Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model von Refolo, Lorenzo M., Pappolla, Miguel A., Malester, Brian, LaFrancois, John, Bryant-Thomas, Tara, Wang, Rong, Tint, G.Stephen, Sambamurti, Kumar, Duff, Karen

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Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology von PAPPOLLA, M. A, BRYANT-THOMAS, WOLOZIN, B, SANO, M, CRUZ-SANCHEZ, F. F, THAL, L. J, PETANCESKA, S. S, REFOLO, L. M, HERBERT, D, PACHECO, J, GARCIA, M. Fabra, MANJON, M, GIRONES, X, HENRY, T. L, MATSUBARA, E, ZAMBON, D

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A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease von Refolo, L.M., Pappolla, M.A., LaFrancois, J., Malester, B., Schmidt, S.D., Thomas-Bryant, T., Tint, G.S., Wang, R., Mercken, M., Petanceska, S.S., Duff, K.E.

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Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease von Matsubara, Etsuro, Bryant‐Thomas, Tara, Pacheco Quinto, Javier, Henry, Tracey L., Poeggeler, Burkhard, Herbert, Donald, Cruz‐Sanchez, Felix, Chyan, Yau‐Jan, Smith, Mark A., Perry, George, Shoji, Mikio, Abe, Koji, Leone, Anna, Grundke‐Ikbal, Inge, Wilson, Glen L., Ghiso, Jorge, Williams, Christina, Refolo, Lorenzo M., Pappolla, Miguel A.

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Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes von Duff, K., Knight, H., Refolo, L.M., Sanders, S., Yu, X., Picciano, M., Malester, B., Hutton, M., Adamson, J., Goedert, M., Burki, K., Davies, P.

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Modulation of Aβ peptides by estrogen in mouse models von Zheng, H., Xu, H., Uljon, S. N., Gross, R., Hardy, K., Gaynor, J., Lafrancois, J., Simpkins, J., Refolo, L. M., Petanceska, S., Wang, R., Duff, K.

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Statin therapy for Alzheimer's disease: will it work? von Petanceska, Suzana S, DeRosa, Steven, Olm, Vicki, Diaz, Nichole, Sharma, Ali, Thomas-Bryant, Tara, Duff, Karen, Pappolla, Miguel, Refolo, Lorenzo M

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Cholesterol, oxidative stress, and Alzheimer’s disease: expanding the horizons of pathogenesis von Pappolla, Miguel A, Smith, Mark A, Bryant-Thomas, Tara, Bazan, Nicolas, Petanceska, Suzana, Perry, George, Thal, Leon J, Sano, Mary, Refolo, Lorenzo M

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Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization von Gandhi, Swetal, Refolo, Lorenzo M, Sambamurti, Kumar

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A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43) von Eckman, C B, Mehta, N D, Crook, R, Perez-tur, J, Prihar, G, Pfeiffer, E, Graff-Radford, N, Hinder, P, Yager, D, Zenk, B, Refolo, L M, Prada, C M, Younkin, S G, Hutton, M, Hardy, J

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Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol von Petanceska, Suzana S, DeRosa, Steven, Sharma, Ali, Diaz, Nichole, Duff, Karen, Tint, Steven G, Refolo, Lorenzo M, Pappolla, Miguel

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Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease von Refolo, Lorenzo M, Fillit, Howard M

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Antisense-Induced Reduction of Presenilin 1 Expression Selectively Increases the Production of Amyloid beta 42 in Transfected Cells von Refolo, L M, Eckman, C, Prada, C-M, Yager, D, Sambamurti, K, Mehta, N, Hardy, J, Younkin, S G

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Glycosylphosphatidylinositol-anchored Proteins Play an Important Role in the Biogenesis of the Alzheimer's Amyloid β-Protein von Sambamurti, Kumar, Sevlever, Daniel, Koothan, Thillai, Refolo, Lawrence M., Pinnix, Inga, Gandhi, Swetal, Onstead, Luisa, Younkin, Linda, Prada, Christian M., Yager, Debra, Ohyagi, Yasumasa, Eckman, Christopher B., Rosenberry, Terrone L., Younkin, Steven G.

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Intracellular Cyclic AMP Inhibits Constitutive and Phorbol Ester‐Stimulated Secretory Cleavage of Amyloid Precursor Protein von Efthimiopoulos, Spiros, Punj, Suzy, Manolopoulos, Vangelis, Pangalos, Menelas, Wang, Gian P., Refolo, Lawrence M., Robakis, Nikolaos K.

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Targeting APP metabolism for the treatment of Alzheimer's disease von Sambamurti, Kumar, Hardy, John, Refolo, Lorenzo M., Lahiri, Debomoy K.

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Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization von Refolo, L. M., Sambamurti, K., Efthimiopoulos, S., Pappolla, M. A., Robakis, N. K.

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Nerve and epidermal growth factors induce the release of the Alzheimer Amyloid precursor from PC 12 cell cultures von Refolo, Lawrence M., Salton, Steven R.J., Anderson, John P., Mehta, Pankaj, Robakis, Nikolaos K.

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Strategies for drug discovery for cognitive aging and Alzheimer's disease von Fillit, Howard M, O'Connell, Alan W, Refolo, Lorenzo M

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Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease von Matsubara, Etsuro, Bryant‐Thomas, Tara, Pacheco, Javier, Henry, Tracey L., Poeggeler, Burkhard, Herbert, Donald, Cruz‐Sanchez, Felix, Chyan, Yau‐Jan, Smith, Mark A., Perry, George, Chain, Daniel G., Neria, Eyal, Shoji, Mikio, Abe, Koji, Leone, Anna, Grundke‐Iqbal, Inge, Wilson, Glen L., Ghiso, Jorge, Williams, Christina, Refolo, Lorenzo M., Pappolla, Miguel A.

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