Anorectal function in elderly patients with fecal impaction von Read, N.W., Abouzekry, Laila, Read, Maria G., Howell, P., Ottewell, D., Donnelly, T.Carmel

Volltext

Chronic diarrhea of unknown origin von Read, Nicholas W., Krejs, Guenter J., Read, Maria G., Santa Ana, Carol A., Morawski, Stephen G., Fordtran, John S.

Volltext

A clinical study of patients with fecal incontinence and diarrhea von Read, N W, Harford, W V, Schmulen, A C, Read, M G, Santa Ana, C, Fordtran, J S

Volltext

A report of five patients with large-volume secretory diarrhea but no evidence of endocrine tumor or laxative abuse von Read, N W, Read, M G, Krejs, G J, Hendler, R S, Davis, G, Fordtran, J S

Volltext

Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations von Beggs, Grace A, Ayala, Julio C, Kavanaugh, Logan G, Read, Timothy D, Hooks, Grace M, Schumacher, Maria A, Shafer, William M, Brennan, Richard G

Volltext

Automated design of ligands to polypharmacological profiles von Besnard, Jérémy, Ruda, Gian Filippo, Setola, Vincent, Abecassis, Keren, Rodriguiz, Ramona M., Huang, Xi-Ping, Norval, Suzanne, Sassano, Maria F., Shin, Antony I., Webster, Lauren A., Simeons, Frederick R. C., Stojanovski, Laste, Prat, Annik, Seidah, Nabil G., Constam, Daniel B., Bickerton, G. Richard, Read, Kevin D., Wetsel, William C., Gilbert, Ian H., Roth, Bryan L., Hopkins, Andrew L.

Volltext

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition von Wyllie, Susan, Brand, Stephen, Thomas, Michael, De Rycker, Manu, Chung, Chun-wa, Pena, Imanol, Bingham, Ryan P., Bueren-Calabuig, Juan A., Cantizani, Juan, Cebrian, David, Craggs, Peter D., Ferguson, Liam, Goswami, Panchali, Hobrath, Judith, Howe, Jonathan, Jeacock, Laura, Ko, Eun-Jung, Korczynska, Justyna, MacLean, Lorna, Manthri, Sujatha, Martinez, Maria S., Mata-Cantero, Lydia, Moniz, Sonia, Nühs, Andrea, Osuna-Cabello, Maria, Pinto, Erika, Riley, Jennifer, Robinson, Sharon, Rowland, Paul, Simeons, Frederick R. C., Shishikura, Yoko, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Gaza, Elisabet Viayna, Wall, Richard J., Zuccotto, Fabio, Horn, David, Ferguson, Michael A. J., Fairlamb, Alan H., Fiandor, Jose M., Martin, Julio, Gray, David W., Miles, Timothy J., Gilbert, Ian H., Read, Kevin D., Marco, Maria, Wyatt, Paul G.

Volltext

A novel multiple-stage antimalarial agent that inhibits protein synthesis von Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus C. S., Norcross, Neil R., Grimaldi, Raffaella, Otto, Thomas D., Proto, William R., Blagborough, Andrew M., Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M., Abraham, Tara S., Almeida, Mariana J., Pradhan, Anupam, Porzelle, Achim, Martínez, María Santos, Bolscher, Judith M., Woodland, Andrew, Luksch, Torsten, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M., Churcher, Tom S., Sala, Katarzyna A., Zakutansky, Sara E., Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M., Sauerwein, Robert W., Dechering, Koen J., Noviyanti, Rintis, Campo, Brice, Frearson, Julie A., Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G., Leroy, Didier, Siegl, Peter, Delves, Michael J., Kyle, Dennis E., Wittlin, Sergio, Marfurt, Jutta, Price, Ric N., Sinden, Robert E., Winzeler, Elizabeth A., Charman, Susan A., Bebrevska, Lidiya, Gray, David W., Campbell, Simon, Fairlamb, Alan H., Willis, Paul A., Rayner, Julian C., Fidock, David A., Read, Kevin D., Gilbert, Ian H.

