ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A von Williamson, Chris T., Miller, Rowan, Pemberton, Helen N., Jones, Samuel E., Campbell, James, Konde, Asha, Badham, Nicholas, Rafiq, Rumana, Brough, Rachel, Gulati, Aditi, Ryan, Colm J., Francis, Jeff, Vermulen, Peter B., Reynolds, Andrew R., Reaper, Philip M., Pollard, John R., Ashworth, Alan, Lord, Christopher J.

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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR von Reaper, Philip M, Griffiths, Matthew R, Long, Joanna M, Charrier, Jean-Damien, MacCormick, Somhairle, Charlton, Peter A, Golec, Julian M C, Pollard, John R

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities von Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas

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ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses von Jossé, Rozenn, Martin, Scott E, Guha, Rajarshi, Ormanoglu, Pinar, Pfister, Thomas D, Reaper, Philip M, Barnes, Christopher S, Jones, Julie, Charlton, Peter, Pollard, John R, Morris, Joel, Doroshow, James H, Pommier, Yves

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The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy von Prevo, Remko, Fokas, Emmanouil, Reaper, Philip M., Charlton, Peter A., Pollard, John R., McKenna, W. Gillies, Muschel, Ruth J., Brunner, Thomas B.

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Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 von Hall, Amy B, Newsome, Dave, Wang, Yuxin, Boucher, Diane M, Eustace, Brenda, Gu, Yong, Hare, Brian, Johnson, Mac A, Milton, Sean, Murphy, Cheryl E, Takemoto, Darin, Tolman, Crystal, Wood, Mark, Charlton, Peter, Charrier, Jean-Damien, Furey, Brinley, Golec, Julian, Reaper, Philip M, Pollard, John R

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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents von Charrier, Jean-Damien, Durrant, Steven J, Golec, Julian M. C, Kay, David P, Knegtel, Ronald M. A, MacCormick, Somhairle, Mortimore, Michael, O'Donnell, Michael E, Pinder, Joanne L, Reaper, Philip M, Rutherford, Alistair P, Wang, Paul S. H, Young, Stephen C, Pollard, John R

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM von HICKSON, Ian, YAN ZHAO, RICHARDSON, Caroline J, GREEN, Sharon J, MARTIN, Niall M. B, ORR, Alisdair I, REAPER, Philip M, JACKSON, Stephen P, CURTIN, Nicola J, SMITH, Graeme C. M

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities von Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas

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A DNA damage checkpoint response in telomere-initiated senescence von Fagagna, Fabrizio d'Adda di, Jackson, Stephen P, Reaper, Philip M, Clay-Farrace, Lorena, Fiegler, Heike, Carr, Philippa, von Zglinicki, Thomas, Saretzki, Gabriele, Carter, Nigel P

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Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response von Smits, Veronique A.J., Reaper, Philip M., Jackson, Stephen P.

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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA von Swan, Michael K., Legris, Valerie, Tanner, Adam, Reaper, Philip M., Vial, Sarah, Bordas, Rebecca, Pollard, John R., Charlton, Peter A., Golec, Julian M. C., Bertrand, Jay A.

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Development of pharmacodynamic biomarkers for ATR inhibitors von Chen, Tao, Middleton, Fiona K., Falcon, Susanna, Reaper, Philip M., Pollard, John R., Curtin, Nicola J.

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Activation of the DNA damage response by telomere attrition: a passage to cellular senescence von Reaper, Philip M, di Fagagna, Fabrizio d'Adda, Jackson, Stephen P

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The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes von JONES, Gillian G, REAPER, Philip M, PETTITT, Andrew R, SHERRINGTON, Paul D

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Activation of the DNA Damage Response by Telomere Attrition: A Passage to Cellular Senescence von Reaper, Philip M., Fagagna, Fabrizio d'Adda di, Jackson, Stephen P.

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Compounds useful as inhibitors of atr kinase and combination therapies thereof von REAPER, PHILIP M, POLLARD, JOHN R, ASMAL, MOHAMMED, HAMMOND, ESTER M

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Methods and means for the treatment of disorders associated with cellular senescence von JACKSON STEPHEN, D'ADDAFAGAGNA FABRIZIO, REAPER PHILIP M

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Compounds useful as inhibitors of ATR kinase and combination therapies thereof von REAPER, PHILIP M, POLLARD, JOHN R, ASMAL, MOHAMMED, HAMMOND, ESTER M

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Compounds useful as inhibitors of ATR kinase and combination therapies thereof von REAPER, PHILIP M, POLLARD, JOHN R, ASMAL, MOHAMMED, HAMMOND, ESTER M

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