Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4 von Gajendran, Chandru, Fukui, Shoichi, Sadhu, Naveen M., Zainuddin, Mohammed, Rajagopal, Sridharan, Gosu, Ramachandraiah, Gutch, Sarah, Fukui, Saeko, Sheehy, Casey E., Chu, Long, Vishwakarma, Santosh, Jeyaraj, D. A., Hallur, Gurulingappa, Wagner, Denisa D., Sivanandhan, Dhanalakshmi

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A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression von Deng, Hui, Lin, Cindy, Garcia-Gerique, Laura, Fu, Shuyu, Cruz, Zachary, Bonner, Erin E, Rosenwasser, Matthew, Rajagopal, Sridharan, Sadhu, M Naveen, Gajendran, Chandru, Zainuddin, Mohd, Gosu, Ramachandraiah, Sivanandhan, Dhanalakshmi, Shelef, Miriam A, Nam, Brian, Vogl, Dan T, Gabrilovich, Dmitry I, Nefedova, Yulia

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A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders von Kannt, Aimo, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Swaminathan, Srinivasan, Hallur, Mahanandeesha Siddappa, Kristam, Rajendra, Elvert, Ralf, Czech, Jörg, Pfenninger, Anja, Rudolph, Christine, Schreuder, Herman, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Birudukota, Swarnakumari, Shaik, Shama, Zope, Bharat Ravindra, Burri, Raghunadha Reddy, Anand, Niranjan Naranapura, Thakur, Manish Kumar, Singh, Manvi, Parveen, Reejuana, Kandan, Saravanan, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Ruf, Sven, Dhakshinamoorthy, Saravanakumar

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Abstract B029: LSD1-HDAC6 dual inhibitor JBI-802 is an epigenetic modulating agent with a novel mechanism of action that target MYC amplification in multiple neuroendocrine tumor t... von Sivanandhan, Dhanalakshmi, Rajagopal, Sridharan, Gajendran, Chandru, Sadhu, Naveen, Zainuddin, Mohd, Gosu, Ramachandraiah, Rastelli, Luca

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Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution von Thakur, Manish Kumar, Birudukota, Swarnakumari, Swaminathan, Srinivasan, Battula, Sivarama Krishna, Vadivelu, Sarvanan, Tyagi, Rajiv, Gosu, Ramachandraiah

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Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution von Thakur, Manish Kumar, Kumar, Amit, Birudukota, Swarnakumari, Swaminathan, Srinivasan, Tyagi, Rajiv, Gosu, Ramachandraiah

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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase von Ruf, Sven, Hallur, Mahanandeesha Siddappa, Anchan, Nisha K., Swamy, Indu N., Murugesan, Karthikai Raj, Sarkar, Sayantani, Narasimhulu, Lokesh Kananti, Putta, V.P. Rama Kishore, Shaik, Shama, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Singh, Manvi, Burri, Raghunadha Reddy, Kristam, Rajendra, Schreuder, Herman, Czech, Joerg, Rudolph, Christine, Marker, Alexander, Langer, Thomas, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Kannt, Aimo, Dhakshinamoorthy, Saravanakumar, Rajagopal, Sridharan

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Abstract 6269: JBI-778, a novel brain-penetrant small molecule PRMT5 inhibitor for treatment of cancer von Sivanandhan, Dhanalakshmi, Gajendran, Chandru, M, Naveen Sadhu, Mohammed, Zainuddin, Gosu, Ramachandraiah, Sher, Divsha, Mansur, Shahar, Friedmann-Morvinski, Dinorah, Rajagopal, Sridharan, Rastelli, Luca

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Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide von Swaminathan, Srinivasan, Birudukota, Swarnakumari, Thakur, Manish Kumar, Parveen, Reejuana, Kandan, Saravanan, Juluri, Suresh, Shaik, Shama, Anand, Niranjan Naranapura, Burri, Raghunadha Reddy, Kristam, Rajendra, Hallur, Mahanandeesha Siddappa, Rajagopal, Sridharan, Schreuder, Herman, Langer, Thomas, Rudolph, Christine, Ruf, Sven, Dhakshinamoorthy, Saravanakumar, Gosu, Ramachandraiah, Kannt, Aimo

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Abstract 5552: Novel, heterocyclic small molecule inhibitors of PD-1 and PD-L1 pathway von Dhanalakshmi, Sivanandhan, Garapaty, Shivani, Venkateshappa, Chandregowda, Seerapu, Guru Pavan, Das, Reshma, Nagaraj, Pradeep, Kar, Ronodip, Singh, Anuj Kumar, Venkatesubbiah, Venkatesha Ashokkumar, Putta, Ramakishore VP, Pendyala, Muralidhar, Lokesh, Girisha, Madaka, Hari, Thummuru, Harikrishna Reddy, AP, Shikas, Anchan, Prateeksha, Bhat, Prathima, G, Rudresha, Zainuddin, Mohd, V, Krishnakumar, Gosu, Ramachandraiah, Kristam, Rajendra, DA, Jeyaraj, Rajagopal, Sriram

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The structure of XIAP BIR2: understanding the selectivity of the BIR domains von Lukacs, Christine, Belunis, Charles, Crowther, Robert, Danho, Waleed, Gao, Lin, Goggin, Barry, Janson, Cheryl A., Li, Shirley, Remiszewski, Stacy, Schutt, Andrew, Thakur, Manish K., Singh, Saroj K., Swaminathan, Srinivasan, Pandey, Rajat, Tyagi, Rajiv, Gosu, Ramachandraiah, Kamath, Ajith V., Kuglstatter, Andreas

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Abstract 3509: Novel dual inhibitors of LSD1-HDAC for treatment of cancer von Sivanandhan, Dhanalakshmi, Rajagopalan, Sridharan, Nair, Sreekala, Dewang, Purushottam, Kumar, Durga Prasanna, Mulakala, Chandrika, Mahadevan, Lavanya, Skariah, Neema, Kavuru, Venkata Giri, Kuntrapaku, Damodara, Sajja, Suchitra, Zainuddin, Mohammad, V, Krishnakumar, Singh, Ritu, V, Swarnakumari, Gosu, Ramachandraiah, Aiyar, Jayashree, Iyer, Pravin, Rajagopal, Sriram

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Sequence and structural determinants of mannose recognition von Ramachandraiah, Gosu, Chandra, Nagasuma R.

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Computational analysis of multivalency in lectins: structures of garlic lectin–oligosaccharide complexes and their aggregates von Ramachandraiah, Gosu, Chandra, Nagasuma R., Surolia, A., Vijayan, M.

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