Cross-reactivity and clinical impact of the antibody response to hepatitis C virus second envelope glycoprotein (E2) von Hadlock, Kenneth G., Gish, Robert, Rowe, Judy, Rajyaguru, Sonal S., Newsom, Margaret, Warford, Ann, Foung, Steven K.H.

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Expression of the simian epstein-barr virus-encoded latent membrane protein-1 in malignant lymphomas of SIV-infected rhesus macaques von Blaschke, Sabine, Hannig, Horst, Buske, Christian, Kaup, Franz-J., Hunsmann, Gerhard, Bodemer, Walter

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GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796 von McCown, Matthew F, Rajyaguru, Sonal, Kular, Simran, Cammack, Nick, Nájera, Isabel

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The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors von MCCOWN, Matthew F, RAJYAGURU, Sonal, LE POGAM, Sophie, ALI, Samir, JIANG, Wen-Rong, KANG, Hyunsoon, SYMONS, Julian, CAMMACK, Nick, NAJERA, Isabel

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In vitro selection of resistance to sofosbuvir in HCV replicons of genotype-1 to -6 von Xu, Simin, Doehle, Brian, Rajyaguru, Sonal, Han, Bin, Barauskas, Ona, Feng, Joy, Perry, Jason, Dvory-Sobol, Hadas, Svarovskaia, Evguenia S, Miller, Michael D, Mo, Hongmei

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In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance von Le Pogam, Sophie, Jiang, Wen-Rong, Leveque, Vincent, Rajyaguru, Sonal, Ma, Han, Kang, Hyunsoon, Jiang, Sharon, Singer, Margaret, Ali, Samir, Klumpp, Klaus, Smith, Dave, Symons, Julian, Cammack, Nick, Nájera, Isabel

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Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus von Hang, Julie Qi, Yang, Yanli, Harris, Seth F., Leveque, Vincent, Whittington, Hannah J., Rajyaguru, Sonal, Ao-Ieong, Gloria, McCown, Matthew F., Wong, April, Giannetti, Anthony M., Le Pogam, Sophie, Talamás, Francisco, Cammack, Nick, Nájera, Isabel, Klumpp, Klaus

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Existence of hepatitis C virus NS5B variants naturally resistant to non-nucleoside, but not to nucleoside, polymerase inhibitors among untreated patients von Le Pogam, Sophie, Seshaadri, Amritha, Kosaka, Alan, Chiu, Sophie, Kang, Hyunsoon, Hu, Steven, Rajyaguru, Sonal, Symons, Julian, Cammack, Nick, Nájera, Isabel

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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus von LE POGAM, Sophie, KANG, Hyunsoon, HENDRICKS, Than, KLUMPP, Klaus, SYMONS, Julian, BROWNER, Michelle F, CAMMACK, Nick, NAJERA, Isabel, HARRIS, Seth F, LEVEQUE, Vincent, GIANNETTI, Anthony M, ALI, Samir, JIANG, Wen-Rong, RAJYAGURU, Sonal, TAVARES, Gisele, OSHIRO, Connie

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Discovery of N‑[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo‑1H‑pyridin-3-yl)-3-quinolyl]phenyl]­methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polym... von Talamas, Francisco X., Abbot, Sarah C., Anand, Shalini, Brameld, Ken A., Carter, David S., Chen, Jun, Davis, Dana, de Vicente, Javier, Fung, Amy D., Gong, Leyi, Harris, Seth F., Inbar, Petra, Labadie, Sharada S., Lee, Eun K., Lemoine, Remy, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, McIntosh, Joel, Nájera, Isabel, Park, Jaehyeon, Railkar, Aruna, Rajyaguru, Sonal, Sangi, Michael, Schoenfeld, Ryan C., Staben, Leanna R., Tan, Yunchou, Taygerly, Joshua P., Villaseñor, Armando G., Weller, Paul E.

