Clinical development innovation in rare diseases: overcoming barriers to successful delivery of a randomised clinical trial in alkaptonuria-a mini-review von Ranganath, L R, Sireau, Nick

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Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria von Ranganath, L. R., Milan, A. M., Hughes, A. T., Davison, A. S., M, Khedr, Norman, B. P., Bou-Gharios, G., Gallagher, J. A., Imrich, R., Arnoux, J. B., Rudebeck, M., Olsson, B.

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The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria von Taylor, A. M., Boyde, A., Wilson, P. J. M., Jarvis, J. C., Davidson, J. S., Hunt, J. A., Ranganath, L. R., Gallagher, J. A.

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Anthropometric, Body Composition, and Nutritional Indicators with and without Nutritional Intervention during Nitisinone Therapy in Alkaptonuria von Ranganath, L R, Khedr, M, Milan, A M, Davison, A S, Hughes, A T, Norman, B P, Bygott, H, Luangrath, E, Judd, S, Soulsby, C, Olsson, B, Imrich, R

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Incretins: pathophysiological and therapeutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 von Ranganath, L R

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Alkaptonuria – Many questions answered, further challenges beckon von Davison, AS, Hughes, AT, Milan, AM, Sireau, N, Gallagher, JA, Ranganath, LR

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Inflammatory and oxidative stress biomarkers in alkaptonuria: data from the DevelopAKUre project von Braconi, D., Giustarini, D., Marzocchi, B., Peruzzi, L., Margollicci, M., Rossi, R., Bernardini, G., Millucci, L., Gallagher, J.A., Le Quan Sang, K.-H., Imrich, R., Rovensky, J., Al-Sbou, M., Ranganath, L.R., Santucci, A.

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The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women von Baines, M, Kredan, M.-B, Usher, J, Davison, A, Higgins, G, Taylor, W, West, C, Fraser, W.D, Ranganath, L.R

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Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone von Davison, A.S., Harrold, J.A., Hughes, G., Norman, B.P., Devine, J., Usher, J., Hughes, A.T., Khedr, M., Gallagher, J.A., Milan, A.M., J.C.G., Halford, Ranganath, L.R.

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Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal we... von Daousi, C., Wilding, J. P. H., Aditya, S., Durham, B. H., Cleator, J., Pinkney, J. H., Ranganath, L. R.

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Frequency, diagnosis, pathogenesis and management of osteoporosis in alkaptonuria: data analysis from the UK National Alkaptonuria Centre von Ranganath, L. R., Khedr, M., Vinjamuri, S., Gallagher, J. A.

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Attenuated GLP-1 secretion in obesity: cause or consequence? von Ranganath, L R, Beety, J M, Morgan, L M, Wright, J W, Howland, R, Marks, V

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Nitisinone arrests ochronosis and decreases rate of progression of Alkaptonuria: Evaluation of the effect of nitisinone in the United Kingdom National Alkaptonuria Centre von Ranganath, L.R., Khedr, M., Milan, A.M., Davison, A.S., Hughes, A.T., Usher, J.L., Taylor, S., Loftus, N., Daroszewska, A., West, E., Jones, A., Briggs, M., Fisher, M., McCormick, M., Judd, S., Vinjamuri, S., Griffin, R., Psarelli, E.E., Cox, T.F., Sireau, N., Dillon, J.P., Devine, J.M., Hughes, G., Harrold, J., Barton, G.J., Jarvis, J.C., Gallagher, J.A.

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Identification of trabecular excrescences, novel microanatomical structures, present in bone in osteoarthropathies von Taylor, A M, Boyde, A, Davidson, J S, Jarvis, J C, Ranganath, L R, Gallagher, J A

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Evaluating the aortic stenosis phenotype before and after the effect of homogentisic acid lowering therapy: Analysis of a large cohort of eighty-one alkaptonuria patients von Ranganath, L.R., Heseltine, T., Khedr, M., Fisher, M.F.

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Identifying joint-specific gait mechanisms causing impaired gait in alkaptonuria patients von Shepherd, H.R., Robinson, M.A., Ranganath, L.R., Barton, G.J.

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Calculi and intracellular ochronosis in the submandibular tissues from a patient with alkaptonuria von Taylor, A M, Wilson, P J M, Ingrams, D R, Helliwell, T R, Gallagher, J A, Ranganath, L R

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Hepatobiliary circulation and dominant urinary excretion of homogentisic acid in a mouse model of alkaptonuria von Norman, B. P., Sutherland, H., Wilson, P. J. M., Rutland, D. A., Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Jarvis, J. C., Gallagher, J. A., Bou‐Gharios, G., Ranganath, L. R.

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Urine homogentisic acid and tyrosine: Simultaneous analysis by liquid chromatography tandem mass spectrometry von Hughes, A.T., Milan, A.M., Christensen, P., Ross, G., Davison, A.S., Gallagher, J.A., Dutton, J.J., Ranganath, L.R.

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Raman Spectroscopy identifies differences in ochronotic and non-ochronotic cartilage; a potential novel technique for monitoring ochronosis von Taylor, A.M., Jenks, D.D., Kammath, V.D., Norman, B.P., Dillon, J.P., Gallagher, J.A., Ranganath, L.R., Kerns, J.G.

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