Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma von Scott, Milcah C, Temiz, Nuri A, Sarver, Anne E, LaRue, Rebecca S, Rathe, Susan K, Varshney, Jyotika, Wolf, Natalie K, Moriarity, Branden S, O'Brien, Timothy D, Spector, Logan G, Largaespada, David A, Modiano, Jaime F, Subramanian, Subbaya, Sarver, Aaron L

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A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis von Moriarity, Branden S, Otto, George M, Rahrmann, Eric P, Rathe, Susan K, Wolf, Natalie K, Weg, Madison T, Manlove, Luke A, LaRue, Rebecca S, Temiz, Nuri A, Molyneux, Sam D, Choi, Kwangmin, Holly, Kevin J, Sarver, Aaron L, Scott, Milcah C, Forster, Colleen L, Modiano, Jaime F, Khanna, Chand, Hewitt, Stephen M, Khokha, Rama, Yang, Yi, Gorlick, Richard, Dyer, Michael A, Largaespada, David A

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Proliferation and Self-Renewal Are Differentially Sensitive to NRASG12V Oncogene Levels in an Acute Myeloid Leukemia Cell Line von Kurata, Morito, Antony, Marie Lue, Noble-Orcutt, Klara E, Rathe, Susan K, Lee, Yoonkyu, Furuno, Hidehiro, Ishibashi, Sachiko, Ikeda, Masumi, Yamamoto, Kouhei, Kitagawa, Masanobu, Largaespada, David A, Sachs, Zohar

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PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma von Smeester, Branden A., Slipek, Nicholas J., Pomeroy, Emily J., Laoharawee, Kanut, Osum, Sara H., Larsson, Alex T., Williams, Kyle B., Stratton, Natalie, Yamamoto, Kenta, Peterson, Joseph J., Rathe, Susan K., Mills, Lauren J., Hudson, Wendy A., Crosby, Margaret R., Wang, Minjing, Rahrmann, Eric P., Moriarity, Branden S., Largaespada, David A.

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CD200 Checkpoint Reversal: A Novel Approach to Immunotherapy von Xiong, Zhengming, Mesias, Elisabet Ampudia, Pluhar, G. Elizabeth, Rathe, Susan K., Largaespada, David A., Sham, Yuk Y., Moertel, Christopher L., Olin, Michael R.

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Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas von Rathe, Susan K., Popescu, Flavia E., Johnson, James E., Watson, Adrienne L., Marko, Tracy A., Moriarity, Branden S., Ohlfest, John R., Largaespada, David A.

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Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML von Kurata, Morito, Rathe, Susan K., Bailey, Natashay J., Aumann, Natalie K., Jones, Justine M., Veldhuijzen, G. Willemijn, Moriarity, Branden S., Largaespada, David A.

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R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers von Conboy, Caitlin B., Velez-Reyes, German L., Rathe, Susan K., Abrahante, Juan E., Temiz, Nuri A., Burns, Michael B., Harris, Reuben S., Starr, Timothy K., Largaespada, David A.

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Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma von Smeester, Branden A., Draper, Garrett M., Slipek, Nicholas J., Larsson, Alex T., Stratton, Natalie, Pomeroy, Emily J., Becklin, Kelsie L., Yamamoto, Kenta, Williams, Kyle B., Laoharawee, Kanut, Peterson, Joseph J., Abrahante, Juan E., Rathe, Susan K., Mills, Lauren J., Crosby, Margaret R., Hudson, Wendy A., Rahrmann, Eric P., Largaespada, David A., Moriarity, Branden S.

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Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma von Rahrmann, Eric P, Wolf, Natalie K, Otto, George M, Heltemes-Harris, Lynn, Ramsey, Laura B, Shu, Jingmin, LaRue, Rebecca S, Linden, Michael A, Rathe, Susan K, Starr, Timothy K, Farrar, Michael A, Moriarity, Branden S, Largaespada, David A

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Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma von Marko, Tracy A., Shamsan, Ghaidan A., Edwards, Elizabeth N., Hazelton, Paige E., Rathe, Susan K., Cornax, Ingrid, Overn, Paula R., Varshney, Jyotika, Diessner, Brandon J., Moriarity, Branden S., O’Sullivan, M. Gerard, Odde, David J., Largaespada, David A.

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Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia von Rathe, Susan K., Moriarity, Branden S., Stoltenberg, Christopher B., Kurata, Morito, Aumann, Natalie K., Rahrmann, Eric P., Bailey, Natashay J., Melrose, Ellen G., Beckmann, Dominic A., Liska, Chase R., Largaespada, David A.

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Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development von Velez-Reyes, German L., Koes, Nicholas, Ryu, Ji Hae, Kaufmann, Gabriel, Berner, Mariah, Weg, Madison T., Wolf, Natalie K., Rathe, Susan K., Ratner, Nancy, Moriarity, Branden S., Largaespada, David A.

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Synthesis and antileukemic activities of C1–C10-modified parthenolide analogues von Kempema, Aaron M., Widen, John C., Hexum, Joseph K., Andrews, Timothy E., Wang, Dan, Rathe, Susan K., Meece, Frederick A., Noble, Klara E., Sachs, Zohar, Largaespada, David A., Harki, Daniel A.

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NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia von Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.

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MMuFLR: missense mutation and frameshift location reporter von Rathe, Susan K, Johnson, James E, Silverstein, Kevin A T, Erdmann, Jesse J, Watson, Adrienne L, Popescu, Flavia E, Ohlfest, John R, Largaespada, David A

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Transcriptomic analysis of gene signatures associated with sickle pain von Paul, Jinny A., Aich, Anupam, Abrahante, Juan E., Wang, Ying, LaRue, Rebecca S., Rathe, Susan K., Kalland, Krystina, Mittal, Aditya, Jha, Ritu, Peng, Fei, Largaespada, David A., Bagchi, Anindya, Gupta, Kalpna

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Abstract 2582: Dose-dependent NRASG12V -mediated signaling controls cell cycle progression and leukemogenic signaling in a CRISPR/Cas9-modified human AML cell line von Kurata, Morito, Antony, Marie L., Noble, Klara E., Rathe, Susan K., Hirakouchi, Haruka, Yamamoto, Kouhei, Kitagawa, Masanobu, Sachs, Zohar, Largaespada, David A.

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A Screen for Drugs Showing Specific Co-Resistance or Hyper-Sensitivity Upon the Acquisition of Ara-C Resistance In AML von Rathe, Susan K, Largaespada, David

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TAMI-28. DIFFERENTIAL MIGRATION MECHANICS AND IMMUNE RESPONSES OF GLIOMA SUBTYPES von Shamsan, Ghaidan, Liu, Chao, Braman, Brooke, Rathe, Susan, Sarver, Aaron, Ghaderi, Nima, McMahon, Mariah, Klank, Rebecca, Tschida, Barbara, McFarren, Joey, Sarkaria, Jann, Clark, H Brent, Rosenfeld, Steven, Largaespada, David, Odde, David

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