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First Example of Phosphoramidate Approach Applied to a 4‘-Substituted Purine Nucleoside (4‘-Azidoadenosine):  Conversion of an Inactive Nucleoside to a Submicromolar Compound versu... von Perrone, Plinio, Daverio, Felice, Valente, Rocco, Rajyaguru, Sonal, Martin, Joseph A, Lévêque, Vincent, Pogam, Sophie Le, Najera, Isabel, Klumpp, Klaus, Smith, David B, McGuigan, Christopher

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Modulation of alpha interferon anti-hepatitis C virus activity by ISG15 von Chua, Pong Kian, McCown, Matthew F, Rajyaguru, Sonal, Kular, Simran, Varma, Ram, Symons, Julian, Chiu, Sophie S, Cammack, Nick, Najera, Isabel

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Application of the Phosphoramidate ProTide Approach to 4‘-Azidouridine Confers Sub-micromolar Potency versus Hepatitis C Virus on an Inactive Nucleoside von Perrone, Plinio, Luoni, Giovanna M, Kelleher, Mary Rose, Daverio, Felice, Angell, Annette, Mulready, Sinead, Congiatu, Costantino, Rajyaguru, Sonal, Martin, Joseph A, Levêque, Vincent, Le Pogam, Sophie, Najera, Isabel, Klumpp, Klaus, Smith, David B, McGuigan, Christopher

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The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-... von Smith, David B, Kalayanov, Genadiy, Sund, Christian, Winqvist, Anna, Maltseva, Tatiana, Leveque, Vincent J.-P, Rajyaguru, Sonal, Pogam, Sophie Le, Najera, Isabel, Benkestock, Kurt, Zhou, Xiao-Xiong, Kaiser, Ann C, Maag, Hans, Cammack, Nick, Martin, Joseph A, Swallow, Steven, Johansson, Nils Gunnar, Klumpp, Klaus, Smith, Mark

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Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors von Yang, Hanbiao, Hendricks, Robert T., Arora, Nidhi, Nitzan, Dov, Yee, Calvin, Lucas, Matthew C., Yang, Yanli, Fung, Amy, Rajyaguru, Sonal, Harris, Seth F., Leveque, Vincent J.P., Hang, Julie Q., Pogam, Sophie Le, Reuter, Deborah, Tavares, Gisele A.

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2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups von Klumpp, Klaus, Kalayanov, Genadiy, Ma, Han, Le Pogam, Sophie, Leveque, Vincent, Jiang, Wen-Rong, Inocencio, Nicole, De Witte, Anniek, Rajyaguru, Sonal, Tai, Ezra, Chanda, Sushmita, Irwin, Michael R., Sund, Christian, Winqist, Anna, Maltseva, Tatiana, Eriksson, Staffan, Usova, Elena, Smith, Mark, Alker, Andre, Najera, Isabel, Cammack, Nick, Martin, Joseph A., Johansson, Nils Gunnar, Smith, David B.

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Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B von Schoenfeld, Ryan C, Bourdet, David L, Brameld, Ken A, Chin, Elbert, de Vicente, Javier, Fung, Amy, Harris, Seth F, Lee, Eun K, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, Lui, Alfred S.-T, Najera, Isabel, Rajyaguru, Sonal, Sangi, Michael, Steiner, Sandra, Talamas, Francisco X, Taygerly, Joshua P, Zhao, Junping

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The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479) von McGuigan, Christopher, Kelleher, Mary Rose, Perrone, Plinio, Mulready, Sinead, Luoni, Giovanna, Daverio, Felice, Rajyaguru, Sonal, Pogam, Sophie Le, Najera, Isabel, Martin, Joseph A., Klumpp, Klaus, Smith, David B.

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Development and characterization of a replicon-based phenotypic assay for assessing HCV NS4B from clinical isolates von Rajyaguru, Sonal, Yang, Huiling, Martin, Ross, Miller, Michael D., Mo, Hongmei

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3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase von Hendricks, Robert T., Spencer, Stacey R., Blake, James F., Fell, Jay B., Fischer, John P., Stengel, Peter J., Leveque, Vincent J.P., LePogam, Sophie, Rajyaguru, Sonal, Najera, Isabel, Josey, John A., Swallow, Steven

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