CO4 How Can the Long-Term Benefits and Harms of Screening Be Transparently Quantified and Contrasted for Informed Decision-Making? Colorectal Cancer Screening for Persons at Famili... von Sroczynski, G., Hallsson, L.R., Mühlberger, N., Jahn, B., Hoffmann, S., Rehms, R., Lindörfer, D., Crispin, A., Mansmann, U., Siebert, U.

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EE131 Health-Economic Evaluation of Early Screening for Individuals Younger Than Age 50 with Familial Colorectal Cancer Risk Based on a Decision Analysis within the Farkor Study von Sroczynski, G, Hallsson, LR, Mühlberger, N, Jahn, B, Hoffmann, S, Rehms, R, Lindörfer, D, Crispin, A, Mansmann, U, Siebert, U

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Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis von Tidswell, Mark, Tillis, William, LaRosa, Steven P, Lynn, Melvyn, Wittek, Alec E, Kao, Richard, Wheeler, Janice, Gogate, Jagadish, Opal, Steven M

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Heil Neujahr. Trübe Aussichten

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Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria von Pejaver, Vikas, Byrne, Alicia B., Feng, Bing-Jian, Pagel, Kymberleigh A., Mooney, Sean D., Karchin, Rachel, O’Donnell-Luria, Anne, Harrison, Steven M., Tavtigian, Sean V., Greenblatt, Marc S., Biesecker, Leslie G., Radivojac, Predrag, Brenner, Steven E., Biesecker, Leslie G., Harrison, Steven M., Tayoun, Ahmad A., Berg, Jonathan S., Brenner, Steven E., Cutting, Garry R., Ellard, Sian, Greenblatt, Marc S., Kang, Peter, Karbassi, Izabela, Karchin, Rachel, Mester, Jessica, O’Donnell-Luria, Anne, Pesaran, Tina, Plon, Sharon E., Rehm, Heidi L., Strande, Natasha T., Tavtigian, Sean V., Topper, Scott

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Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 von Afshin, Ashkan, Sur, Patrick John, Fay, Kairsten A., Ferrara, Giannina, Salama, Joseph S, Mullany, Erin C, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abebe, Zegeye, Aggarwal, Anju, Agrawal, Sutapa, Akinyemiju, Tomi, Bacha, Umar, Bachman, Victoria F, Badali, Hamid, Badawi, Alaa, Bensenor, Isabela M, Biryukov, Stan H, Cahill, Leah E, Dandona, Lalit, Dandona, Rakhi, Dang, Anh Kim, Degefa, Meaza Girma, El Sayed Zaki, Maysaa, Esteghamati, Alireza, Esteghamati, Sadaf, Fanzo, Jessica, Farvid, Maryam S, Farzadfar, Farshad, Feigin, Valery L., Fernandes, Joao C, Flor, Luisa Sorio, Foigt, Nataliya A., Forouzanfar, Mohammad H, Ganji, Morsaleh, Gillum, Richard F, Goulart, Alessandra C, Grosso, Giuseppe, Guessous, Idris, Hamidi, Samer, Harikrishnan, Sivadasanpillai, Hassen, Hamid Yimam, Hay, Simon I., Hoang, Chi Linh, Ikeda, Nayu, Jackson, Maria D., James, Spencer L., Johansson, Lars, Kasaeian, Amir, Khader, Yousef Saleh, Khalil, Ibrahim A., Khang, Young-Ho, Kimokoti, Ruth W, Kokubo, Yoshihiro, Kumar, G Anil, Lopez, Alan D, Lotufo, Paulo A., Lozano, Rafael, Meier, Toni, Melaku, Yohannes A, Mensink, Gert B.M., Micha, Renata, Miller, Ted R, Mirarefin, Mojde, Mohan, Viswanathan, Mokdad, Ali H, Mozaffarian, Dariush, Nagel, Gabriele, Naghavi, Mohsen, Nixon, Molly R, Poustchi, Hossein, Qorbani, Mostafa, Rai, Rajesh Kumar, Razo-García, Christian, Rehm, Colin D, Roshandel, Gholamreza, Sanabria, Juan, Sánchez-Pimienta, Tania G, Sartorius, Benn, Schmidhuber, Josef, Schutte, Aletta Elisabeth, Sepanlou, Sadaf G., Springmann, Marco, Szponar, Lucjan, Thorne-Lyman, Andrew L, Tran, Bach Xuan, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A, Vaezghasemi, Masoud, Vasankari, Tommi Juhani, Vollset, Stein Emil, Vos, Theo, Vu, Giang Thu, Weiderpass, Elisabete, Willett, Walter C, Wu, Jason H, Yonemoto, Naohiro, Yu, Chuanhua, Murray, Christopher J L

