Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases von Ni, Jing, Ramkissoon, Shakti H, Xie, Shaozhen, Goel, Shom, Stover, Daniel G, Guo, Hanbing, Luu, Victor, Marco, Eugenio, Ramkissoon, Lori A, Kang, Yun Jee, Hayashi, Marika, Nguyen, Quang-De, Ligon, Azra H, Du, Rose, Claus, Elizabeth B, Alexander, Brian M, Yuan, Guo-Cheng, Wang, Zhigang C, Iglehart, J Dirk, Krop, Ian E, Roberts, Thomas M, Winer, Eric P, Lin, Nancy U, Ligon, Keith L, Zhao, Jean J

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Clinical management and genomic profiling of pediatric low-grade gliomas in Saudi Arabia von Mobark, Nahla A., Alharbi, Musa, Alhabeeb, Lamees, AlMubarak, Latifa, Alaljelaify, Rasha, AlSaeed, Mariam, Almutairi, Amal, Alqubaishi, Fatmah, Ahmad, Maqsood, Al-Banyan, Ayman, Alotabi, Fahad E., Barakeh, Duna, AlZahrani, Malak, Al-Khalidi, Hisham, Ajlan, Abdulrazag, Ramkissoon, Lori A., Ramkissoon, Shakti H., Abedalthagafi, Malak

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Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors von Ramkissoon, Lori A., Pegram, Worthy, Haberberger, James, Danziger, Natalie, Lesser, Glenn, Strowd, Roy, Dahiya, Sonika, Cummings, Thomas J., Bi, Wenya Linda, Abedalthagafi, Malak, Sathyan, Pratheesh, McGregor, Kimberly, Reddy, Prasanth, Severson, Eric, Williams, Erik, Lin, Douglas, Edgerly, Claire, Huang, Richard S. P., Hemmerich, Amanda, Creeden, James, Brown, Charlotte, Venstrom, Jeffrey, Hegde, Priti, Ross, Jeffrey S., Alexander, Brian M., Elvin, Julia, Ramkissoon, Shakti H.

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Applications of next-generation sequencing in hematologic malignancies von Ramkissoon, Lori A., Montgomery, Nathan D.

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A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas von Sun, Yu, Alberta, John A, Pilarz, Catherine, Calligaris, David, Chadwick, Emily J, Ramkissoon, Shakti H, Ramkissoon, Lori A, Garcia, Veronica Matia, Mazzola, Emanuele, Goumnerova, Liliana, Kane, Michael, Yao, Zhan, Kieran, Mark W, Ligon, Keith L, Hahn, William C, Garraway, Levi A, Rosen, Neal, Gray, Nathanael S, Agar, Nathalie Y, Buhrlage, Sara J, Segal, Rosalind A, Stiles, Charles D

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Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1 von Ramkissoon, Lori A., Horowitz, Peleg M., Craig, Justin M., Ramkissoon, Shakti H., Rich, Benjamin E., Schumacher, Steven E., McKenna, Aaron, Lawrence, Michael S., Bergthold, Guillaume, Brastianos, Priscilla K., Tabak, Barbara, Ducar, Matthew D., Van Hummelen, Paul, MacConaill, Laura E., Pouissant-Young, Tina, Cho, Yoon-Jae, Taha, Hala, Mahmoud, Madeha, Bowers, Daniel C., Margraf, Linda, Tabori, Uri, Hawkins, Cynthia, Packer, Roger J., Hill, D. Ashley, Pomeroy, Scott L., Eberhart, Charles G., Dunn, Ian F., Goumnerova, Liliana, Getz, Gad, Chan, Jennifer A., Santagata, Sandro, Hahn, William C., Stiles, Charles D., Ligon, Azra H., Kieran, Mark W., Beroukhim, Rameen, Ligon, Keith L.

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PIK3CA Mutation in HPV-Associated OPSCC Patients Receiving Deintensified Chemoradiation von Beaty, Brian T, Moon, Dominic H, Shen, Colette J, Amdur, Robert J, Weiss, Jared, Grilley-Olson, Juneko, Patel, Shetal, Zanation, Adam, Hackman, Trevor G, Thorp, Brian, Blumberg, Jeffrey M, Patel, Samip N, Weissler, Mark C, Yarbrough, Wendell G, Sheets, Nathan C, Parker, Joel S, Neil Hayes, D, Weck, Karen E, Ramkissoon, Lori A, Mendenhall, William M, Dagan, Roi, Tan, Xianming, Gupta, Gaorav P, Chera, Bhishamjit S

