Total Synthesis and Biological Evaluation of Pederin, Psymberin, and Highly Potent Analogs von Wan, Shuangyi, Wu, Fanghui, Rech, Jason C, Green, Michael E, Balachandran, Raghavan, Horne, W. Seth, Day, Billy W, Floreancig, Paul E

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Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis von Wubben, Thomas J, Chaudhury, Sraboni, Watch, Brennan T, Stuckey, Jeanne A, Weh, Eric, Fernando, Roshini, Goswami, Moloy, Pawar, Mercy, Rech, Jason C, Besirli, Cagri G

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Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists von Ameriks, Michael K., Ao, Hong, Carruthers, Nicholas I., Lord, Brian, Ravula, Suchitra, Rech, Jason C., Savall, Brad M., Wall, Jessica L., Wang, Qi, Bhattacharya, Anindya, Letavic, Michael A.

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The evolution of P2X7 antagonists with a focus on CNS indications von Rech, Jason C., Bhattacharya, Anindya, Letavic, Michael A., Savall, Brad M.

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Catalytic Enantioselective Addition of Arylboronic Acids to N-Boc Imines Generated in Situ von Nakagawa, Hiroshi, Rech, Jason C, Sindelar, Robert W, Ellman, Jonathan A

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Total Synthesis of Theopederin D von Green, Michael E, Rech, Jason C, Floreancig, Paul E

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Synthesis of Potent Bicyclic Bisarylimidazole c-Jun N-Terminal Kinase Inhibitors by Catalytic C−H Bond Activation von Rech, Jason C, Yato, Michihisa, Duckett, Derek, Ember, Brian, LoGrasso, Philip V, Bergman, Robert G, Ellman, Jonathan A

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Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival? von Sun, Duxin, Macedonia, Christian, Chen, Zhigang, Chandrasekaran, Sriram, Najarian, Kayvan, Zhou, Simon, Cernak, Tim, Ellingrod, Vicki L., Jagadish, H. V., Marini, Bernard, Pai, Manjunath, Violi, Angela, Rech, Jason C., Wang, Shaomeng, Li, Yan, Athey, Brian, Omenn, Gilbert S.

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Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease von Yuan, Xinrui, Jiang, Hua, Fu, Denggang, Robida, Aaron, Rajanayake, Krishani, Yuan, Hebao, Wen, Bo, Sun, Duxin, Watch, Brennan T., Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Paczesny, Sophie, Rech, Jason C., Yang, Chao-Yie

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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4- d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist von Maher, Michael P., Bhattacharya, Anindya, Ao, Hong, Swanson, Nadia, Wu, Nyan-Tsz, Freedman, Jamie, Kansagara, Mena, Scott, Brian, Li, Dong H., Eckert, William A., Liu, Yi, Sepassi, Kia, Rizzolio, Michele, Fitzgerald, Anne, Liu, Jing, Branstetter, Bryan J., Rech, Jason C., Lebsack, Alec D., Breitenbucher, J. Guy, Wickenden, Alan D., Chaplan, Sandra R.

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Studies of Structure–Activity Relationship of 2‑(Pyrrolidin-1ylmethyl)‑1H‑pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation von Yuan, Xinrui, Rech, Jason C., Ramaraju, Andhavaram, Patil, Amol D., Rajanayake, Krishani, Yuan, Hebao, Kazemi Sabzvar, Mona, Mandal, Mousumi, Cho, Eun Bee, Wen, Bo, Jiang, Jianxiong, Leo, M. Dennis, Singh, Udai P., Sun, Duxin, Yang, Chao-Yie

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Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1 H -pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation von Yuan, Xinrui, Rech, Jason C, Ramaraju, Andhavaram, Patil, Amol D, Rajanayake, Krishani, Yuan, Hebao, Kazemi Sabzvar, Mona, Mandal, Mousumi, Cho, Eun Bee, Wen, Bo, Jiang, Jianxiong, Leo, M Dennis, Singh, Udai P, Sun, Duxin, Yang, Chao-Yie

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Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists von Rudolph, Dale A., Alcazar, Jesus, Ameriks, Michael K., Anton, Ana Belen, Ao, Hong, Bonaventure, Pascal, Carruthers, Nicholas I., Chrovian, Christa C., De Angelis, Meri, Lord, Brian, Rech, Jason C., Wang, Qi, Bhattacharya, Anindya, Andres, Jose Ignacio, Letavic, Michael A.

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Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2‑(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation‑2 (ST2) Inhibitors von Yuan, Xinrui, Jiang, Hua, Fu, Denggang, Rech, Jason C., Robida, Aaron, Rajanayake, Krishani, Yuan, Hebao, He, Miao, Wen, Bo, Sun, Duxin, Liu, Chen, Chinnaswamy, Krishnapriya, Stuckey, Jeanne A., Paczesny, Sophie, Yang, Chao-Yie

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1 H -Pyrrolo[3,2- b ]pyridine GluN2B-Selective Negative Allosteric Modulators von Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A

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1H‑Pyrrolo[3,2‑b]pyridine GluN2B-Selective Negative Allosteric Modulators von Chrovian, Christa C, Soyode-Johnson, Akinola, Wall, Jessica L, Rech, Jason C, Schoellerman, Jeff, Lord, Brian, Coe, Kevin J, Carruthers, Nicholas I, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A

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From proteomics to discovery of first-in-class ST2 inhibitors active in vivo von Ramadan, Abdulraouf M, Daguindau, Etienne, Rech, Jason C, Chinnaswamy, Krishnapriya, Zhang, Jilu, Hura, Greg L, Griesenauer, Brad, Bolten, Zachary, Robida, Aaron, Larsen, Martha, Stuckey, Jeanne A, Yang, Chao-Yie, Paczesny, Sophie

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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonis... von Rech, Jason C., Bhattacharya, Anindya, Branstetter, Bryan J., Love, Christopher J., Leenaerts, Joseph E., Cooymans, Ludwig P., Eckert, William A., Ao, Hong, Wang, Qi, Chaplan, Sandra R., Wickenden, Alan D., Lebsack, Alec D., Breitenbucher, J. Guy

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Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3‑a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain von Chrovian, Christa C, Soyode-Johnson, Akinola, Ao, Hong, Bacani, Genesis M, Carruthers, Nicholas I, Lord, Brian, Nguyen, Leslie, Rech, Jason C, Wang, Qi, Bhattacharya, Anindya, Letavic, Michael A

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Concise and Stereoselective Synthesis of the N7−C25 Fragment of Psymberin von Rech, Jason C, Floreancig, Paul E

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