Altered Gut Microbiome Composition and Function Are Associated With Gut Barrier Dysfunction in Healthy Relatives of Patients With Crohn’s Disease von Leibovitzh, Haim, Lee, Sun-Ho, Xue, Mingyue, Raygoza Garay, Juan Antonio, Hernandez-Rocha, Cristian, Madsen, Karen L., Meddings, Jonathan B., Guttman, David S., Espin-Garcia, Osvaldo, Smith, Michelle I., Goethel, Ashleigh, Griffiths, Anne M., Moayyedi, Paul, Steinhart, A. Hillary, Panaccione, Remo, Huynh, Hien Q., Jacobson, Kevan, Aumais, Guy, Mack, David R., Abreu, Maria T., Bernstein, Charles N., Marshall, John K., Turner, Dan, Xu, Wei, Turpin, Williams, Croitoru, Kenneth

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Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis von Leibovitzh, Haim, Lee, Sun-Ho, Raygoza Garay, Juan Antonio, Espin-Garcia, Osvaldo, Xue, Mingyue, Neustaeter, Anna, Goethel, Ashleigh, Huynh, Hien Q, Griffiths, Anne M, Turner, Dan, Madsen, Karen L, Moayyedi, Paul, Steinhart, A Hillary, Silverberg, Mark S, Deslandres, Colette, Bitton, Alain, Mack, David R, Jacobson, Kevan, Cino, Maria, Aumais, Guy, Bernstein, Charles N, Panaccione, Remo, Weiss, Batia, Halfvarson, Jonas, Xu, Wei, Turpin, Williams, Croitoru, Kenneth, Abreu, Maria, Beck, Paul, Bernstein, Charles N, Croitoru, Kenneth, Dieleman, Levinus A, Feagan, Brian, Griffiths, Anne M, Guttman, David S, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O, Madsen, Karen L, Marshall, John K, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark S, Snapper, Scott, Stadnyk, Andy, Steinhart, A Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien Q, Hyams, Jeff, Mack, David R, McGrath, Jerry, Otley, Anthony, Panaccione, Remo

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Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease von Turpin, Williams, Lee, Sun-Ho, Raygoza Garay, Juan Antonio, Madsen, Karen L., Meddings, Jonathan B., Bedrani, Larbi, Power, Namita, Espin-Garcia, Osvaldo, Xu, Wei, Smith, Michelle I., Griffiths, Anne M., Moayyedi, Paul, Turner, Dan, Seidman, Ernest G., Steinhart, A. Hillary, Marshall, John K., Jacobson, Kevan, Mack, David, Huynh, Hien, Bernstein, Charles N., Paterson, Andrew D., Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Baldassano, Robert, Griffiths, Anne M., Hedin, Charlotte, Hussey, Seamus, Hyams, Hien, Keljo, David, Kevans, David, Lees, Charlie, Murthy, Sanjay, Panaccione, Remo, Parekh, Nimisha, Plamondon, Sophie, Radford-Smith, Graham, Rosh, Joel, Rubin, David, Schultz, Michael, Siegel, Corey, Turner, Dan, Croitoru, Kenneth

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P321 Development and validation of an Integrated Risk Score for future risk of Crohn’s disease in healthy first-degree relatives: The CCC-GEM Project, a multicentre prospective coh... von Lee Dr, S H, Turpin, W, Espin-Garcia, O, Leibovitzh, H, Xue, M, Raygoza-Garay, J A, Grana, L, Smith, M I, Goethel, A, Madsen L., K, Avni-Biron, I, Dotan, I, Shomron, B H, Griffiths, A M, Steinhart, A H, Silverberg, M S, Turner, D, Bernstein, C N, Feagan, B G, Moayeddi, P, Paterson, A, Guttman, D, Xu, W, Croitoru, K

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Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation von Turpin, Williams, Dong, Mei, Sasson, Gila, Raygoza Garay, Juan Antonio, Espin-Garcia, Osvaldo, Lee, Sun-Ho, Neustaeter, Anna, Smith, Michelle I., Leibovitzh, Haim, Guttman, David S., Goethel, Ashleigh, Griffiths, Anne M., Huynh, Hien Q., Dieleman, Levinus A., Panaccione, Remo, Steinhart, A. Hillary, Silverberg, Mark S., Aumais, Guy, Jacobson, Kevan, Mack, David, Murthy, Sanjay K., Marshall, John K., Bernstein, Charles N., Abreu, Maria T., Moayyedi, Paul, Paterson, Andrew D., Abreu, Maria, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Baldassano, Robert, Griffiths, Anne M., Hedin, Charlotte, Hussey, Seamus, Hyams, Hien, Keljo, David, Kevans, David, Lees, Charlie, Murthy, Sanjay, Panaccione, Remo, Parekh, Nimisha, Plamondon, Sophie, Radford-Smith, Graham, Rosh, Joel, Rubin, David, Schultz, Michael, Siegel, Corey, Xu, Wei, Croitoru, Kenneth

