Loss of lamin A function increases chromatin dynamics in the nuclear interior von Bronshtein, I., Kepten, E., Kanter, I., Berezin, S., Lindner, M., Redwood, Abena B., Mai, S, Gonzalo, S., Foisner, R., Shav-Tal, Y., Garini, Y.

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CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib von Sen, Triparna, Tong, Pan, Stewart, C Allison, Cristea, Sandra, Valliani, Aly, Shames, David S, Redwood, Abena B, Fan, You Hong, Li, Lerong, Glisson, Bonnie S, Minna, John D, Sage, Julien, Gibbons, Don L, Piwnica-Worms, Helen, Heymach, John V, Wang, Jing, Byers, Lauren Averett

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Loss of A-type lamins and genomic instability von Gonzalez-Suarez, Ignacio, Redwood, Abena B., Gonzalo, Susana

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Regulating the levels of key factors in cell cycle and DNA repair: New pathways revealed by lamins von Redwood, Abena B., Gonzalez-Suarez, Ignacio, Gonzalo, Susana

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Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway von Gonzalez‐Suarez, Ignacio, Redwood, Abena B, Perkins, Stephanie M, Vermolen, Bart, Lichtensztejin, Daniel, Grotsky, David A, Morgado‐Palacin, Lucia, Gapud, Eric J, Sleckman, Barry P, Sullivan, Teresa, Sage, Julien, Stewart, Colin L, Mai, Sabine, Gonzalo, Susana

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BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells von Grotsky, David A, Gonzalez-Suarez, Ignacio, Novell, Anna, Neumann, Martin A, Yaddanapudi, Sree C, Croke, Monica, Martinez-Alonso, Montserrat, Redwood, Abena B, Ortega-Martinez, Sylvia, Feng, Zhihui, Lerma, Enrique, Ramon y Cajal, Teresa, Zhang, Junran, Matias-Guiu, Xavier, Dusso, Adriana, Gonzalo, Susana

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A dual role for A-type lamins in DNA double-strand break repair von Redwood, Abena B., Perkins, Stephanie M., Vanderwaal, Robert P., Feng, Zhihui, Biehl, Kenneth J., Gonzalez-Suarez, Ignacio, Morgado-Palacin, Lucia, Shi, Wei, Sage, Julien, Roti-Roti, Joseph L., Stewart, Colin L., Zhang, Junran, Gonzalo, Susana

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CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition von Gadhikar, Mayur A, Zhang, Jiexin, Shen, Li, Rao, Xiayu, Wang, Jing, Zhao, Mei, Kalu, Nene N, Johnson, Faye M, Byers, Lauren A, Heymach, John, Hittelman, Walter N, Udayakumar, Durga, Pandita, Raj K, Pandita, Tej K, Pickering, Curtis R, Redwood, Abena B, Piwnica-Worms, Helen, Schlacher, Katharina, Frederick, Mitchell J, Myers, Jeffrey N

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A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair von Gonzalez-Suarez, Ignacio, Redwood, Abena B, Grotsky, David A, Neumann, Martin A, Cheng, Emily H-Y, Stewart, Colin L, Dusso, Adriana, Gonzalo, Susana

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Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer von Powell, Reid T., Redwood, Abena, Liu, Xuan, Guo, Lei, Cai, Shirong, Zhou, Xinhui, Tu, Yizheng, Zhang, Xiaomei, Qi, Yuan, Jiang, Yan, Echeverria, Gloria, Feng, Ningping, Ma, XiaoYan, Giuliani, Virginia, Marszalek, Joseph R., Heffernan, Timothy P., Vellano, Christopher P., White, Jason B., Stephan, Clifford, Davies, Peter J., Moulder, Stacy, Symmans, W. Fraser, Chang, Jeffrey T., Piwnica-Worms, Helen