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Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors von Ramkissoon, Shakti H, Bandopadhayay, Pratiti, Hwang, Jaeho, Ramkissoon, Lori A, Greenwald, Noah F, Schumacher, Steven E, O'Rourke, Ryan, Pinches, Nathan, Ho, Patricia, Malkin, Hayley, Sinai, Claire, Filbin, Mariella, Plant, Ashley, Bi, Wenya Linda, Chang, Michael S, Yang, Edward, Wright, Karen D, Manley, Peter E, Ducar, Matthew, Alexandrescu, Sanda, Lidov, Hart, Delalle, Ivana, Goumnerova, Liliana C, Church, Alanna J, Janeway, Katherine A, Harris, Marian H, MacConaill, Laura E, Folkerth, Rebecca D, Lindeman, Neal I, Stiles, Charles D, Kieran, Mark W, Ligon, Azra H, Santagata, Sandro, Dubuc, Adrian M, Chi, Susan N, Beroukhim, Rameen, Ligon, Keith L

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A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors von Haberberger, James F, Pegram, Worthy, Britt, Nicholas, Schiavone, Kelsie, Severson, Eric, Sharaf, Radwa, Albacker, Lee A, Williams, Erik, Lechpammer, Mirna, Hemmerich, Amanda, Lin, Douglas, Huang, Richard S P, Hiemenz, Matthew, Elvin, Julia, Graf, Ryon, Lesser, Glenn, Kram, David, Strowd, Roy, Bi, Wenya Linda, Ramkissoon, Lori A, Cohen, Michael B, Reddy, Prasanth, Creeden, James, Ross, Jeffrey S, Alexander, Brian M, Ramkissoon, Shakti H

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Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma von Green, Adam L, Ramkissoon, Shakti H, McCauley, Dilara, Jones, Kristen, Perry, Jennifer A, Hsu, Jessie Hao-Ru, Ramkissoon, Lori A, Maire, Cecile L, Hubbell-Engler, Benjamin, Knoff, David S, Shacham, Sharon, Ligon, Keith L, Kung, Andrew L

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Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas von Cryan, Jane B, Haidar, Sam, Ramkissoon, Lori A, Bi, Wenya Linda, Knoff, David S, Schultz, Nikolaus, Abedalthagafi, Malak, Brown, Loreal, Wen, Patrick Y, Reardon, David A, Dunn, Ian F, Folkerth, Rebecca D, Santagata, Sandro, Lindeman, Neal I, Ligon, Azra H, Beroukhim, Rameen, Hornick, Jason L, Alexander, Brian M, Ligon, Keith L, Ramkissoon, Shakti H

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MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma von Miller, Michael B, Bi, Wenya Linda, Ramkissoon, Lori A, Kang, Yun Jee, Abedalthagafi, Malak, Knoff, David S, Agarwalla, Pankaj K, Wen, Patrick Y, Reardon, David A, Alexander, Brian M, Laws, Jr, Edward R, Dunn, Ian F, Beroukhim, Rameen, Ligon, Keith L, Ramkissoon, Shakti H

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Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma von Ramkissoon, Shakti H, Bi, Wenya Linda, Schumacher, Steven E, Ramkissoon, Lori A, Haidar, Sam, Knoff, David, Dubuc, Adrian, Brown, Loreal, Burns, Margot, Cryan, Jane B, Abedalthagafi, Malak, Kang, Yun Jee, Schultz, Nikolaus, Reardon, David A, Lee, Eudocia Q, Rinne, Mikael L, Norden, Andrew D, Nayak, Lakshmi, Ruland, Sandra, Doherty, Lisa M, LaFrankie, Debra C, Horvath, Margaret, Aizer, Ayal A, Russo, Andrea, Arvold, Nils D, Claus, Elizabeth B, Al-Mefty, Ossama, Johnson, Mark D, Golby, Alexandra J, Dunn, Ian F, Chiocca, E Antonio, Trippa, Lorenzo, Santagata, Sandro, Folkerth, Rebecca D, Kantoff, Philip, Rollins, Barrett J, Lindeman, Neal I, Wen, Patrick Y, Ligon, Azra H, Beroukhim, Rameen, Alexander, Brian M, Ligon, Keith L

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Precision Neuro-oncology: the Role of Genomic Testing in the Management of Adult and Pediatric Gliomas von Ramkissoon, Lori A., Britt, Nicholas, Guevara, Alexander, Whitt, Emily, Severson, Eric, Sathyan, Pratheesh, Gay, Laurie, Elvin, Julia, Ross, Jeffrey S., Brown, Charlotte, Stogner-Underwood, Kimberly, Mott, Ryan, Kram, David, Strowd, Roy, Lesser, Glenn J., Ramkissoon, Shakti H.

