PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma von Atsaves, V, Tsesmetzis, N, Chioureas, D, Kis, L, Leventaki, V, Drakos, E, Panaretakis, T, Grander, D, Medeiros, L J, Young, K H, Rassidakis, G Z

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Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma von Drakos, E, Atsaves, V, Li, J, Leventaki, V, Andreeff, M, Medeiros, L J, Rassidakis, G Z

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Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair von Tian, L, Peng, G, Parant, J M, Leventaki, V, Drakos, E, Zhang, Q, Parker-Thornburg, J, Shackleford, T J, Dai, H, Lin, S-Y, Lozano, G, Rassidakis, G Z, Claret, F X

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Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21... von Drakos, E, Singh, R R, Rassidakis, G Z, Schlette, E, Li, J, Claret, F X, Ford, R J, Vega, F, Medeiros, L J

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The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53 von Drakos, E, Atsaves, V, Schlette, E, Li, J, Papanastasi, I, Rassidakis, G Z, Medeiros, L J

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p53 gene mutations are uncommon but p53 is commonly expressed in anaplastic large-cell lymphoma: Lymphoma von Rassidakis, G Z, Thomaides, A, Wang, S, Jiang, Y, Fourtouna, A, Lai, R, Medeiros, L J

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Constitutive control of AKT1 gene expression by JUNB/CJUN in ALK+ anaplastic large-cell lymphoma: a novel crosstalk mechanism von Atsaves, V, Zhang, R, Ruder, D, Pan, Y, Leventaki, V, Rassidakis, G Z, Claret, F X

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PB2171: THE NOVEL CSN5/JAB1 INHIBITOR CSN5I‐3 SUPPRESSES CELL GROWTH AND UPREGULATES GENE EXPRESSION OF TYPE‐I INTERFERONS (IFN) IN ANAPLASTIC LARGE CELL LYMPHOMA (ALCL) von Xagoraris, I., Kokaraki, G., Stathopoulou, K., Claret, F. X., Drakos, E., Rassidakis, G. Z.

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P1304: THE NOVEL TUMOR SUPPRESSOR SAMHD1 CONTRIBUTES TO ANTI‐TUMOR RESPONSES IN A CGAS‐STING‐DEPENDENT OR INDEPENDENT PATHWAY IN HODGKIN LYMPHOMA (HL) von Xagoraris, I., Kokaraki, G., Stathopoulou, K., Xyderou, P., Kurzay, A., Herold, N., Lundqvist, A., Rassidakis, G. Z.

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Trimetrexate in Relapsed T-Cell Lymphoma With Skin Involvement von SARRIS, A. H, PHAN, A, CABANILLAS, F, DUVIC, M, ROMAGUERA, J, MCLAUGHLIN, P, MESINA, O, KING, K, MEDEIROS, L. J, RASSIDAKIS, G. Z, SAMUELS, B

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Constitutive control of AKT1 gene expression by JUNB/CJUN in ALK plus anaplastic large-cell lymphoma: a novel crosstalk mechanism von Atsaves, V, Zhang, R, Ruder, D, Pan, Y, Leventaki, V, Rassidakis, GZ, Claret, FX

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Serum interleukin-10 levels are an independent prognostic factor for patients with Hodgkin's lymphoma von Vassilakopoulos, TP, Nadali, G, Angelopoulou, MK, Siakantaris, MP, Dimopoulou, MN, Kontopidou, FN, Rassidakis, GZ, Doussis-Anagnostopoulou, IA, Hatzioannou, M, Vaiopoulos, G, Kittas, C, Sarris, AH, Pizzolo, G, Pangalis, GA

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Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma: Lymphoma von Cho-Vega, J H, Rassidakis, G Z, Amin, H M, Tsioli, P, Spurgers, K, Remache, Y K, Vega, F, Goy, A H, Gilles, F, Jeffrey Medeiros, L

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Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations von Zerdes, Ioannis, Matikas, Alexios, Bergh, Jonas, Rassidakis, George Z., Foukakis, Theodoros

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Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma von Amin, Hesham M, Medeiros, L Jeffrey, Ma, Yupo, Feretzaki, Marianna, Das, Pamela, Leventaki, Vasiliki, Rassidakis, George Z, O'Connor, Sean L, McDonnell, Timothy J, Lai, Raymond

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A MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF THE MDM2 PROTEIN ISOFORMS AND p53 GENE PRODUCT IN BRONCHOGENIC CARCINOMA von GORGOULIS, VASSILIS G., ZOUMPOURLIS, VASSILIS, RASSIDAKIS, GEORGE Z., KARAMERIS, ANDREAS, RASSIDAKIS, ANTONIS N., SPANDIDOS, DEMETRIOS A., KITTAS, CHRISTOS

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AP-1 Transcription Factors as Regulators of Immune Responses in Cancer von Atsaves, Vasileios, Leventaki, Vasiliki, Rassidakis, George Z, Claret, Francois X

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Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene von Gorgoulis, VG, Zacharatos, PV, Manolis, E, Ikonomopoulos, JA, Damalas, A, Lamprinopoulos, C, Rassidakis, GZ, Zoumpourlis, V, Kotsinas, A, Rassidakis, AN, Halazonetis, TD, Kittas, C

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BCL-2 family proteins in peripheral T-cell lymphomas: correlation with tumour apoptosis and proliferation von Rassidakis, George Z, Jones, Dan, Lai, Raymond, Ramalingam, Preetha, Sarris, Andreas H, McDonnell, Timothy J, Jeffrey Medeiros, L

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Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression von Khoury, Joseph D, Medeiros, L Jeffrey, Rassidakis, George Z, McDonnell, Timothy J, Abruzzo, Lynne V, Lai, Raymond

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