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The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors von Redwood, Abena B., Zhang, Xiaomei, Seth, Sahil B., Ge, Zhongqi, Bindeman, Wendy E., Zhou, Xinhui, Sinha, Vidya C., Heffernan, Timothy P., Piwnica-Worms, Helen

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Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer von Echeverria, Gloria V., Cai, Shirong, Tu, Yizheng, Shao, Jiansu, Powell, Emily, Redwood, Abena B., Jiang, Yan, McCoy, Aaron, Rinkenbaugh, Amanda L., Lau, Rosanna, Trevarton, Alexander J., Fu, Chunxiao, Gould, Rebekah, Ravenberg, Elizabeth E., Huo, Lei, Candelaria, Rosalind, Santiago, Lumarie, Adrada, Beatriz E., Lane, Deanna L., Rauch, Gaiane M., Yang, Wei T., White, Jason B., Chang, Jeffrey T., Moulder, Stacy L., Symmans, W. Fraser, Hilsenbeck, Susan G., Piwnica-Worms, Helen

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Novel roles for A-type lamins in telomere biology and the DNA damage response pathway von Gonzalez-Suarez, Ignacio, Redwood, Abena B, Perkins, Stephanie M, Vermolen, Bart, Lichtensztejin, Daniel, Grotsky, David A, Morgado-Palacin, Lucia, Gapud, Eric J, Sleckman, Barry P, Sullivan, Teresa, Sage, Julien, Stewart, Colin L, Mai, Sabine, Gonzalo, Susana

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Lamin A Δexon9 mutation leads to telomere and chromatin defects but not genomic instability von Das, Arindam, Grotsky, David A, Neumann, Martin A, Kreienkamp, Ray, Gonzalez-Suarez, Ignacio, Redwood, Abena B, Kennedy, Brian K, Stewart, Colin L, Gonzalo, Susana

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Investigating the use of Chk1 Inhibitors for Triple‐Negative Breast Cancer von Bindeman, Wendy, Redwood, Abena, Piwnica‐Worms, Helen

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Investigating the Use of Targeted Therapies for Triple‐Negative Breast Cancer von Bindeman, Wendy, Redwood, Abena, Lukose, Benjamin, Piwnica‐Worms, Helen

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Abstract 4106: High throughput chemical profiling of chemoresistant triple negative breast cancer von Powell, Reid Trenton, Redwood, Abena, Guo, Lei, Cai, Shirong, Tu, Yizheng, Jiang, Yan, Liu, Xuan, Zhou, Xinhui, Stephan, Clifford, Davies, Peter, Chang, Jeffrey T., Moulder, Stacey, Symmans, William F., Piwnica-Worms, Helen

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6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers von Yang, Hailing, Shu, Zhang, Jiang, Yongying, Mao, Weiqun, Pang, Lan, Redwood, Abena, Jeter-Jones, Sabrina L, Jennings, Nicholas B, Ornelas, Argentina, Zhou, Jinhua, Rodriguez-Aguayo, Cristian, Bartholomeusz, Geoffrey, Iles, LaKesla R, Zacharias, Niki M, Millward, Steven W, Lopez-Berestein, Gabriel, Le, Xiao-Feng, Ahmed, Ahmed A, Piwnica-Worms, Helen, Sood, Anil K, Bast, Robert C, Lu, Zhen

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Abstract 4669: Overcoming therapy resistance in stem cell-rich triple negative breast cancer through p38 MAP kinase inhibition von Hollander, Petra den, Shah, Shruti, Zhou, Xinhui, Redwood, Abena, Cai, Shi-Rong, Sobieski, Mary, Brunell, David, Stephan, Clifford, Davies, Peter, Piwnica-Worms, Helen, Moulder, Stacy, Symmans, W Fraser, Mani, Sendurai A.

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A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair: Regulation of 53BP1 protein levels von Gonzalez-Suarez, Ignacio, Redwood, Abena B, Grotsky, David A, Neumann, Martin A, Cheng, Emily H-Y, Stewart, Colin L, Dusso, Adriana, Gonzalo, Susana

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