Predicting Drug–Drug Interactions Between Rifampicin and Long-Acting Cabotegravir and Rilpivirine Using Physiologically Based Pharmacokinetic Modeling von Rajoli, Rajith K R, Curley, Paul, Chiong, Justin, Back, David, Flexner, Charles, Owen, Andrew, Siccardi, Marco

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Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5′-triphosphate exposure to support posology for SARS-CoV-2 von Pertinez, Henry, Rajoli, Rajith K R, Khoo, Saye H, Owen, Andrew

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Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation von Curley, Paul, Rajoli, Rajith K R, Moss, Darren M, Liptrott, Neill J, Letendre, Scott, Owen, Andrew, Siccardi, Marco

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Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters von Neary, Megan, Sharp, Joanne, Gallardo-Toledo, Eduardo, Herriott, Joanne, Kijak, Edyta, Bramwell, Chloe, Cox, Helen, Tatham, Lee, Box, Helen, Curley, Paul, Arshad, Usman, Rajoli, Rajith K. R., Pertinez, Henry, Valentijn, Anthony, Dhaliwal, Kevin, Mc Caughan, Frank, Hobson, James, Rannard, Steve, Kipar, Anja, Stewart, James P., Owen, Andrew

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Predicting Pharmacokinetics of a Tenofovir Alafenamide Subcutaneous Implant Using Physiologically Based Pharmacokinetic Modelling von Rajoli, Rajith K. R., Demkovich, Zach R., Flexner, Charles, Owen, Andrew, Siccardi, Marco

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Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters von Gallardo-Toledo, Eduardo, Neary, Megan, Sharp, Joanne, Herriott, Joanne, Kijak, Edyta, Bramwell, Chloe, Curley, Paul, Arshad, Usman, Pertinez, Henry, Rajoli, Rajith K R, Valentijn, Anthony, Cox, Helen, Tatham, Lee, Kipar, Anja, Stewart, James P, Owen, Andrew

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Physiologically Based Pharmacokinetic Modelling of Cabotegravir Microarray Patches in Rats and Humans von Kinvig, Hannah, Rajoli, Rajith K R, Pertinez, Henry, Vora, Lalitkumar K, Volpe-Zanutto, Fabiana, Donnelly, Ryan F, Rannard, Steve, Flexner, Charles, Siccardi, Marco, Owen, Andrew

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Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK von Rajoli, Rajith K.R., Flexner, Charles, Chiong, Justin, Owen, Andrew, Donnelly, Ryan F., Larrañeta, Eneko, Siccardi, Marco

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Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection von Hobson, James J., Savage, Alison C., Dwyer, Andrew B., Unsworth, Catherine, Massam, Jonathan, Arshad, Usman, Pertinez, Henry, Box, Helen, Tatham, Lee, Rajoli, Rajith K. R., Neary, Megan, Sharp, Joanne, Valentijn, Anthony, David, Christopher, Curley, Paul, Liptrott, Neill J., McDonald, Tom O., Owen, Andrew, Rannard, Steve P.

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The Current Landscape of Novel Formulations and the Role of Mathematical Modeling in Their Development von Cottura, Nicolas, Howarth, Alice, Rajoli, Rajith K.R., Siccardi, Marco

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Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV von Rajoli, Rajith K. R., Back, David J., Rannard, Steve, Freel Meyers, Caren L., Flexner, Charles, Owen, Andrew, Siccardi, Marco

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In Silico Dose Prediction for Long-Acting Rilpivirine and Cabotegravir Administration to Children and Adolescents von Rajoli, Rajith K. R., Back, David J., Rannard, Steve, Meyers, Caren Freel, Flexner, Charles, Owen, Andrew, Siccardi, Marco

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Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2? von Stachulski, Andrew V, Taujanskas, Joshua, Pate, Sophie L, Rajoli, Rajith K. R, Aljayyoussi, Ghaith, Pennington, Shaun H, Ward, Stephen A, Hong, Weiqian David, Biagini, Giancarlo A, Owen, Andrew, Nixon, Gemma L, Leung, Suet C, O’Neill, Paul M

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Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells von Sacramento, Carolina Q, Fintelman-Rodrigues, Natalia, Dias, Suelen S G, Temerozo, Jairo R, Da Silva, Aline de Paula D, da Silva, Carine S, Blanco, Camilla, Ferreira, André C, Mattos, Mayara, Soares, Vinicius C, Pereira-Dutra, Filipe, Miranda, Milene Dias, Barreto-Vieira, Debora F, da Silva, Marcos Alexandre N, Santos, Suzana S, Torres, Mateo, Chaves, Otávio Augusto, Rajoli, Rajith K R, Paccanaro, Alberto, Owen, Andrew, Bou-Habib, Dumith Chequer, Bozza, Patrícia T, Souza, Thiago Moreno L

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An Open Label, Adaptive, Phase 1 Trial of High‐Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS‐CoV‐2 von Walker, Lauren E., FitzGerald, Richard, Saunders, Geoffrey, Lyon, Rebecca, Fisher, Michael, Martin, Karen, Eberhart, Izabela, Woods, Christie, Ewings, Sean, Hale, Colin, Rajoli, Rajith K. R., Else, Laura, Dilly‐Penchala, Sujan, Amara, Alieu, Lalloo, David G., Jacobs, Michael, Pertinez, Henry, Hatchard, Parys, Waugh, Robert, Lawrence, Megan, Johnson, Lucy, Fines, Keira, Reynolds, