Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo von Tiedt, Ralph, Schomber, Tibor, Hao-Shen, Hui, Skoda, Radek C.

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Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice von Tiedt, Ralph, Hao-Shen, Hui, Sobas, Marta A., Looser, Renate, Dirnhofer, Stephan, Schwaller, Jürg, Skoda, Radek C.

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Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf−/− mouse model von Chapeau, Emilie A., Gembarska, Agnieszka, Durand, Eric Y., Mandon, Emeline, Estadieu, Claire, Romanet, Vincent, Wiesmann, Marion, Tiedt, Ralph, Lehar, Joseph, deWeck, Antoine, Rad, Roland, Barys, Louise, Jeay, Sebastien, Ferretti, Stephane, Kauffmann, Audrey, Sutter, Esther, Grevot, Armelle, Moulin, Pierre, Murakami, Masato, Sellers, William R., Hofmann, Francesco, Jensen, Michael Rugaard

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Talin is required for integrin-mediated platelet function in hemostasis and thrombosis von Petrich, Brian G, Marchese, Patrizia, Ruggeri, Zaverio M, Spiess, Saskia, Weichert, Rachel A M, Ye, Feng, Tiedt, Ralph, Skoda, Radek C, Monkley, Susan J, Critchley, David R, Ginsberg, Mark H

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Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion von Léon, Catherine, Eckly, Anita, Hechler, Béatrice, Aleil, Boris, Freund, Monique, Ravanat, Catherine, Jourdain, Marie, Nonne, Christelle, Weber, Josiane, Tiedt, Ralph, Gratacap, Marie-Pierre, Severin, Sonia, Cazenave, Jean-Pierre, Lanza, François, Skoda, Radek, Gachet, Christian

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Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach von Chen, Chao, Zhu, Hugh, Stauffer, Frédéric, Caravatti, Giorgio, Vollmer, Susanne, Machauer, Rainer, Holzer, Philipp, Möbitz, Henrik, Scheufler, Clemens, Klumpp, Martin, Tiedt, Ralph, Beyer, Kim S, Calkins, Keith, Guthy, Daniel, Kiffe, Michael, Zhang, Jeff, Gaul, Christoph

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Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket von Scheufler, Clemens, Möbitz, Henrik, Gaul, Christoph, Ragot, Christian, Be, Céline, Fernández, César, Beyer, Kim S, Tiedt, Ralph, Stauffer, Frédéric

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A phase II study of the efficacy and safety of the MET inhibitor capmatinib (INC280) in patients with advanced hepatocellular carcinoma von Qin, Shukui, Chan, Stephen Lam, Sukeepaisarnjaroen, Wattana, Han, Guohong, Choo, Su Pin, Sriuranpong, Virote, Pan, Hongming, Yau, Thomas, Guo, Yabing, Chen, Minshan, Ren, Zhenggang, Xu, Jianming, Yen, Chia-Jui, Lin, Zhong-Zhe, Manenti, Luigi, Gu, Yi, Sun, Yongjian, Tiedt, Ralph, Hao, Lu, Song, Wenjie, Tanwandee, Tawesak

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Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach von Möbitz, Henrik, Machauer, Rainer, Holzer, Philipp, Vaupel, Andrea, Stauffer, Frédéric, Ragot, Christian, Caravatti, Giorgio, Scheufler, Clemens, Fernandez, Cesar, Hommel, Ulrich, Tiedt, Ralph, Beyer, Kim S, Chen, Chao, Zhu, Hugh, Gaul, Christoph

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Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition von Fassl, Anne, Brain, Christopher, Abu-Remaileh, Monther, Stukan, Iga, Butter, Deborah, Stepien, Piotr, Feit, Avery S, Bergholz, Johann, Michowski, Wojciech, Otto, Tobias, Sheng, Qing, Loo, Alice, Michael, Walter, Tiedt, Ralph, DeAngelis, Carmine, Schiff, Rachel, Jiang, Baishan, Jovanovic, Bojana, Nowak, Karolina, Ericsson, Maria, Cameron, Michael, Gray, Nathanael, Dillon, Deborah, Zhao, Jean J, Sabatini, David M, Jeselsohn, Rinath, Brown, Myles, Polyak, Kornelia, Sicinski, Piotr

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DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway von Dafflon, Caroline, Gaulis, Swann, Barys, Louise, Kapur, Karen, Cornacchione, Vanessa, Schukur, Lina, Bergling, Sebastian, Traggiai, Elisabetta, Jansky, Selina, Hellmann, Leon, Engstler, Barbara Schacher, Kerr, Grainne, de Weck, Antoine, Ruddy, David A, Naumann, Ulrike, Stauffer, Frédéric, Gaul, Christoph, Lin, Ying, Billy, Eric, Weiss, Andreas, Hofmann, Francesco, Ito, Moriko, Tiedt, Ralph

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A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression von Chapeau, Emilie A, Mandon, Emeline, Gill, Jason, Romanet, Vincent, Ebel, Nicolas, Powajbo, Violetta, Andraos-Rey, Rita, Qian, Zhiyan, Kininis, Miltos, Zumstein-Mecker, Sabine, Ito, Moriko, Hynes, Nancy E, Tiedt, Ralph, Hofmann, Francesco, Eshkind, Leonid, Bockamp, Ernesto, Kinzel, Bernd, Mueller, Matthias, Murakami, Masato, Baffert, Fabienne, Radimerski, Thomas