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P701 Compositional and functional alterations of the gut microbiome are associated with impaired intestinal permeability in healthy relatives of patients with Crohn’s disease von Leibovitzh, H, Lee, S H, Xue, M, Raygoza Garay, J A, Hernandez-Rocha, C, Madsen, K L, Meddings, J B, Guttman, D S, Espin-Garcia, O, Smith, M I, Goethel, A, Moayyedi, P, Steinhart, A H, Panancionne, R, Huynh, H, Jacobson, K, Aumais, G, Mack, D R, Abreu, M, Bernstein, C N, Marshall, J K, Turner, D, Xu, W, Turpin, W, Croitoru, K

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A17 ASSOCIATION BETWEEN HOST INFLAMMATION-RELATED PROTEOMICS AND GUT MICROBIOME IN HEALTHY FIRST-DEGREE RELATIVES OF CROHN’S DISEASE PATIENTS von Raygoza Garay, J, Turpin, W, Smith, M, Goethel, A, Guttman, D S, Croitoru, K

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P700 The GEM Project: Stool metabolomic profile is associated with microbiome risk score and with future onset of Crohn’s disease in healthy first-degree relatives von Lee, S H, Raygoza Garay, J A, Turpin, W, Smith, M I, Goethel, A, Griffiths, A, Moayyedi, P, Espin-Garcia, O, Abreu, M, Aumais, G, Bernstein, C N, Biron, I, Cino, M, Deslandres, C, Dotan, I, El-Matary, W, Feagan, B, Guttman, D, Huynh, H, Hyams, J, Jacobson, K, Mack, D, Marshall, J, Otley, A, Panaccione, R, Ropeleski, M, Silverberg, M S, Steinhart, A H, Turner, D, Yerushalmi, B, Xu, W, Croitoru, K

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A223 THE GEM PROJECT: ASSOCIATIONS OF DIETARY PATTERNS WITH MICROBIOME AND FECAL CALPROTECTIN IN HEALTHY FIRST-DEGREE RELATIVES OF CROHN’S DISEASE PATIENTS von Sasson, G, Raygoza Garay, J, Turpin, W, Power, N, Smith, M, Guttman, D S, Research Consortium, T, Croitoru, K

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A29 NOVEL FECAL BIOMARKERS THAT PRECEDE CLINICAL DIAGNOSIS OF ULCERATIVE COLITIS von Galipeau, H J, CAMINERO FERNANDEZ, A, Turpin, W, Bermudez-Brito, M, Santiago, A, Libertucci, J, Constante, M, Raygoza Garay, J, Rueda, G H, Clarizio, A V, Smith, M I, Surette, M, Bercik, P, Croitoru, K, Verdu, E

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A221 CROHN’S DISEASE POLYGENIC RISK SCORE IS ASSOCIATED WITH FECAL CALPROTECTIN CONCENTRATION IN ASYMPTOMATIC FIRST-DEGREE RELATIVES OF CROHN’S DISEASE PATIENTS von Lee, S, Shestopaloff, K, Espin-Garcia, O, Turpin, W, Raygoza Garay, J, Power, N, Smith, M, Silverberg, M, Xu, W, Paterson, A D, Croitoru, K

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A238 ALTERED GUT MICROBIOME COMPOSITION AND FUNCTION ARE ASSOCIATED WITH GUT BARRIER DYSFUNCTION IN HEALTHY RELATIVES OF CROHN’S DISEASE PATIENTS von Leibovitzh, H, Lee, S, Xue, M, Raygoza Garay, J, Hernandez-Rocha, C, Madsen, K, Meddings, J, Guttmen, D S, Espin Garcia, O, Goethel, A, Griffiths, A, Moayyedi, P, Huynh, H Q, Jacobson, K, Mack, D R, Abreu, M, Bernstein, C N, Marshall, J, Turner, D, Xu, W, Turpin, W, Croitoru, K