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Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework von Brnich, Sarah E, Abou Tayoun, Ahmad N, Couch, Fergus J, Cutting, Garry R, Greenblatt, Marc S, Heinen, Christopher D, Kanavy, Dona M, Luo, Xi, McNulty, Shannon M, Starita, Lea M, Tavtigian, Sean V, Wright, Matt W, Harrison, Steven M, Biesecker, Leslie G, Berg, Jonathan S

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The landscape of reported VUS in multi-gene panel and genomic testing: Time for a change von Rehm, Heidi L., Alaimo, Joseph T., Aradhya, Swaroop, Bayrak-Toydemir, Pinar, Best, Hunter, Brandon, Rhonda, Buchan, Jillian G., Chao, Elizabeth C., Chen, Elaine, Clifford, Jacob, Cohen, Ana S.A., Conlin, Laura K., Das, Soma, Davis, Kyle W., del Gaudio, Daniela, Del Viso, Florencia, DiVincenzo, Christina, Eisenberg, Marcia, Guidugli, Lucia, Hammer, Monia B., Harrison, Steven M., Hatchell, Kathryn E., Dyer, Lindsay Havens, Hoang, Lily U., Holt, James M., Jobanputra, Vaidehi, Karbassi, Izabela D., Kearney, Hutton M., Kelly, Melissa A., Kelly, Jacob M., Kluge, Michelle L., Komala, Timothy, Kruszka, Paul, Lau, Lynette, Lebo, Matthew S., Marshall, Christian R., McKnight, Dianalee, McWalter, Kirsty, Meng, Yan, Nagan, Narasimhan, Neckelmann, Christian S., Neerman, Nir, Niu, Zhiyv, Paolillo, Vitoria K., Paolucci, Sarah A., Perry, Denise, Pesaran, Tina, Radtke, Kelly, Rasmussen, Kristen J., Retterer, Kyle, Saunders, Carol J., Spiteri, Elizabeth, Stanley, Christine, Szuto, Anna, Taft, Ryan J., Thiffault, Isabelle, Thomas, Brittany C., Thomas-Wilson, Amanda, Thorpe, Erin, Tidwell, Timothy J., Towne, Meghan C., Zouk, Hana, Marshall, Christian, Meng, Linyan, Jobanputra, Vaidehi, Taft, Ryan, Ashley, Euan, Nakouzi, Ghunwa, Shen, Wei, Kingsmore, Stephen, Rehm, Heidi

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Long-term benefits and harms of early colorectal cancer screening in German individuals with familial cancer risk von Sroczynski, Gaby, Hallsson, Lára R, Mühlberger, Nikolai, Jahn, Beate, Rehms, Raphael, Hoffmann, Sabine, Crispin, Alexander, Lindoerfer, Doris, Mansmann, Ulrich, Siebert, Uwe

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Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup von Walker, Logan C., Hoya, Miguel de la, Wiggins, George A.R., Lindy, Amanda, Vincent, Lisa M., Parsons, Michael T., Canson, Daffodil M., Bis-Brewer, Dana, Cass, Ashley, Tchourbanov, Alexander, Zimmermann, Heather, Byrne, Alicia B., Pesaran, Tina, Karam, Rachid, Harrison, Steven M., Spurdle, Amanda B., Biesecker, Leslie G., Harrison, Steven M., Tayoun, Ahmad A., Berg, Jonathan S., Brenner, Steven E., Cutting, Garry R., Ellard, Sian, Greenblatt, Marc S., Kang, Peter, Karbassi, Izabela, Karchin, Rachel, Mester, Jessica, O’Donnell-Luria, Anne, Pesaran, Tina, Plon, Sharon E., Rehm, Heidi L., Strande, Natasha T., Tavtigian, Sean V., Topper, Scott

