cGAS surveillance of micronuclei links genome instability to innate immunity von Mackenzie, Karen J., Carroll, Paula, Martin, Carol-Anne, Murina, Olga, Fluteau, Adeline, Simpson, Daniel J., Olova, Nelly, Sutcliffe, Hannah, Rainger, Jacqueline K., Leitch, Andrea, Osborn, Ruby T., Wheeler, Ann P., Nowotny, Marcin, Gilbert, Nick, Chandra, Tamir, Reijns, Martin A. M., Jackson, Andrew P.

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Lagging-strand replication shapes the mutational landscape of the genome von Reijns, Martin A. M., Kemp, Harriet, Ding, James, Marion de Procé, Sophie, Jackson, Andrew P., Taylor, Martin S.

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CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions von Zimmermann, Michal, Murina, Olga, Reijns, Martin A. M., Agathanggelou, Angelo, Challis, Rachel, Tarnauskaitė, Žygimantė, Muir, Morwenna, Fluteau, Adeline, Aregger, Michael, McEwan, Andrea, Yuan, Wei, Clarke, Matthew, Lambros, Maryou B., Paneesha, Shankara, Moss, Paul, Chandrashekhar, Megha, Angers, Stephane, Moffat, Jason, Brunton, Valerie G., Hart, Traver, de Bono, Johann, Stankovic, Tatjana, Jackson, Andrew P., Durocher, Daniel

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Ribonucleotides Misincorporated into DNA Act as Strand-Discrimination Signals in Eukaryotic Mismatch Repair von Ghodgaonkar, Medini Manohar, Lazzaro, Federico, Olivera-Pimentel, Maite, Artola-Borán, Mariela, Cejka, Petr, Reijns, Martin A., Jackson, Andrew P., Plevani, Paolo, Muzi-Falconi, Marco, Jiricny, Josef

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Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model von Moss, Chloe F, Dalla Rosa, Ilaria, Hunt, Lilian E, Yasukawa, Takehiro, Young, Robert, Jones, Aleck W E, Reddy, Kaalak, Desai, Radha, Virtue, Sam, Elgar, Greg, Voshol, Peter, Taylor, Martin S, Holt, Ian J, Reijns, Martin A M, Spinazzola, Antonella

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Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq von Ding, James, Taylor, Martin S, Jackson, Andrew P, Reijns, Martin A M

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role for Q/N-rich aggregation-prone regions in P-body localization von Reijns, Martin A.M, Alexander, Ross D, Spiller, Michael P, Beggs, Jean D

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Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions von Heyn, Patricia, Logan, Clare V., Fluteau, Adeline, Challis, Rachel C., Auchynnikava, Tatsiana, Martin, Carol-Anne, Marsh, Joseph A., Taglini, Francesca, Kilanowski, Fiona, Parry, David A., Cormier-Daire, Valerie, Fong, Chin-To, Gibson, Kate, Hwa, Vivian, Ibáñez, Lourdes, Robertson, Stephen P., Sebastiani, Giorgia, Rappsilber, Juri, Allshire, Robin C., Reijns, Martin A. M., Dauber, Andrew, Sproul, Duncan, Jackson, Andrew P.

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PCNA directs type 2 RNase H activity on DNA replication and repair substrates von Bubeck, Doryen, Reijns, Martin A M, Graham, Stephen C, Astell, Katy R, Jones, E Yvonne, Jackson, Andrew P

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Human and Mouse Mutations in WDR35 Cause Short-Rib Polydactyly Syndromes Due to Abnormal Ciliogenesis von Mill, Pleasantine, Lockhart, Paul J., Fitzpatrick, Elizabeth, Mountford, Hayley S., Hall, Emma A., Reijns, Martin A.M., Keighren, Margaret, Bahlo, Melanie, Bromhead, Catherine J., Budd, Peter, Aftimos, Salim, Delatycki, Martin B., Savarirayan, Ravi, Jackson, Ian J., Amor, David J.

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Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis von Beyer, Ulrike, Brand, Frank, Martens, Helge, Weder, Julia, Christians, Arne, Elyan, Natalie, Hentschel, Bettina, Westphal, Manfred, Schackert, Gabriele, Pietsch, Torsten, Hong, Bujung, Krauss, Joachim K., Samii, Amir, Raab, Peter, Das, Anibh, Dumitru, Claudia A., Sandalcioglu, I. Erol, Hakenberg, Oliver W., Erbersdobler, Andreas, Lehmann, Ulrich, Reifenberger, Guido, Weller, Michael, Reijns, Martin A. M., Preller, Matthias, Wiese, Bettina, Hartmann, Christian, Weber, Ruthild G.

