Deciphering CAD: Structure and function of a mega‐enzymatic pyrimidine factory in health and disease von Caño‐Ochoa, Francisco, Ramón‐Maiques, Santiago

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Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase von Bellin, Leo, Del Caño-Ochoa, Francisco, Velázquez-Campoy, Adrián, Möhlmann, Torsten, Ramón-Maiques, Santiago

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A functional platform for the selection of pathogenic variants of PMM2 amenable to rescue via the use of pharmacological chaperones von Segovia‐Falquina, Cristina, Vilas, Alicia, Leal, Fátima, Caño‐Ochoa, Francisco, Kirk, Edwin P., Ugarte, Magdalena, Ramón‐Maiques, Santiago, Gámez, Alejandra, Pérez, Belén

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Insight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures von Briso‐Montiano, Alvaro, Del Caño‐Ochoa, Francisco, Vilas, Alicia, Velázquez‐Campoy, Adrián, Rubio, Vicente, Pérez, Belén, Ramón‐Maiques, Santiago

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A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD von Del Caño-Ochoa, Francisco, Rubio-Del-Campo, Antonio, Ramón-Maiques, Santiago

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Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD von del Caño-Ochoa, Francisco, Grande-García, Araceli, Reverte-López, María, D’Abramo, Marco, Ramón-Maiques, Santiago

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plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2 von Ramón-Maiques, Santiago, Kuo, Alex J, Carney, Dylan, Matthews, Adam G.W, Oettinger, Marjorie A, Gozani, Or, Yang, Wei

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MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition von Mizuno, Naoko, Dramićanin, Marija, Mizuuchi, Michiyo, Adam, Julia, Wang, Yi, Han, Yong-Woon, Yang, Wei, Steven, Alasdair C, Mizuuchi, Kiyoshi, Ramón-Maiques, Santiago

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Phosphorylation of T897 in the dimerization domain of Gemin5 modulates protein interactions and translation regulation von Francisco-Velilla, Rosario, Embarc-Buh, Azman, Abellan, Salvador, del Caño-Ochoa, Francisco, Ramón-Maiques, Santiago, Martinez-Salas, Encarnacion

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The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers von Lallous, Nada, Legrand, Pierre, McEwen, Alastair G, Ramón-Maiques, Santiago, Samama, Jean-Pierre, Birck, Catherine

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Structure and mechanism of human DNA polymerase η von Biertümpfel, Christian, Zhao, Ye, Kondo, Yuji, Ramón-Maiques, Santiago, Gregory, Mark, Lee, Jae Young, Masutani, Chikahide, Lehmann, Alan R., Hanaoka, Fumio, Yang, Wei

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Disruption of CAD Oligomerization by Pathogenic Variants von Del Caño-Ochoa, Francisco, Ramadane-Morchadi, Lobna, Eixerés, Lluís, Moreno-Morcillo, María, Fernández-Leiro, Rafael, Ramón-Maiques, Santiago

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Structure, Functional Characterization, and Evolution of the Dihydroorotase Domain of Human CAD von Grande-García, Araceli, Lallous, Nada, Díaz-Tejada, Celsa, Ramón-Maiques, Santiago

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Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation control von Moreno-Morcillo, María, Francisco-Velilla, Rosario, Embarc-Buh, Azman, Fernández-Chamorro, Javier, Ramón-Maiques, Santiago, Martinez-Salas, Encarnacion

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Significance of utilizing in silico structural analysis and phenotypic data to characterize phenylalanine hydroxylase variants: A PAH landscape von Himmelreich, Nastassja, Ramón-Maiques, Santiago, Navarrete, Rosa, Castejon-Fernandez, Natalia, Garbade, Sven F., Martinez, Aurora, Desviat, Lourdes R., Pérez, Belén, Blau, Nenad

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Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis von Moreno-Morcillo, María, Grande-García, Araceli, Ruiz-Ramos, Alba, del Caño-Ochoa, Francisco, Boskovic, Jasminka, Ramón-Maiques, Santiago

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Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA von Ruiz-Ramos, Alba, Velázquez-Campoy, Adrián, Grande-García, Araceli, Moreno-Morcillo, María, Ramón-Maiques, Santiago

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Two Crystal Structures of Escherichia coli N-Acetyl-l-Glutamate Kinase Demonstrate the Cycling between Open and Closed Conformations von Gil-Ortiz, Fernando, Ramón-Maiques, Santiago, Fernández-Murga, María L., Fita, Ignacio, Rubio, Vicente

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Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD von Ruiz-Ramos, Alba, Lallous, Nada, Grande-García, Araceli, Ramón-Maiques, Santiago

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Biallelic hypomorphic variants in CAD cause uridine-responsive macrocytic anaemia with elevated haemoglobin-A2 von Steinberg-Shemer, Orna, Yacobovich, Joanne, Noy-Lotan, Sharon, Dgany, Orly, Krasnov, Tanya, Barg, Assaf, Landau, Yuval E, Kneller, Katya, Somech, Raz, Gilad, Oded, Brik Simon, Dafna, Orenstein, Naama, Izraeli, Shai, Del Caño-Ochoa, Francisco, Tamary, Hannah, Ramón-Maiques, Santiago

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