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Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism von BÜLLER, Harry R, DECOUSUS, Hervé, MINGGAO SHI, VERHAMME, Peter, WELLS, Phil, GROSSO, Michael A, MERCURI, Michele, MIDDELDORP, Saskia, PRINS, Martin H, RASKOB, Gary E, SCHELLONG, Sebastian M, SCHWOCHO, Lee, SEGERS, Annelise

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Incident type 2 diabetes attributable to suboptimal diet in 184 countries von O’Hearn, Meghan, Lara-Castor, Laura, Cudhea, Frederick, Miller, Victoria, Reedy, Julia, Shi, Peilin, Zhang, Jianyi, Wong, John B., Economos, Christina D., Micha, Renata, Mozaffarian, Dariush

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Addressing the burden of mental, neurological, and substance use disorders: key messages from Disease Control Priorities , 3rd edition von Patel, Vikram, Prof, Chisholm, Dan, PhD, Parikh, Rachana, MPH, Charlson, Fiona J, MPH, Degenhardt, Louisa, Prof, Dua, Tarun, MD, Ferrari, Alize J, PhD, Hyman, Steve, Prof, Laxminarayan, Ramanan, Prof, Levin, Carol, PhD, Lund, Crick, Prof, Medina Mora, María Elena, Prof, Petersen, Inge, Prof, Scott, James, PhD, Shidhaye, Rahul, MD, Vijayakumar, Lakshmi, PhD, Thornicroft, Graham, Prof, Whiteford, Harvey, Prof

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Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial von Qian, Edward T, Casey, Jonathan D, Wright, Adam, Wang, Li, Shotwell, Matthew S, Siemann, Justin K, Dear, Mary Lynn, Stollings, Joanna L, Lloyd, Brad D, Marvi, Tanya K, Seitz, Kevin P, Nelson, George E, Wright, Patty W, Siew, Edward D, Dennis, Bradley M, Wrenn, Jesse O, Andereck, Jonathan W, Han, Jin H, Self, Wesley H, Semler, Matthew W, Rice, Todd W

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Vaccination Ameliorates Cellular Inflammatory Responses in SARS-CoV-2 Breakthrough Infections von Huapaya, Julio A, Higgins, Jeanette, Kanth, Shreya, Demirkale, Cumhur Y, Gairhe, Salina, Aboye, Etsubdink A, Regenold, David, Sahagun, Seynt Jiro, Pastor, Gloria, Swaim, Doris, Dewar, Robin, Rehman, Tauseef, Highbarger, Helene C, Lallemand, Perrine, Laverdure, Sylvain, Adelsberger, Joseph, Rupert, Adam, Li, Willy, Krack, Janell, Teferi, Gebeyehu, Kuruppu, Janaki, Strich, Jeffrey R, Davey, Richard, Childs, Richard, Chertow, Daniel, Kovacs, Joseph A, Barnett, Christopher, Torabi-Parizi, Parizad, Suffredini, Anthony F

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Colorectal Cancer Screening for Persons With a Positive Family History von Crispin, Alexander, Rehms, Raphael, Hoffmann, Sabine, Lindoerfer, Doris, Hallsson, Lára R, Jahn, Beate, Mühlberger, Nikolai, Sroczynski, Gaby, Siebert, Uwe, Mansmann, Ulrich

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Frequency of genomic secondary findings among 21,915 eMERGE network participants von Gordon, Adam S, Zouk Hana, Venner, Eric, Eng, Christine M, Funke, Birgit H, Amendola, Laura M, Carrell, David S, Chisholm, Rex L, Chung, Wendy K, Denny, Joshua C, Fedotov, Alexander, Hakonarson Hakon, Kullo, Iftikhar J, Larson, Eric B, Leduc, Magalie S, Leppig, Kathleen A, Lennon, Niall J, Linder, Jodell E, Muzny, Donna M, Prows, Cynthia A, Rasmussen-Torvik, Laura J, Rasouly Hila Milo, Roden, Dan M, Rosenthal, Elisabeth A, Smith, Maureen E, Stanaway, Ian B, Van Driest Sara L, Walker, Kimberly, Wiesner, Georgia L, Williams, Marc S, Witkowski Leora, Crosslin David R, Gibbs, Richard A, Rehm, Heidi L, Jarvik, Gail P