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A236 ASSOCIATION OF STOOL METABOLOMIC PROFILE AND MICROBIOME COMPOSITION RISK SCORE WITH FUTURE ONSET OF CROHN’S DISEASE von Lee, S, Raygoza Garay, J, Turpin, W, Smith, M I, Goethel, A, Griffiths, A, Moayyedi, P, Espin-Garcia, O, Aumais, G, Bernstein, C N, Avni-Biron, I, Cino, M, Deslandres, C, Dotan, I, El-Matary, W, Feagan, B G, Guttmen, D S, Huynh, H Q, Hyams, J, Jacobson, K, Mack, D R, Marshall, J, Otley, A, Panaccione, R, Silverberg, M S, Steinhart, H, Turner, D, Xu, W, Croitoru, K

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A17 ASSOCIATION BETWEEN HOST INFLAMMATION-RELATED PROTEOMICS AND GUT MICROBIOME IN HEALTHY FIRST-DEGREE RELATIVES OF CROHN’S DISEASE PATIENTS von Raygoza Garay, J, Turpin, W, Smith, M, Goethel, A, Guttman, D S, Croitoru, K

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Enhanced heat tolerance of virus-infected aphids leads to niche expansion and reduced interspecific competition von Navas, Carlos, Marden, James, Mescher, M, De Moraes, Consuelo, Pincebourde, S, Sandoval-Mojica, Andres, Raygoza-Garay, J, Holguin, German, Rajotte, Edwin, Carlo, Tomas

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The taxonomic name resolution service: an online tool for automated standardization of plant names von Boyle, Brad, Hopkins, Nicole, Lu, Zhenyuan, Raygoza Garay, Juan Antonio, Mozzherin, Dmitry, Rees, Tony, Matasci, Naim, Narro, Martha L, Piel, William H, McKay, Sheldon J, Lowry, Sonya, Freeland, Chris, Peet, Robert K, Enquist, Brian J

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CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression von Kohlmeyer, Jordan L, Lingo, Joshua J, Kaemmer, Courtney A, Scherer, Amanda, Warrier, Akshaya, Voigt, Ellen, Raygoza Garay, Juan A, McGivney, Gavin R, Brockman, Qierra R, Tang, Amy, Calizo, Ana, Pollard, Kai, Zhang, Xiaochun, Hirbe, Angela C, Pratilas, Christine A, Leidinger, Mariah, Breheny, Patrick, Chimenti, Michael S, Sieren, Jessica C, Monga, Varun, Tanas, Munir R, Meyerholz, David K, Darbro, Benjamin W, Dodd, Rebecca D, Quelle, Dawn E

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Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis von Galipeau, Heather J., Caminero, Alberto, Turpin, Williams, Bermudez-Brito, Miriam, Santiago, Alba, Libertucci, Josie, Constante, Marco, Raygoza Garay, Juan Antonio, Rueda, Gaston, Armstrong, Sarah, Clarizio, Alex, Smith, Michelle I., Surette, Michael G., Bercik, Premysl, Beck, Paul, Bernstein, Charles, Croitoru, Kenneth, Dieleman, Leo, Feagan, Brian, Griffiths, Anne, Guttman, David, Jacobson, Kevan, Kaplan, Gilaad, Krause, Denis O., Madsen, Karen, Marshall, John, Moayyedi, Paul, Ropeleski, Mark, Seidman, Ernest, Silverberg, Mark, Snapper, Scott, Stadnyk, Andy, Steinhart, Hillary, Surette, Michael, Turner, Dan, Walters, Thomas, Vallance, Bruce, Aumais, Guy, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Huynh, Hien, Hyams, Jeff, Mack, David, McGrath, Jerry, Otley, Anthony, Panancionne, Remo, Croitoru, Kenneth, Verdu, Elena F.

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Stochastic expression and epigenetic memory at the yeast HO promoter von Zhang, Qian, Yoon, Youngdae, Yu, Yaxin, Parnell, Emily J., Garay, Juan Antonio Raygoza, Mwangi, Michael M., Cross, Frederick R., Stillman, David J., Bai, Lu

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Identification of Novel Seroreactive Antigens in Johne's Disease Cattle by Using the Mycobacterium tuberculosis Protein Array von Bannantine, John P, Campo, Joseph J, Li, Lingling, Randall, Arlo, Pablo, Jozelyn, Praul, Craig A, Raygoza Garay, Juan Antonio, Stabel, Judith R, Kapur, Vivek

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