Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models von Sankaranarayanan, Sethu, Barten, Donna M, Vana, Laurel, Devidze, Nino, Yang, Ling, Cadelina, Gregory, Hoque, Nina, DeCarr, Lynn, Keenan, Stefanie, Lin, Alan, Cao, Yang, Snyder, Bradley, Zhang, Bin, Nitla, Magdalena, Hirschfeld, Gregg, Barrezueta, Nestor, Polson, Craig, Wes, Paul, Rangan, Vangipuram S, Cacace, Angela, Albright, Charles F, Meredith, Jr, Jere, Trojanowski, John Q, Lee, Virginia M-Y, Brunden, Kurt R, Ahlijanian, Michael

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Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab von Ramagopal, Udupi A., Liu, Weifeng, Garrett-Thomson, Sarah C., Bonanno, Jeffrey B., Yan, Qingrong, Srinivasan, Mohan, Wong, Susan C., Bell, Alasdair, Mankikar, Shilpa, Rangan, Vangipuram S., Deshpande, Shrikant, Korman, Alan J., Almo, Steven C.

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Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance von Nambiar, Dhanya K, Aguilera, Todd, Cao, Hongbin, Kwok, Shirley, Kong, Christina, Bloomstein, Joshua, Wang, Zemin, Rangan, Vangipuram S, Jiang, Dadi, von Eyben, Rie, Liang, Rachel, Agarwal, Sonya, Colevas, A Dimitrios, Korman, Alan, Allen, Clint T, Uppaluri, Ravindra, Koong, Albert C, Giaccia, Amato, Le, Quynh Thu

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Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies von Kotapati, Srikanth, Passmore, David, Yamazoe, Sayumi, Sanku, Rajesh Kishore Kumar, Cong, Qiang, Poudel, Yam B, Chowdari, Naidu S, Gangwar, Sanjeev, Rao, Chetana, Rangan, Vangipuram S, Cardarelli, Pina M, Deshpande, Shrikant, Strop, Pavel, Dollinger, Gavin, Rajpal, Arvind

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Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC–MS/MS approach: Assay development, validation, and a case study von Liu, Ang, Kozhich, Alexander, Passmore, David, Gu, Huidong, Wong, Richard, Zambito, Frank, Rangan, Vangipuram S., Myler, Heather, Aubry, Anne-Françoise, Arnold, Mark E., Wang, Jian

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A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines von Zhao, Qihong, Kim, Taeg, Pang, Jian, Sun, Wendy, Yang, Xiaoxia, Wang, Jinhong, Song, Yunling, Zhang, Hongwei, Sun, Huadong, Rangan, Vangipuram, Deshpande, Shrikant, Tang, Huaping, Cvijic, Mary Ellen, Westhouse, Richard, Olah, Timothy, Xie, Jenny, Struthers, Mary, Salter‐Cid, Luisa

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A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer von Ponath, Paul, Menezes, Daniel, Pan, Chin, Chen, Bing, Oyasu, Miho, Strachan, Debbie, LeBlanc, Heidi, Sun, Huadong, Wang, Xi-Tao, Rangan, Vangipuram S, Deshpande, Shrikant, Cristea, Sandra, Park, Kwon-Sik, Sage, Julien, Cardarelli, Pina M

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Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer d... von Huang, Richard Y.-C., Kuhne, Michelle, Deshpande, Shrikant, Rangan, Vangipuram, Srinivasan, Mohan, Wang, Yun, Chen, Guodong

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A novel semi‐mechanistic tumor growth fraction model for translation of preclinical efficacy of anti‐glypican 3 antibody drug conjugate to human von Singh, Renu, Kozhich, Alexander, Pan, Chin, Lee, Francis, Cardarelli, Pina, Vangipuram, Rangan, Iyer, Rama, Marathe, Punit

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Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates von Chowdari, Naidu S, Zhang, Yong, McDonald, Ivar, Johnson, Walter, Langley, David R, Sivaprakasam, Prasanna, Mate, Robert, Huynh, Tram, Kotapati, Srikanth, Deshpande, Madhura, Pan, Chin, Menezes, Daniel, Wang, Yichong, Rao, Chetana, Sarma, Ganapathy, Warrack, Bethanne M, Rangan, Vangipuram S, Mei-Chen, Sung, Cardarelli, Pina, Deshpande, Shrikant, Passmore, David, Rampulla, Richard, Mathur, Arvind, Borzilleri, Robert, Rajpal, Arvind, Vite, Gregory, Gangwar, Sanjeev