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Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response von Mackenzie, Karen J, Carroll, Paula, Lettice, Laura, Tarnauskaitė, Žygimantė, Reddy, Kaalak, Dix, Flora, Revuelta, Ailsa, Abbondati, Erika, Rigby, Rachel E, Rabe, Björn, Kilanowski, Fiona, Grimes, Graeme, Fluteau, Adeline, Devenney, Paul S, Hill, Robert E, Reijns, Martin AM, Jackson, Andrew P

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RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition von Benitez‐Guijarro, Maria, Lopez‐Ruiz, Cesar, Tarnauskaitė, Žygimantė, Murina, Olga, Mian Mohammad, Mahwish, Williams, Thomas C, Fluteau, Adeline, Sanchez, Laura, Vilar‐Astasio, Raquel, Garcia‐Canadas, Marta, Cano, David, Kempen, Marie‐Jeanne HC, Sanchez‐Pozo, Antonio, Heras, Sara R, Jackson, Andrew P, Reijns, Martin AM, Garcia‐Perez, Jose L

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Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development von Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.

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In silico protein interaction screening uncovers DONSON's role in replication initiation von Lim, Yang, Tamayo-Orrego, Lukas, Schmid, Ernst, Tarnauskaite, Zygimante, Kochenova, Olga V, Gruar, Rhian, Muramatsu, Sachiko, Lynch, Luke, Schlie, Aitana Verdu, Carroll, Paula L, Chistol, Gheorghe, Reijns, Martin A M, Kanemaki, Masato T, Jackson, Andrew P, Walter, Johannes C

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DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes von Giordano, Anna Maria Sole, Luciani, Marco, Gatto, Francesca, Abou Alezz, Monah, Beghè, Chiara, Della Volpe, Lucrezia, Migliara, Alessandro, Valsoni, Sara, Genua, Marco, Dzieciatkowska, Monika, Frati, Giacomo, Tahraoui-Bories, Julie, Giliani, Silvia Clara, Orcesi, Simona, Fazzi, Elisa, Ostuni, Renato, D'Alessandro, Angelo, Di Micco, Raffaella, Merelli, Ivan, Lombardo, Angelo, Reijns, Martin A M, Gromak, Natalia, Gritti, Angela, Kajaste-Rudnitski, Anna

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Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes von Spiller, Michael P, Reijns, Martin A.M, Beggs, Jean D

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Defective removal of ribonucleotides from DNA promotes systemic autoimmunity von Günther, Claudia, Kind, Barbara, Reijns, Martin A M, Berndt, Nicole, Martinez-Bueno, Manuel, Wolf, Christine, Tüngler, Victoria, Chara, Osvaldo, Lee, Young Ae, Hübner, Norbert, Bicknell, Louise, Blum, Sophia, Krug, Claudia, Schmidt, Franziska, Kretschmer, Stefanie, Koss, Sarah, Astell, Katy R, Ramantani, Georgia, Bauerfeind, Anja, Morris, David L, Cunninghame Graham, Deborah S, Bubeck, Doryen, Leitch, Andrea, Ralston, Stuart H, Blackburn, Elizabeth A, Gahr, Manfred, Witte, Torsten, Vyse, Timothy J, Melchers, Inga, Mangold, Elisabeth, Nöthen, Markus M, Aringer, Martin, Kuhn, Annegret, Lüthke, Kirsten, Unger, Leonore, Bley, Annette, Lorenzi, Alice, Isaacs, John D, Alexopoulou, Dimitra, Conrad, Karsten, Dahl, Andreas, Roers, Axel, Alarcon-Riquelme, Marta E, Jackson, Andrew P, Lee-Kirsch, Min Ae

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RNA:DNA hybrids are a novel molecular pattern sensed by TLR9 von Rigby, Rachel E, Webb, Lauren M, Mackenzie, Karen J, Li, Yue, Leitch, Andrea, Reijns, Martin A M, Lundie, Rachel J, Revuelta, Ailsa, Davidson, Donald J, Diebold, Sandra, Modis, Yorgo, MacDonald, Andrew S, Jackson, Andrew P

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Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin von Hiller, Björn, Hoppe, Anja, Haase, Christa, Hiller, Christina, Schubert, Nadja, Müller, Werner, Reijns, Martin A M, Jackson, Andrew P, Kunkel, Thomas A, Wenzel, Jörg, Behrendt, Rayk, Roers, Axel

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