Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses von Hilpert, Julia, Grosse-Hovest, Ludger, Grünebach, Frank, Buechele, Corina, Nuebling, Tina, Raum, Tobias, Steinle, Alexander, Salih, Helmut Rainer

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The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer von Deegen, Petra, Thomas, Oliver, Nolan-Stevaux, Olivier, Li, Shyun, Wahl, Joachim, Bogner, Pamela, Aeffner, Famke, Friedrich, Matthias, Liao, Michael Z., Matthes, Katja, Rau, Doris, Rattel, Benno, Raum, Tobias, Kufer, Peter, Coxon, Angela, Bailis, Julie M.

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Characterization of a Novel FLT3 BITE Molecule for the Treatment of Acute Myeloid Leukemia von Brauchle, Bettina, Goldstein, Rebecca L., Karbowski, Christine M., Henn, Anja, Li, Chi-Ming, Buecklein, Veit L., Krupka, Christina, Boyle, Michael C., Koppikar, Priya, Haubner, Sascha, Wahl, Joachim, Dahlhoff, Christoph, Raum, Tobias, Rardin, Matthew J., Sastri, Christine, Rock, Dan A., Von Bergwelt-Baildon, Michael, Frank, Brendon, Metzeler, Klaus H., Case, Ryan, Friedrich, Matthias, Balazs, Mercedesz, Spiekermann, Karsten, Coxon, Angela, Subklewe, Marion, Arvedson, Tara

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T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells von Lutterbuese, Ralf, Raum, Tobias, Kischel, Roman, Hoffmann, Patrick, Mangold, Susanne, Rattel, Benno, Friedrich, Matthias, Thomas, Oliver, Lorenczewski, Grit, Rau, Doris, Schaller, Evelyne, Herrmann, Ines, Wolf, Andreas, Urbig, Thomas, Baeuerle, Patrick A., Kufer, Peter, Ravetch, Jeffrey V.

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Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110 von Deisting, Wibke, Raum, Tobias, Kufer, Peter, Baeuerle, Patrick A, Münz, Markus

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Highly efficient elimination of colorectal tumor-initiating cells by an EpCAM/CD3-bispecific antibody engaging human T cells von Herrmann, Ines, Baeuerle, Patrick A, Friedrich, Matthias, Murr, Alexander, Filusch, Susanne, Rüttinger, Dominik, Majdoub, Mariam W, Sharma, Sherven, Kufer, Peter, Raum, Tobias, Münz, Markus

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Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies von Münz, Markus, Murr, Alexander, Kvesic, Majk, Rau, Doris, Mangold, Susanne, Pflanz, Stefan, Lumsden, John, Volkland, Jörg, Fagerberg, Jan, Riethmüller, Gert, Rüttinger, Dominik, Kufer, Peter, Baeuerle, Patrick A, Raum, Tobias

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In vitro and in vivo activity of MT201, a fully human monoclonal antibody for pancarcinoma treatment von Naundorf, Stefanie, Preithner, Susanne, Mayer, Petra, Lippold, Sandra, Wolf, Andreas, Hanakam, Frank, Fichtner, Iduna, Kufer, Peter, Raum, Tobias, Riethmüller, Gert, Baeuerle, Patrick A., Dreier, Torsten

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AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer von Giffin, Michael J., Cooke, Keegan, Lobenhofer, Edward K., Estrada, Juan, Zhan, Jinghui, Deegen, Petra, Thomas, Melissa, Murawsky, Christopher M., Werner, Jonathan, Liu, Siyuan, Lee, Fei, Homann, Oliver, Friedrich, Matthias, Pearson, Joshua T., Raum, Tobias, Yang, Yajing, Caenepeel, Sean, Stevens, Jennitte, Beltran, Pedro J., Canon, Jude, Coxon, Angela, Bailis, Julie M., Hughes, Paul E.