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Challenges in Antibody–Drug Conjugate Discovery: A Bioconjugation and Analytical Perspective von Rao, Chetana, Rangan, Vangipuram S, Deshpande, Shrikant

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Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy von Chowdari, Naidu S., Pan, Chin, Rao, Chetana, Langley, David R., Sivaprakasam, Prasanna, Sufi, Bilal, Derwin, Daniel, Wang, Yichong, Kwok, Eilene, Passmore, David, Rangan, Vangipuram S., Deshpande, Shrikant, Cardarelli, Pina, Vite, Gregory, Gangwar, Sanjeev

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Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans von Wang, Haiqing, Rangan, Vangipuram S., Sung, Mei-Chen, Passmore, David, Kempe, Thomas, Wang, Xiaoli, Thevanayagam, Lourdes, Pan, Chin, Rao, Chetana, Srinivasan, Mohan, Zhang, Qian, Gangwar, Sanjeev, Deshpande, Shrikant, Cardarelli, Pina, Marathe, Punit, Yang, Zheng

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Production of human monoclonal antibody in eggs of chimeric chickens von Etches, Robert J, Zhu, Lei, van de Lavoir, Marie-Cecile, Albanese, Jenny, Beenhouwer, David O, Cardarelli, Pina M, Cuison, Severino, Deng, David F, Deshpande, Shrikant, Diamond, Jennifer H, Green, Lynae, Halk, Edward L, Heyer, Babette S, Kay, Robert M, Kerchner, Allyn, Leighton, Philip A, Mather, Christine M, Morrison, Sherie L, Nikolov, Zivko L, Passmore, David B, Pradas-Monne, Alicia, Preston, Benjamin T, Rangan, Vangipuram S, Shi, Mingxia, Srinivasan, Mohan, White, Steven G, Winters-Digiacinto, Peggy, Wong, Susan, Zhou, Wen

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1064 Characterization of preclinical anti-tumor and pharmacodynamic activity in response to conditionally active IFNa with or without checkpoint blockade von Povinelli, Benjamin, Kaur, Kamaljeet, Berezhnoy, Alexey, Wang, Hsin, Lapuyade, Nicole, LePage, Carol, Winter, Michael, Vasiljeva, Olga, Paidhungat, Madan, Rangan, Vangipuram, Scolan, Erwan Le, Boustany, Leila, Belvin, Marcia, Daniel, Dylan

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Biotransformation and Stability of Antibody–Drug Conjugates: Payload Metabolism and Linker Cleavage Delineation von Rangan, Vangipuram S, Myler, Heather, Kozhich, Alexander, Wang, Jian, Randazzo, Renee, Deshpande, Shrikant

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An Integrated Multiplatform Bioanalytical Strategy for Antibody–Drug Conjugates: A Novel Case Study von Myler, Heather, Rangan, Vangipuram S, Wang, Jian, Kozhich, Alexander, Cummings, Jennifer A, Neely, Robert, Dail, Donna, Liu, Ang, Wang, Bonnie, Vezina, Heather E, Freebern, Wendy, Sung, Mei-Chen, Passmore, David, Deshpande, Shrikant, Kempe, Thomas, Gu, Huidong, Saewert, Mark, Manney, Amy, Lute, John, Zambito, Frank, Wong, Richard L, Piccoli, Steven P, Aubry, Anne-Françoise, Pillutla, Renuka, Arnold, Mark, DeSilva, Binodh

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Validation of an Integrated Series of Ligand-Binding Assays for The Quantitative Determination of Antibody–Drug Conjugates in Biological Matrices von Myler, Heather, Rangan, Vangipuram S, Kozhich, Alex, Hoffpauir, Brian, Dail, Donna, Cummings, Jennifer, Saewert, Mark, Manney, Amy, Liu, Ang, Rao, Chetana, Wang, Jian, Pillutla, Renuka, DeSilva, Binodh

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Cloning, Expression, and Characterization of a Human 4′-Phosphopantetheinyl Transferase with Broad Substrate Specificity von Joshi, Anil K., Zhang, Lei, Rangan, Vangipuram S., Smith, Stuart

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Mapping the Functional Topology of the Animal Fatty Acid Synthase by Mutant Complementation in Vitro von Rangan, Vangipuram S, Joshi, Anil K, Smith, Stuart

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