Volltext

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target von Wilson, Caroline, Ray, Peter, Zuccotto, Fabio, Hernandez, Jorge, Aggarwal, Anup, Mackenzie, Claire, Caldwell, Nicola, Taylor, Malcolm, Huggett, Margaret, Mathieson, Michael, Murugesan, Dinakaran, Smith, Alasdair, Davis, Susan, Cocco, Mattia, Parai, Maloy K, Acharya, Arjun, Tamaki, Fabio, Scullion, Paul, Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Lopez-Román, Eva Maria, Torres-Gómez, Pedro Alfonso, Toledo, Ana Maria, Guijarro-Lopez, Laura, Camino, Isabel, Engelhart, Curtis A, Schnappinger, Dirk, Massoudi, Lisa M, Lenaerts, Anne, Robertson, Gregory T, Walpole, Chris, Matthews, David, Floyd, David, Sacchettini, James C, Read, Kevin D, Encinas, Lourdes, Bates, Robert H, Green, Simon R, Wyatt, Paul G

Volltext

A laboratory-based predictive pathway for the development of Neisseria gonorrhoeae high-level resistance to corallopyronin A, an inhibitor of bacterial RNA polymerase von Balthazar, Jacqueline T, Golparian, Daniel, Unemo, Magnus, Read, Timothy D, Grosse, Miriam, Stadler, Marc, Pfarr, Kenneth, Schiefer, Andrea, Hoerauf, Achim, Edwards, Jennifer L, Vassylyev, Dmitry G, Shafer, William M

Volltext

Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease von McGonagle, Kate, Tarver, Gary J., Cantizani, Juan, Cotillo, Ignacio, Dodd, Peter G., Ferguson, Liam, Gilbert, Ian H., Marco, Maria, Miles, Tim, Naylor, Claire, Osuna-Cabello, Maria, Paterson, Christy, Read, Kevin D., Pinto, Erika G., Riley, Jennifer, Scullion, Paul, Shishikura, Yoko, Simeons, Frederick, Stojanovski, Laste, Svensen, Nina, Thomas, John, Wyatt, Paul G., Manzano, Pilar, De Rycker, Manu, Thomas, Michael G.

Volltext

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 von Lundgren, Jens D, Grund, Birgit, Barkauskas, Christina E, Holland, Thomas L, Gottlieb, Robert L, Sandkovsky, Uriel, Brown, Samuel M, Knowlton, Kirk U, Self, Wesley H, Files, D Clark, Jain, Mamta K, Benfield, Thomas, Bowdish, Michael E, Leshnower, Bradley G, Baker, Jason V, Jensen, Jens-Ulrik, Gardner, Edward M, Ginde, Adit A, Harris, Estelle S, Johansen, Isik S, Markowitz, Norman, Matthay, Michael A, Østergaard, Lars, Chang, Christina C, Davey, Victoria J, Goodman, Anna, Higgs, Elizabeth S, Murray, Daniel D, Murray, Thomas A, Paredes, Roger, Parmar, Mahesh K B, Phillips, Andrew N, Reilly, Cavan, Sharma, Shweta, Dewar, Robin L, Teitelbaum, Marc, Wentworth, Deborah, Cao, Huyen, Klekotka, Paul, Babiker, Abdel G, Gelijns, Annetine C, Kan, Virginia L, Polizzotto, Mark N, Thompson, B Taylor, Lane, H Clifford, Neaton, James D

Volltext

Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis von Thomas, Michael, Brand, Stephen, De Rycker, Manu, Zuccotto, Fabio, Lukac, Iva, Dodd, Peter G, Ko, Eun-Jung, Manthri, Sujatha, McGonagle, Kate, Osuna-Cabello, Maria, Riley, Jennifer, Pont, Caterina, Simeons, Frederick, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Viayna, Elisabet, Fiandor, Jose M, Martin, Julio, Wyatt, Paul G, Miles, Timothy J, Read, Kevin D, Marco, Maria, Gilbert, Ian H

Volltext

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors von Thomas, Michael G., McGonagle, Kate, Rowland, Paul, Robinson, David A., Dodd, Peter G., Camino-Díaz, Isabel, Campbell, Lorna, Cantizani, Juan, Castañeda, Pablo, Conn, Daniel, Craggs, Peter D., Edwards, Darren, Ferguson, Liam, Fosberry, Andrew, Frame, Laura, Goswami, Panchali, Hu, Xiao, Korczynska, Justyna, MacLean, Lorna, Martin, Julio, Mutter, Nicole, Osuna-Cabello, Maria, Paterson, Christy, Peña, Imanol, Pinto, Erika G., Pont, Caterina, Riley, Jennifer, Shishikura, Yoko, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Wrobel, Karolina, Young, Robert J., Zmuda, Filip, Zuccotto, Fabio, Read, Kevin D., Gilbert, Ian H., Marco, Maria, Miles, Timothy J., Manzano, Pilar, De Rycker, Manu