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Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia von Friedrich, Matthias, Henn, Anja, Raum, Tobias, Bajtus, Monika, Matthes, Katja, Hendrich, Larissa, Wahl, Joachim, Hoffmann, Patrick, Kischel, Roman, Kvesic, Majk, Slootstra, Jerry W, Baeuerle, Patrick A, Kufer, Peter, Rattel, Benno

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Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs von Brozy, Johannes, Schlaepfer, Erika, Mueller, Christina K S, Rochat, Mary-Aude, Rampini, Silvana K, Myburgh, Renier, Raum, Tobias, Kufer, Peter, Baeuerle, Patrick A, Muenz, Markus, Speck, Roberto F

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Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens von Friedrich, Matthias, Raum, Tobias, Lutterbuese, Ralf, Voelkel, Markus, Deegen, Petra, Rau, Doris, Kischel, Roman, Hoffmann, Patrick, Brandl, Christian, Schuhmacher, Joachim, Mueller, Peter, Finnern, Ricarda, Fuergut, Melanie, Zopf, Dieter, Slootstra, Jerry W, Baeuerle, Patrick A, Rattel, Benno, Kufer, Peter

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Human IgG1 antibodies antagonizing activating receptor NKG2D on natural killer cells von Steigerwald, Jutta, Raum, Tobias, Pflanz, Stefan, Cierpka, Ronny, Mangold, Susanne, Rau, Doris, Hoffmann, Patrick, Kvesic, Majk, Zube, Christina, Linnerbauer, Stefanie, Lumsden, John, Sriskandarajah, Mirnaalini, Kufer, Peter, Baeuerle, Patrick A., Volkland, Jörg

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Abstract 3364: Preclinical evaluation of BiTE®immune therapy targeting MUC17 or CLDN18.2 for gastric cancer von Bailis, Julie M., Lutterbuese, Petra, Thomas, Oliver, Locher, Kathrin, Harrold, John, Boyle, Michael, Wahl, Joachim, Li, Shyun, Sternjak, Alexander, Henn, Anja, Dahlhoff, Christoph, Naegele, Virginie, Rattel, Benno, Raum, Tobias, Coxon, Angela

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Preclinical evaluation of AMG 160, a next-generation bispecific T cell engager (BiTE) targeting the prostate-specific membrane antigen PSMA for metastatic castration-resistant pros... von Bailis, Julie, Deegen, Petra, Thomas, Oliver, Bogner, Pamela, Wahl, Joachim, Liao, Mike, Li, Shyun, Matthes, Katja, Nägele, Virginie, Rau, Doris, Rattel, Benno, Raum, Tobias, Kufer, Peter, Coxon, Angela

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Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection von Pendzialek, Jochen, Roose, Kenny, Smet, Anouk, Schepens, Bert, Kufer, Peter, Raum, Tobias, Baeuerle, Patrick A., Muenz, Markus, Saelens, Xavier, Fiers, Walter

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Abstract 3632: BiTE® antibody constructs for the treatment of SCLC von Giffin, Michael J., Lobenhofer, Ed K., Cooke, Keegan, Raum, Tobias, Stevens, Jennitte, Beltran, Pedro J., Coxon, Angela, Hughes, Paul E.

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Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs von Brozy, Johannes, Schlaepfer, Erika, Mueller, Christina K S, Rochat, Mary-Aude, Rampini, Silvana K, Myburgh, Renier, Raum, Tobias, Kufer, Peter, Baeuerle, Patrick A, Muenz, Markus, Speck, Roberto F

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Abstract 3630: Preclinical evaluation of a BiTE® antibody construct with extended half-life that targets the tumor differentiation marker mesothelin von Sternjak, Alexander, Lee, Fei, Wahl, Joachim, Rock, Dan, Thomas, Oliver, Stienen, Sabine, Lutterbuese, Ralf, Hoffmann, Patrick, Raum, Tobias, Kufer, Peter, Rattel, Benno, Coxon, Angela, Friedrich, Matthias, Bailis, Julie

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Evaluation of a FLT3 Bite® for Acute Myeloid Leukemia von Goldstein, Rebecca, Henn, Anja, Koppikar, Priya, Archibeque, Ivonne, Frank, Brendon, Balazs, Mercedesz, Dahlhoff, Christoph, Raum, Tobias, Li, Chi-Ming, Wahl, Joachim, Rock, Dan, Thomas, Oliver, Karbowski, Christine, Krupka, Christina, Subklewe, Marion, Coxon, Angela, Chapman-Arvedson, Tara

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