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Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma von Fontebasso, Adam M, Papillon-Cavanagh, Simon, Schwartzentruber, Jeremy, Nikbakht, Hamid, Gerges, Noha, Fiset, Pierre-Olivier, Bechet, Denise, Faury, Damien, De Jay, Nicolas, Ramkissoon, Lori A, Corcoran, Aoife, Jones, David T W, Sturm, Dominik, Johann, Pascal, Tomita, Tadanori, Goldman, Stewart, Nagib, Mahmoud, Bendel, Anne, Goumnerova, Liliana, Bowers, Daniel C, Leonard, Jeffrey R, Rubin, Joshua B, Alden, Tord, Browd, Samuel, Geyer, J Russell, Leary, Sarah, Jallo, George, Cohen, Kenneth, Gupta, Nalin, Prados, Michael D, Carret, Anne-Sophie, Ellezam, Benjamin, Crevier, Louis, Klekner, Almos, Bognar, Laszlo, Hauser, Peter, Garami, Miklos, Myseros, John, Dong, Zhifeng, Siegel, Peter M, Malkin, Hayley, Ligon, Azra H, Albrecht, Steffen, Pfister, Stefan M, Ligon, Keith L, Majewski, Jacek, Jabado, Nada, Kieran, Mark W

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MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism von Bandopadhayay, Pratiti, Ramkissoon, Lori A, Jain, Payal, Bergthold, Guillaume, Wala, Jeremiah, Zeid, Rhamy, Schumacher, Steven E, Urbanski, Laura, O'Rourke, Ryan, Gibson, William J, Pelton, Kristine, Ramkissoon, Shakti H, Han, Harry J, Zhu, Yuankun, Choudhari, Namrata, Silva, Amanda, Boucher, Katie, Henn, Rosemary E, Kang, Yun Jee, Knoff, David, Paolella, Brenton R, Gladden-Young, Adrianne, Varlet, Pascale, Pages, Melanie, Horowitz, Peleg M, Federation, Alexander, Malkin, Hayley, Tracy, Adam A, Seepo, Sara, Ducar, Matthew, Van Hummelen, Paul, Santi, Mariarita, Buccoliero, Anna Maria, Scagnet, Mirko, Bowers, Daniel C, Giannini, Caterina, Puget, Stephanie, Hawkins, Cynthia, Tabori, Uri, Klekner, Almos, Bognar, Laszlo, Burger, Peter C, Eberhart, Charles, Rodriguez, Fausto J, Hill, D Ashley, Mueller, Sabine, Haas-Kogan, Daphne A, Phillips, Joanna J, Santagata, Sandro, Stiles, Charles D, Bradner, James E, Jabado, Nada, Goren, Alon, Grill, Jacques, Ligon, Azra H, Goumnerova, Liliana, Waanders, Angela J, Storm, Phillip B, Kieran, Mark W, Ligon, Keith L, Beroukhim, Rameen, Resnick, Adam C

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Integrative Copy Number and Mutational Analysis Improves Glioma Diagnostics von Ramkissoon, Shakti H, Bi, Wenya L, Schumacher, Steven E, Ramkissoon, Lori A, Haidar, Sam, Dubuc, Adrian M, Brown, Loreal, Burns, Margot, Cryan, Jane, Reardon, David A, Lee, Eudocia Q, Rinne, Mikael L, Norden, Andrew D, Nayak, Lakshmi, Ruland, Sandra, Doherty, Lisa M, LaFrankie, Debra C, Russo, Andrea, Arvold, Nils D, Claus, Elizabeth B, Al-Mefty, Ossama, Johnson, Mark D, Golby, Alexandra, Dunn, Ian F, Chiocca, E. Antonio, Santagata, Sandro, Folkerth, Rebecca D, Kantoff, Philip, Rollins, Barrett J, Lindeman, Neal I, Wen, Patrick Y, Beroukhim, Rameen, Ligon, Azra H, Alexander, Brian M, Ligon, Keith L

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46. Recurrent 16p13.11 Microduplications: A retrospective review of 16 cases identified at the University of North Carolina von Sneddon, Tam P., Pendleton, Ashley B., Martin, Evan D., Ramkissoon, Lori A., Kaiser-Rogers, Kathleen A.

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LGG-01. CLINICAL MANAGEMENT AND GENOMIC PROFILING OF PEDIATRIC LOW-GRADE GLIOMAS IN SAUDI ARABIA von Mobark, Nahla A, Alharbi, Musa, Balbaid, Ali Abdullah O, Al-Habeeb, Lamees, AlMubarak, Latifa, Alaljelaify, Rasha, AlSaeed, Mariam, Almutairi, Amal, Alanazi, Fatmah A, Bashawri, Yara, Ahmad, Maqsood, Al-Banyan, Ayman, Alotabi, Fahad E, Barakeh, Duna, AlZahrani, Malak, Al-Khalidi, Hisham, Ajlan, Abdulrazag, Ramkissoon, Lori A, Ramkissoon, Shakti H, Abedalthagafi, Malak

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Abstract B077: Comprehensive molecular characterization and high-throughput chemical screening identifies genetic dependencies and molecular vulnerabilities in glioblastoma cell li... von Ferrer-Luna, Ruben, Ramkissoon, Shakti H., Ramkissoon, Lori A., Pellton, Kristine, Schumacher, Steven E., Lamothe, Rebecca, Cheah, Jaime H., Haidar, Sam, Kang, Yun J., Knoff, David S., Maire, Cecile L., Olausson, Karl H., Song, Wenyu, Idbaih, Ahmed, Rinne, Mikael L., Reardon, David A., Wen, Patrick Y., Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan J., Beroukhim, Rameen, Ligon, Keith L.

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