Volltext

Hansen Solubility Parameters Clarify the Role of the Primary and Secondary Hydroxyl Groups on the Remarkable Self-Assembly of 1:3,2:4-Dibenzylidene Sorbitol von Nasr, Pedram, Corradini, Maria G, Hill, Jarvis, Read, Stuart T, Rosendahl, Scott M, Weiss, Richard G, Auzanneau, France-Isabelle, Rogers, Michael A

Volltext

Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis von Thomas, Michael G, De Rycker, Manu, Ajakane, Myriam, Albrecht, Sébastian, Álvarez-Pedraglio, Ana Isabel, Boesche, Markus, Brand, Stephen, Campbell, Lorna, Cantizani-Perez, Juan, Cleghorn, Laura A.T, Copley, Royston C.B, Crouch, Sabrinia D, Daugan, Alain, Drewes, Gerard, Ferrer, Santiago, Ghidelli-Disse, Sonja, Gonzalez, Silvia, Gresham, Stephanie L, Hill, Alan P, Hindley, Sean J, Lowe, Rhiannon M, MacKenzie, Claire J, MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Miguel-Siles, Juan, Nguyen, Van Loc, Norval, Suzanne, Osuna-Cabello, Maria, Woodland, Andrew, Patterson, Stephen, Pena, Imanol, Quesada-Campos, Maria Teresa, Reid, Iain H, Revill, Charlotte, Riley, Jennifer, Ruiz-Gomez, Jose Ramon, Shishikura, Yoko, Simeons, Frederick R.C, Smith, Alasdair, Smith, Victoria C, Spinks, Daniel, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Underwood, Tim, Gray, David W, Fiandor, Jose M, Gilbert, Ian H, Wyatt, Paul G, Read, Kevin D, Miles, Timothy J

Volltext

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May–September 2009) von Nguyen-Van-Tam, J S, Openshaw, P J M, Hashim, A, Gadd, E M, Lim, W S, Semple, M G, Read, R C, Taylor, B L, Brett, S J, McMenamin, J, Enstone, J E, Armstrong, C, Nicholson, K G

Volltext

Molecular and genomic characterisation of a panel of human anal cancer cell lines von Guerra, Glen R., Kong, Joseph C., Millen, Rosemary M., Read, Matthew, Liu, David S., Roth, Sara, Sampurno, Shienny, Sia, Joseph, Bernardi, Maria-Pia, Chittleborough, Timothy J., Behrenbruch, Corina C., Teh, Jiasian, Xu, Huiling, Haynes, Nicole M., Yu, Jiaan, Lupat, Richard, Hawkes, David, Di Costanzo, Natasha, Tothill, Richard W., Mitchell, Catherine, Ngan, Samuel Y., Heriot, Alexander G., Ramsay, Robert G., Phillips, Wayne A.

Volltext

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity von Green, Simon R, Wilson, Caroline, Eadsforth, Thomas C, Punekar, Avinash S, Tamaki, Fabio K, Wood, Gavin, Caldwell, Nicola, Forte, Barbara, Norcross, Neil R, Kiczun, Michael, Post, John M, Lopez-Román, Eva Maria, Engelhart, Curtis A, Lukac, Iva, Zuccotto, Fabio, Epemolu, Ola, Boshoff, Helena I M, Schnappinger, Dirk, Walpole, Chris, Gilbert, Ian H, Read, Kevin D, Wyatt, Paul G, Baragaña, Beatriz

Volltext

Utilizing Molecular Epidemiology and Citizen Science for the Surveillance of Lagoviruses in Australia von Peng, Nias Y G, Hall, Robyn N, Huang, Nina, West, Peter, Cox, Tarnya E, Mahar, Jackie E, Mason, Hugh, Campbell, Susan, O'Connor, Tiffany, Read, Andrew J, Patel, Kandarp K, Taggart, Patrick L, Smith, Ina L, Strive, Tanja, Jenckel, Maria

Volltext