Analysis of the Inhibition and Remodeling of Islet Amyloid Polypeptide Amyloid Fibers by Flavanols von Cao, Ping, Raleigh, Daniel P

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A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides von Abedini, Andisheh, Raleigh, Daniel P.

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Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction von Muir, Tom W, Fierz, Beat, Chatterjee, Champak, McGinty, Robert K, Bar-Dagan, Maya, Raleigh, Daniel P

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Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors von Young, Lydia M, Cao, Ping, Raleigh, Daniel P, Ashcroft, Alison E, Radford, Sheena E

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Linking Gas-Phase and Solution-Phase Protein Unfolding via Mobile Proton Simulations von Eldrid, Charles, Cragnolini, Tristan, Ben-Younis, Aisha, Zou, Junjie, Raleigh, Daniel P., Thalassinos, Konstantinos

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On the plasticity of amyloid formation: The impact of destabilizing small to large substitutions on islet amyloid polypeptide amyloid formation von Manathunga, Lakshan, Akter, Rehana, Zhyvoloup, Alexander, Simmerling, Carlos, Raleigh, Daniel P.

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Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry von Young, Lydia M., Saunders, Janet C., Mahood, Rachel A., Revill, Charlotte H., Foster, Richard J., Tu, Ling-Hsien, Raleigh, Daniel P., Radford, Sheena E., Ashcroft, Alison E.

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Ionic Strength Effects on Amyloid Formation by Amylin Are a Complicated Interplay among Debye Screening, Ion Selectivity, and Hofmeister Effects von Marek, Peter J, Patsalo, Vadim, Green, David F, Raleigh, Daniel P

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Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet von Buchanan, Lauren E., Dunkelberger, Emily B., Tran, Huong Q., Cheng, Pin-Nan, Chiu, Chi-Cheng, Cao, Ping, Raleigh, Daniel P., de Pablo, Juan J., Nowick, James S., Zanni, Martin T.

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Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence von Zraika, S, Hull, R. L, Verchere, C. B, Clark, A, Potter, K. J, Fraser, P. E, Raleigh, D. P, Kahn, S. E

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The Role of His-18 in Amyloid Formation by Human Islet Amyloid Polypeptide von Abedini, Andisheh, Raleigh, Daniel P

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A role for helical intermediates in amyloid formation by natively unfolded polypeptides? von Abedini, Andisheh, Raleigh, Daniel P

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Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics von Abedini, Andisheh, Plesner, Annette, Cao, Ping, Ridgway, Zachary, Zhang, Jinghua, Tu, Ling-Hsien, Middleton, Chris T, Chao, Brian, Sartori, Daniel J, Meng, Fanling, Wang, Hui, Wong, Amy G, Zanni, Martin T, Verchere, C Bruce, Raleigh, Daniel P, Schmidt, Ann Marie

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Experiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structure von Meng, Wenli, Lyle, Nicholas, Luan, Bowu, Raleigh, Daniel P., Pappu, Rohit V.

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Rational design of potent domain antibody inhibitors of amyloid fibril assembly von Ladiwala, Ali Reza A, Bhattacharya, Moumita, Perchiacca, Joseph M, Cao, Ping, Raleigh, Daniel P, Abedini, Andisheh, Schmidt, Ann Marie, Varkey, Jobin, Langen, Ralf, Tessier, Peter M

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Deamidation Accelerates Amyloid Formation and Alters Amylin Fiber Structure von Dunkelberger, Emily B, Buchanan, Lauren E, Marek, Peter, Cao, Ping, Raleigh, Daniel P, Zanni, Martin T

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Islet Amyloid Deposition Limits the Viability of Human Islet Grafts but Not Porcine Islet Grafts von Potter, K. J., Abedini, A., Marek, P., Klimek, A. M., Butterworth, S., Driscoll, M., Baker, R., Nilsson, M. R., Warnock, G. L., Oberholzer, J., Bertera, S., Trucco, M., Korbutt, G. S., Fraser, P. E., Raleigh, D. P., Verchere, C. B., Steiner, Donald F.

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Strategies for Extracting Structural Information from 2D IR Spectroscopy of Amyloid: Application to Islet Amyloid Polypeptide von Strasfeld, David B, Ling, Yun L, Gupta, Ruchi, Raleigh, Daniel P, Zanni, Martin T

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Efficient Microwave-Assisted Synthesis of Human Islet Amyloid Polypeptide Designed to Facilitate the Specific Incorporation of Labeled Amino Acids von Marek, Peter, Woys, Ann Marie, Sutton, Kelvin, Zanni, Martin T, Raleigh, Daniel P

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Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics von Taskent-Sezgin, Humeyra, Chung, Juah, Banerjee, Partha S, Nagarajan, Sureshbabu, Dyer, R. Brian, Carrico, Isaac, Raleigh, Daniel P

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