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Asymmetric synthesis of cytospolides C and D through successful exploration of stereoselective Julia–Kocienski olefination and Suzuki reaction followed by macrolactonization von Rej, Rohan Kalyan, Kumar, Rajan, Nanda, Samik

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Asymmetric synthesis of naturally occurring nonenolide xyolide through cross metathesis and macrolactonization reaction von Rej, Rohan Kalyan, Jana, Anuvab, Nanda, Samik

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Asymmetric synthesis of dihydroartemisinic acid through intramolecular Stetter reaction von Rej, Rohan Kalyan, Acharyya, Ranjan Kumar, Nanda, Samik

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Asymmetric total synthesis of (−)-mangiferaelactone by using an appropriately substituted thiophene as a masked synthon for C-alkyl glycoside von Kumar, Rajan, Rej, Rohan Kalyan, Nanda, Samik

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Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9 von Wang, Changwei, Wang, Mi, Wang, Yu, Rej, Rohan Kalyan, Aguilar, Angelo, Xu, Tianfeng, Bai, Longchuan, Tošović, Jelena, McEachern, Donna, Li, Qiuxia, Sarkari, Farzad, Wen, Bo, Sun, Duxin, Wang, Shaomeng

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Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity von Chen, Zhixiang, Hu, Biao, Rej, Rohan Kalyan, Wu, Dimin, Acharyya, Ranjan Kumar, Wang, Mingliang, Xu, Tianfeng, Lu, Jianfeng, Metwally, Hoda, Wang, Yu, McEachern, Donna, Bai, Longchuan, Gersch, Christina L., Wang, Meilin, Zhang, Wenjing, Li, Qiuxia, Wen, Bo, Sun, Duxin, Rae, James M., Wang, Shaomeng

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Discovery of Pyrrolo[2,3‑c]pyridines as Potent and Reversible LSD1 Inhibitors von Zheng, Canhui, Rej, Rohan Kalyan, Wang, Mi, Huang, Liyue, Fernandez-Salas, Ester, Yang, Chao-Yie, Wang, Shaomeng

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Discovery of Pyrrolo2,3-cpyridines as Potent and Reversible LSD1 Inhibitors von Zheng, Canhui, Rej, Rohan Kalyan, Wang, Mi, Huang, Liyue, Fernandez-Salas, Ester, Yang, Chao-Yie, Wang, Shaomeng

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Discovery of ERD-12310A as an Exceptionally Potent and Orally Efficacious PROTAC Degrader of Estrogen Receptor α (ERα) von Rej, Rohan Kalyan, Hu, Biao, Chen, Zhixiang, Acharyya, Ranjan Kumar, Wu, Dimin, Metwally, Hoda, McEachern, Donna, Wang, Yu, Jiang, Wei, Bai, Longchuan, Nishimura, Leticia S, Gersch, Christina L., Wang, Meilin, Wen, Bo, Sun, Duxin, Carlson, Kathryn, Katzenellenbogen, John A., Xu, Guozhang, Zhang, Weihong, Wu, Wenxue, Priestley, E. Scott, Sui, Zhihua, Rae, James M., Wang, Shaomeng

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Discovery of ERD-1233 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader for the Treatment of ER+ Human Breast Cancer von Acharyya, Ranjan Kumar, Rej, Rohan Kalyan, Hu, Biao, Chen, Zhixiang, Wu, Dimin, Lu, Jianfeng, Metwally, Hoda, McEachern, Donna, Wang, Yu, Jiang, Wei, Bai, Longchuan, Tošović, Jelena, Gersch, Christina L., Xu, Guozhang, Zhang, Weihong, Wu, WenXue, Priestley, E. Scott, Sui, Zhihua, Sarkari, Farzad, Wen, Bo, Sun, Duxin, Rae, James M., Wang, Shaomeng

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Abstract 1036: Discovery of a highly potent, efficacious and orally active small-molecule inhibitor of embryonic ectoderm development (EED) von Wang, Changwei, Rej, Rohan Kalyan, Lu, Jianfeng, Wang, Mi, Harvey, Kaitlin P., Yang, Chao-Yie, Fernandez-Salas, Ester, Stuckey, Jeanne, Petrunak, Elyse, Foster, Caroline, Zhou, Yunlong, Zhou, Rubin, Tang, Guozhi, Chen, Jianyong, Wang, Shaomeng

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