Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease von Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R

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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses von Lo, Michael K., Jordan, Robert, Arvey, Aaron, Sudhamsu, Jawahar, Shrivastava-Ranjan, Punya, Hotard, Anne L., Flint, Mike, McMullan, Laura K., Siegel, Dustin, Clarke, Michael O., Mackman, Richard L., Hui, Hon C., Perron, Michel, Ray, Adrian S., Cihlar, Tomas, Nichol, Stuart T., Spiropoulou, Christina F.

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Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy von Murakami, Eisuke, Wang, Ting, Park, Yeojin, Hao, Jia, Lepist, Eve-Irene, Babusis, Darius, Ray, Adrian S

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Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents von Goedeke, Leigh, Bates, Jamie, Vatner, Daniel F., Perry, Rachel J., Wang, Ting, Ramirez, Ricardo, Li, Li, Ellis, Matthew W., Zhang, Dongyan, Wong, Kari E., Beysen, Carine, Cline, Gary W., Ray, Adrian S., Shulman, Gerald I.

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Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance von Zamek‐Gliszczynski, Maciej J., Taub, Mitchell E., Chothe, Paresh P., Chu, Xiaoyan, Giacomini, Kathleen M., Kim, Richard B., Ray, Adrian S., Stocker, Sophie L., Unadkat, Jashvant D., Wittwer, Matthias B., Xia, Cindy, Yee, Sook‐Wah, Zhang, Lei, Zhang, Yan

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Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat von Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P., Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S.

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Structural basis for RNA replication by the hepatitis C virus polymerase von Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.

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Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition von Liclican, Albert, Serafini, Loredana, Xing, Weimei, Czerwieniec, Gregg, Steiner, Bart, Wang, Ting, Brendza, Katherine M., Lutz, Justin D., Keegan, Kathleen S., Ray, Adrian S., Schultz, Brian E., Sakowicz, Roman, Feng, Joy Y.

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Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides von Arnold, Jamie J, Sharma, Suresh D, Feng, Joy Y, Ray, Adrian S, Smidansky, Eric D, Kireeva, Maria L, Cho, Aesop, Perry, Jason, Vela, Jennifer E, Park, Yeojin, Xu, Yili, Tian, Yang, Babusis, Darius, Barauskus, Ona, Peterson, Blake R, Gnatt, Averell, Kashlev, Mikhail, Zhong, Weidong, Cameron, Craig E

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Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro von LEPIST, Eve-Irene, PHAN, Truc K, ROY, Anupma, TONG, Leah, MACLENNAN, Kelly, MURRAY, Bernard, RAY, Adrian S

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Mechanism for Effective Lymphoid Cell and Tissue Loading Following Oral Administration of Nucleotide Prodrug GS-7340 von Babusis, Darius, Phan, Truc K, Lee, William A, Watkins, William J, Ray, Adrian S

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Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured hum... von Lepist, Eve-Irene, Gillies, Hunter, Smith, William, Hao, Jia, Hubert, Cassandra, St Claire, 3rd, Robert L, Brouwer, Kenneth R, Ray, Adrian S

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Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR‑2 (SLC19A3) von Liang, Xiaomin, Chien, Huan-Chieh, Yee, Sook Wah, Giacomini, Marilyn M, Chen, Eugene C, Piao, Meiling, Hao, Jia, Twelves, Jolyn, Lepist, Eve-Irene, Ray, Adrian S, Giacomini, Kathleen M

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Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus von Feng, Joy Y, Xu, Yili, Barauskas, Ona, Perry, Jason K, Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E, Sakowicz, Roman, Ray, Adrian S

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Mechanism of Active Renal Tubular Efflux of Tenofovir von RAY, Adrian S, CIHLAR, Tomas, ROBINSON, Kelly L, TONG, Leah, VELA, Jennifer E, FULLER, Michael D, WIEMAN, Lani M, EISENBERG, Eugene J, RHODES, Gerry R

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Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine von Cihlar, Tomas, Ray, Adrian S.

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Application of kinase bypass strategies to nucleoside antivirals von Ray, Adrian S., Hostetler, Karl Y.

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Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir von Wang, Ting, Babusis, Darius, Park, Yeojin, Niu, Congrong, Kim, Cynthia, Zhao, Xiaofeng, Lu, Bing, Ma, Bin, Muench, Robert C., Sperger, Diana, Ray, Adrian S., Murakami, Eisuke

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Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir von STRAY, Kirsten M, BAM, Rujuta A, BIRKUS, Gabriel, JIA HAO, LEPIST, Eve-Irene, YANT, Stephen R, RAY, Adrian S, CIHLAR, Tomas

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Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus von Ray, Adrian S., Fordyce, Marshall W., Hitchcock, Michael J.M.

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