1493 Developing a 3D multicellular model to investigate stromal and immune interactions in colorectal cancer tumour microenvironment von Reidy, Eileen, Leonard, Niamh, Pandit, Abhay, Ryan, Aideen E

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967 Inflammatory tumour microenvironment in CRC alters macrophage function through mesenchymal stromal cell PD-1/PD-L1 signalling von Leonard, Niamh, Corry, Shania, Treacy, Oliver, Reidy, Eileen, Redmond, Keara, Egan, Hannah, Sheehan, Margaret, Canney, Aoife, Hogan, Aisling, Loessner, Daniela, Egan, Laurence, Hynes, Sean, Ritter, Thomas, Dunne, Philip, Ryan, Aideen E

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Development of a state-of-the-art multicellular model of the three dimensional (3D) colorectal tumour microenvironment von Reidy, Eileen

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A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance von Reidy, Eileen, Leonard, Niamh A., Treacy, Oliver, Ryan, Aideen E.

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Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment von Egan, Hannah, Treacy, Oliver, Lynch, Kevin, Leonard, Niamh A., O’Malley, Grace, Reidy, Eileen, O’Neill, Aoise, Corry, Shania M., De Veirman, Kim, Vanderkerken, Karin, Egan, Laurence J., Ritter, Thomas, Hogan, Aisling M., Redmond, Keara, Peng, Li, Che, Jenny, Gatlin, Wayne, Jayaraman, Pushpa, Sheehan, Margaret, Canney, Aoife, Hynes, Sean O., Kerr, Emma M., Dunne, Philip D., O’Dwyer, Michael E., Ryan, Aideen E.

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Auranofin loaded silk fibroin nanoparticles for colorectal cancer treatment von Pérez-Lloret, Marta, Reidy, Eileen, Lozano-Pérez, Antonio Abel, Marchal, Juan A., Lens, Piet N. L., Ryan, Aideen E., Erxleben, Andrea

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Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer von Leonard, Niamh A., Reidy, Eileen, Thompson, Kerry, McDermott, Emma, Peerani, Eleonora, Tomas Bort, Elena, Balkwill, Frances R., Loessner, Daniela, Ryan, Aideen E.

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Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling von Leonard, Niamh A., Corry, Shania M., Reidy, Eileen, Egan, Hannah, O’Malley, Grace, Thompson, Kerry, McDermott, Emma, O’Neill, Aoise, Zakaria, Norashikin, Egan, Laurence J., Ritter, Thomas, Loessner, Daniela, Redmond, Keara, Sheehan, Margaret, Canney, Aoife, Hogan, Aisling M., Hynes, Sean O., Treacy, Oliver, Dunne, Philip D., Ryan, Aideen E.

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Cancer immunophenotyping by seven‐colour multispectral imaging without tyramide signal amplification von Ijsselsteijn, Marieke E, Brouwer, Thomas P, Abdulrahman, Ziena, Reidy, Eileen, Ramalheiro, Ana, Heeren, A Marijne, Vahrmeijer, Alexander, Jordanova, Ekaterina S, de Miranda, Noel FCC

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Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients von Yaeger, Rona, Cercek, Andrea, O'Reilly, Eileen M, Reidy, Diane L, Kemeny, Nancy, Wolinsky, Tamar, Capanu, Marinela, Gollub, Marc J, Rosen, Neal, Berger, Michael F, Lacouture, Mario E, Vakiani, Efsevia, Saltz, Leonard B

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PD-1 Blockade in Advanced Adrenocortical Carcinoma von Raj, Nitya, Zheng, Youyun, Kelly, Virginia, Katz, Seth S., Chou, Joanne, Do, Richard K. G., Capanu, Marinela, Zamarin, Dmitriy, Saltz, Leonard B., Ariyan, Charlotte E., Untch, Brian R., O'Reilly, Eileen M., Gopalan, Anuradha, Berger, Michael F., Olino, Kelly, Segal, Neil H., Reidy-Lagunes, Diane L.

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Well-Differentiated Neuroendocrine Tumors with a Morphologically Apparent High-Grade Component: A Pathway Distinct from Poorly Differentiated Neuroendocrine Carcinomas von Tang, Laura H, Untch, Brian R, Reidy, Diane L, O'Reilly, Eileen, Dhall, Deepti, Jih, Lily, Basturk, Olca, Allen, Peter J, Klimstra, David S