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Advancing Genetic Testing in Kidney Diseases: Report From a National Kidney Foundation Working Group von Franceschini, Nora, Feldman, David L., Berg, Jonathan S., Besse, Whitney, Chang, Alexander R., Dahl, Neera K., Gbadegesin, Rasheed, Pollak, Martin R., Rasouly, Hila Milo, Smith, Richard J.H., Winkler, Cheryl A., Gharavi, Ali G., Ars, Elisabet, Reza Bekheirnia, Mir, Bier, Louise, Bleyer, Anthony J., Fuller, Lindsey J., Halbritter, Jan, Harris, Peter C., Kiryluk, Krzysztof, Knoers, Nine V.A.M., Kopp, Jeffrey B., Kramer, Holly, Lagas, Sharon S., Lieske, John C., Lu, Weining, Mannon, Roslyn B., Markowitz, Glen, Moe, Orson W., Nadkarni, Girish N., Nast, Cynthia C., Parekh, Rulan S., Pei, York, Reed, Katie, Rehm, Heidi L., Richards, Denay J., Roberts, Mary-Beth, Sabatello, Maya, Salant, David J., Sampson, Matthew G., Sanna-Cherchi, Simone, Santoriello, Dominick, Sedor, John R., Sneddon, Tam P., Watnick, Terry, Wilfond, Benjamin S., Williams, Winfred W., Wong, Craig S.

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Colorectal Cancer Screening for Persons With a Positive Family History—Evaluation of the FARKOR Program for the Secondary Prevention of Colorectal Cancer in Persons Aged 25 to 50 von Crispin, Alexander, Rehms, Raphael, Hoffmann, Sabine, Lindoerfer, Doris, Hallsson, Lára R, Jahn, Beate, Mühlberger, Nikolai, Sroczynski, Gaby, Siebert, Uwe, Mansmann, Ulrich

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Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung von Koutsokera, Angela, Claustre, Johanna, Kessler, Romain, Benden, Christian, Marsland, Benjamin J., Berré, J., Brimioulle, S., Preiser, T.J.C., Van Obberghe, L., Giroux, M., Angelescu, D., Hacini, R., Casez-Brasseur, M., Dessertaine, G., Marino, M.R., Oummahan, B., Protar, D., Boignard, A., Briault, A., Claustre, J., Chanoine, S., Dubuc, M., Wion, N., Jegaden, O., Tronc, F., Mornex, J.-F., Turquier, S., Gamondes, D., Chalabresse, L., Dubois, C., Achouh, P., Guillemain, R., Pezella, V., Doddoli, C., Trousse, D., Dufeu, N., Dutau, H., Gomez, C., Laroumagne, S., Mouton, G., Baron, O., Danger, R., Loy, J., Morisset, M., Pares, S., Fabre, D., Mercier, O., Mussot, S., Cerrina, J., Ghigna, S.M., Hervén, Ph, Le Roy Ladurie, F., Thomas de Montpreville, V., Lamrani, L., Dauriat, G., Métivier, A.-C., Thabut, G., Lhuillier, E., Helms, O., Hentz, J., Roche, A., Ohlmann-Caillard, S., Kessler, L., Schuller, A., Bennedif, K., Stauder, J., Puyo, P., Sage, E., Cerf, C., Si Larbi, A.-G., Leguen, M., De Miranda, S., Gonin, F., Grenet, D., Hamid, A.M., Neveu, H., Parquin, F., Picard, C., Stern, M., Cahen, P., Gravisse, J., Mellot, F., Mathe, F.O., Serres, I., Murris, M., Crognier, L., Gonzalez, M., Gronchi, F., Courbon, C., Marsland, B.J., Hillinger, S., Zalunardo, M., Schuurmans, M.M., Gaspert, A., Vrugt, B., Deplanche, K., Paprotka, T., Schmitt, M., Lefaudeux, D., Pellet, J.

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