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A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family von Liu, Kun, Kralovics, Robert, Rudzki, Zbigniew, Grabowska, Barbara, Buser, Andreas S, Olcaydu, Damla, Gisslinger, Heinz, Tiedt, Ralph, Frank, Patricia, Okon, Krzysztof, van der Maas, Anthonie P.C, Skoda, Radek C

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Zim17, a Novel Zinc Finger Protein Essential for Protein Import into Mitochondria von Burri, Lena, Vascotto, Katherine, Fredersdorf, Steffen, Tiedt, Ralph, Hall, Michael N., Lithgow, Trevor

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening von McDonald, E. Robert, de Weck, Antoine, Schlabach, Michael R., Billy, Eric, Mavrakis, Konstantinos J., Hoffman, Gregory R., Belur, Dhiren, Castelletti, Deborah, Frias, Elizabeth, Gampa, Kalyani, Golji, Javad, Kao, Iris, Li, Li, Megel, Philippe, Perkins, Thomas A., Ramadan, Nadire, Ruddy, David A., Silver, Serena J., Sovath, Sosathya, Stump, Mark, Weber, Odile, Widmer, Roland, Yu, Jianjun, Yu, Kristine, Yue, Yingzi, Abramowski, Dorothee, Ackley, Elizabeth, Barrett, Rosemary, Berger, Joel, Bernard, Julie L., Billig, Rebecca, Brachmann, Saskia M., Buxton, Frank, Caothien, Roger, Caushi, Justina X., Chung, Franklin S., Cortés-Cros, Marta, deBeaumont, Rosalie S., Delaunay, Clara, Desplat, Aurore, Duong, William, Dwoske, Donald A., Eldridge, Richard S., Farsidjani, Ali, Feng, Fei, Feng, JiaJia, Flemming, Daisy, Forrester, William, Galli, Giorgio G., Gao, Zhenhai, Gauter, François, Gibaja, Veronica, Haas, Kristy, Hattenberger, Marc, Hood, Tami, Hurov, Kristen E., Jagani, Zainab, Jenal, Mathias, Johnson, Jennifer A., Jones, Michael D., Kapoor, Avnish, Korn, Joshua, Liu, Jilin, Liu, Qiumei, Liu, Shumei, Liu, Yue, Loo, Alice T., Macchi, Kaitlin J., Martin, Typhaine, McAllister, Gregory, Meyer, Amandine, Mollé, Sandra, Pagliarini, Raymond A., Phadke, Tanushree, Repko, Brian, Schouwey, Tanja, Shanahan, Frances, Shen, Qiong, Stamm, Christelle, Stephan, Christine, Stucke, Volker M., Tiedt, Ralph, Varadarajan, Malini, Venkatesan, Kavitha, Vitari, Alberto C., Wallroth, Marco, Weiler, Jan, Zhang, Jing, Mickanin, Craig, Myer, Vic E., Porter, Jeffery A., Lai, Albert, Bitter, Hans, Lees, Emma, Keen, Nicholas, Kauffmann, Audrey, Stegmeier, Frank, Hofmann, Francesco, Schmelzle, Tobias, Sellers, William R.

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Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation von Baltschukat, Sabrina, Engstler, Barbara Schacher, Huang, Alan, Hao, Huai-Xiang, Tam, Angela, Wang, Hui Qin, Liang, Jinsheng, DiMare, Matthew T, Bhang, Hyo-Eun Carrie, Wang, Youzhen, Furet, Pascal, Sellers, William R, Hofmann, Francesco, Schoepfer, Joseph, Tiedt, Ralph

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A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders von Kralovics, Robert, Passamonti, Francesco, Buser, Andreas S, Teo, Soon-Siong, Tiedt, Ralph, Passweg, Jakob R, Tichelli, Andre, Cazzola, Mario, Skoda, Radek C

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Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma von Goyal, Lipika, Saha, Supriya K, Liu, Leah Y, Siravegna, Giulia, Leshchiner, Ignaty, Ahronian, Leanne G, Lennerz, Jochen K, Vu, Phuong, Deshpande, Vikram, Kambadakone, Avinash, Mussolin, Benedetta, Reyes, Stephanie, Henderson, Laura, Sun, Jiaoyuan Elisabeth, Van Seventer, Emily E, Gurski, Jr, Joseph M, Baltschukat, Sabrina, Schacher-Engstler, Barbara, Barys, Louise, Stamm, Christelle, Furet, Pascal, Ryan, David P, Stone, James R, Iafrate, A John, Getz, Gad, Porta, Diana Graus, Tiedt, Ralph, Bardelli, Alberto, Juric, Dejan, Corcoran, Ryan B, Bardeesy, Nabeel, Zhu, Andrew X

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Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts von Perner, Florian, Gadrey, Jayant Y., Xiong, Yijun, Hatton, Charles, Eschle, Benjamin K., Weiss, Andreas, Stauffer, Frédéric, Gaul, Christoph, Tiedt, Ralph, Perry, Jennifer A., Armstrong, Scott A., Krivtsov, Andrei V.

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Phase Ib Study of Ribociclib plus Fulvestrant and Ribociclib plus Fulvestrant plus PI3K Inhibitor (Alpelisib or Buparlisib) for HR + Advanced Breast Cancer von Tolaney, Sara M, Im, Young-Hyuck, Calvo, Emiliano, Lu, Yen-Shen, Hamilton, Erika, Forero-Torres, Andres, Bachelot, Thomas, Maur, Michela, Fasolo, Angelica, Tiedt, Ralph, Nardi, Lisa, Stammberger, Uz, Abdelhady, Ahmed M, Ruan, Shiling, Lee, Soo Chin

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