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Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer von Latham, Alicia, Srinivasan, Preethi, Kemel, Yelena, Shia, Jinru, Bandlamudi, Chaitanya, Mandelker, Diana, Middha, Sumit, Hechtman, Jaclyn, Zehir, Ahmet, Dubard-Gault, Marianne, Tran, Christina, Stewart, Carolyn, Sheehan, Margaret, Penson, Alexander, DeLair, Deborah, Yaeger, Rona, Vijai, Joseph, Mukherjee, Semanti, Galle, Jesse, Dickson, Mark A, Janjigian, Yelena, O'Reilly, Eileen M, Segal, Neil, Saltz, Leonard B, Reidy-Lagunes, Diane, Varghese, Anna M, Bajorin, Dean, Carlo, Maria I, Cadoo, Karen, Walsh, Michael F, Weiser, Martin, Aguilar, Julio Garcia, Klimstra, David S, Diaz, Jr, Luis A, Baselga, Jose, Zhang, Liying, Ladanyi, Marc, Hyman, David M, Solit, David B, Robson, Mark E, Taylor, Barry S, Offit, Kenneth, Berger, Michael F, Stadler, Zsofia K

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A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma von Abou-Alfa, Ghassan K, Capanu, Marinela, O’Reilly, Eileen M, Ma, Jennifer, Chou, Joanne F, Gansukh, Bolorsukh, Shia, Jinru, Kalin, Marcia, Katz, Seth, Abad, Leslie, Reidy-Lagunes, Diane L, Kelsen, David P, Chen, Helen X, Saltz, Leonard B

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Commentary on “Validity of General Movement Assessment Based on Clinical and Home Videos” von Ricci, Eileen, Reidy, Joanna

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Identification of germline genetic mutations in patients with pancreatic cancer von Salo‐Mullen, Erin E., O'Reilly, Eileen M., Kelsen, David P., Ashraf, Asad M., Lowery, Maeve A., Yu, Kenneth H., Reidy, Diane L., Epstein, Andrew S., Lincoln, Anne, Saldia, Amethyst, Jacobs, Lauren M., Rau‐Murthy, Rohini, Zhang, Liying, Kurtz, Robert C., Saltz, Leonard, Offit, Kenneth, Robson, Mark E., Stadler, Zsofia K.

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A Single-Arm, Nonrandomized Phase II Trial of Neoadjuvant Gemcitabine and Oxaliplatin in Patients With Resectable Pancreas Adenocarcinoma von OʼReilly, Eileen M, Perelshteyn, Anna, Jarnagin, William R, Schattner, Mark, Gerdes, Hans, Capanu, Marinela, Tang, Laura H, LaValle, Joseph, Winston, Corinne, DeMatteo, Ronald P, DʼAngelica, Michael, Kurtz, Robert C, Abou-Alfa, Ghassan K, Klimstra, David S, Lowery, Maeve A, Brennan, Murray F, Coit, Daniel G, Reidy, Diane L, Kingham, T Peter, Allen, Peter J

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A randomized controlled trial of a cardiopulmonary resuscitation video in advance care planning for progressive pancreas and hepatobiliary cancer patients von Epstein, Andrew S, Volandes, Angelo E, Chen, Ling Y, Gary, Kristen A, Li, Yuelin, Agre, Patricia, Levin, Tomer T, Reidy, Diane L, Meng, Raymond D, Segal, Neil H, Yu, Kenneth H, Abou-Alfa, Ghassan K, Janjigian, Yelena Y, Kelsen, David P, O'Reilly, Eileen M

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Neoplasia risk in patients with Lynch syndrome treated with immune checkpoint blockade von Harrold, Emily C., Foote, Michael B., Rousseau, Benoit, Walch, Henry, Kemel, Yelena, Richards, Allison L., Keane, Fergus, Cercek, Andrea, Yaeger, Rona, Rathkopf, Dana, Segal, Neil H., Patel, Zalak, Maio, Anna, Borio, Matilde, O’Reilly, Eileen M., Reidy, Diane, Desai, Avni, Janjigian, Yelena Y., Murciano-Goroff, Yonina R., Carlo, Maria I., Latham, Alicia, Liu, Ying L., Walsh, Michael F., Ilson, David, Rosenberg, Jonathan E., Markowitz, Arnold J., Weiser, Martin R., Rossi, Anthony M., Vanderbilt, Chad, Mandelker, Diana, Bandlamudi, Chaitanya, Offit, Kenneth, Berger, Michael F., Solit, David B., Saltz, Leonard, Shia, Jinru, Diaz, Luis A., Stadler, Zsofia K.

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Chemotherapy and intensity-modulated radiation therapy for locally advanced pancreatic cancer achieves a high rate of R0 resection von Huguet, Florence, Hajj, Carla, Winston, Corrine B, Shi, Weiji, Zhang, Zhigang, Wu, Abraham J, O'Reilly, Eileen M, Reidy, Diane L, Allen, Peter, Goodman, Karyn A

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