ZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells von Mai, David, Boyce, Tifara, Mehta, Aakash, Reff, Jordan, Scholler, John, Sheppard, Neil C., June, Carl H.

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Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms von Tafreshi, Narges K., Pandya, Darpan N., Tichacek, Christopher J., Budzevich, Mikalai M., Wang, Zhen, Reff, Jordan N., Engelman, Robert W., Boulware, David C., Chiappori, Alberto A., Strosberg, Jonathan R., Ji, Haitao, Wadas, Thaddeus J., El-Haddad, Ghassan, Morse, David L.

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Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity von Betts, Brian C, Locke, Frederick L, Sagatys, Elizabeth M, Pidala, Joseph, Walton, Kelly, Menges, Meghan, Reff, Jordan, Saha, Asim, Djeu, Julie Y, Kiluk, John V, Lee, Marie C, Kim, Jongphil, Kang, Chang Won, Tang, Chih-Hang, Frieling, Jeremy, Lynch, Conor C, List, Alan, Rodriguez, Paulo C, Blazar, Bruce R, Conejo-Garcia, Jose R, Del Valle, Juan R, Hu, Chih-Chi, Anasetti, Claudio

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261 Synergistic antitumor effects of mouse mesothelin-directed CAR (mmeso-CAR) T cells and αCD40 in a syngeneic model of PDAC von Golinelli, Giulia, Fan, Ting-Jia, Gabunia, Khatuna, Reff, Jordan, Mai, David, Johnson, Omar, Ferraro, Zachary, Song, Decheng, Gupta, Aasha, Deshmukh, Mansi, Assenmacher, Charles-Antoine, Radaelli, Enrico, Martinez, Daniel, Rech, Andrew, Fraietta, Joseph A, Xu, He N, Wilson, Wesley V, Tchou, Julia C, Levine, Bruce L, Young, Regina M, Scholler, John, June, Carl H

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Combined disruption of T cell inflammatory regulators Regnase-1 and Roquin-1 enhances antitumor activity of engineered human T cells von Mai, David, Johnson, Omar, Reff, Jordan, Fan, Ting-Jia, Scholler, John, Sheppard, Neil C, June, Carl H

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Abstract A17: A versatile mouse-modeling platform for rapid in vivo melanoma studies von Bok, Ilah, Reff, Jordan, Nenci, Arianna, Gonzalez, Jose G., Karreth, Florian A.

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Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease von Shrestha, Bishwas, Walton, Kelly, Reff, Jordan, Sagatys, Elizabeth M., Tu, Nhan, Boucher, Justin, Li, Gongbo, Ghafoor, Tayyebb, Felices, Martin, Miller, Jeffrey S., Pidala, Joseph, Blazar, Bruce R., Anasetti, Claudio, Betts, Brian C., Davila, Marco L.

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A Versatile ES Cell-Based Melanoma Mouse Modeling Platform von Bok, Ilah, Vera, Olga, Xu, Xiaonan, Jasani, Neel, Nakamura, Koji, Reff, Jordan, Nenci, Arianna, Gonzalez, Jose G., Karreth, Florian

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Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation von Betts, Brian C., Bastian, David, Iamsawat, Supinya, Nguyen, Hung, Heinrichs, Jessica L., Wu, Yongxia, Daenthanasanmak, Anusara, Veerapathran, Anandharaman, O’Mahony, Alison, Walton, Kelly, Reff, Jordan, Horna, Pedro, Sagatys, Elizabeth M., Lee, Marie C., Singer, Jack, Chang, Ying-Jun, Liu, Chen, Pidala, Joseph, Anasetti, Claudio, Yu, Xue-Zhong

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Human CD83 Targeted Chimeric Antigen Receptor T Cell for the Prevention of Graft Versus Host Disease and Treatment of Myeloid Leukemia von Shrestha, Bishwas, Walton, Kelly, Reff, Jordan, Sagatys, Elizabeth M., Tu, Nhan, Boucher, Justin C., Ghafoor, Tayyeb, Pidala, Joseph, Blazar, Bruce R., Anasetti, Claudio, Betts, Brian C., Davila, Marco L.

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Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo‐inactivation and ILC2‐mediated tissue repair von Walton, Kelly, Walker, Kirsti, Riddle, Megan, Koehn, Brent H., Reff, Jordan, Sagatys, Elizabeth M., Linden, Michael A., Pidala, Joseph, Kim, Jongphil, Lee, Marie C., Kiluk, John V., Hui, Jane Yuet Ching, Yun, Sang Y., Xing, Yan, Stefanski, Heather, Lawrence, Harshani R., Lawrence, Nicholas J., Tolar, Jakub, Anasetti, Claudio, Blazar, Bruce R., Sebti, Said M., Betts, Brian C.

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Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity von Walton, Kelly, Fernandez, Mario R., Sagatys, Elizabeth M., Reff, Jordan, Kim, Jongphil, Lee, Marie Catherine, Kiluk, John, Hui, Jane Yuet Ching, McKenna, David, Hupp, Meghan, Forster, Colleen, Linden, Michael A., Lawrence, Nicholas J., Lawrence, Harshani R., Pidala, Joseph, Pavletic, Steven Z., Blazar, Bruce R., Sebti, Said M., Cleveland, John L., Anasetti, Claudio, Bett, Brian C.

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Human pSTAT3-Inhibited Itregs Prevent Gvhd, Maintain Anti-Leukemia Immunity, and Increase Their Potency after Metabolic Reprogramming von Walton, Kelly, Fernandez, Mario R., Sagatys, Elizabeth M., Reff, Jordan, Kim, Jongphil, Lee, Marie C., Kiluk, John V., Lawrence, Nicholas J., Lawrence, Harshani R., Pidala, Joseph A., Pavletic, Steven Z., Blazar, Bruce R., Sebti, Said M., Cleveland, John L, Anasetti, Claudio, Betts, Brian Christopher

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236 - Inhibition of Human Dendritic Cell ER Stress Reduces Gvhd Without Impairing Tregs, NK Cells, or Anti-Tumor Ctl von Betts, Brian Christopher, Locke, Frederick L., Sagatys, Elizabeth M., Pidala, Joseph A., Walton, Kelly, Menges, Meghan, Reff, Jordan, Djeu, Julie Y., Kiluk, John V., Lee, Marie C., Kang, Chang Won, List, Alan F., Del Valle, Juan R., Hu, Chih-Chi Andrew, Anasetti, Claudio

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Inhibition of Human Dendritic Cell ER Stress Reduces Gvhd Without Impairing Tregs, NK Cells, or Anti-Tumor Ctl von Betts, Brian Christopher, Locke, Frederick L., Sagatys, Elizabeth M., Pidala, Joseph A., Walton, Kelly, Menges, Meghan, Reff, Jordan, Djeu, Julie Y., Kiluk, John V., Lee, Marie C., Kang, Chang Won, List, Alan F., Del Valle, Juan R., Hu, Chih-Chi Andrew, Anasetti, Claudio

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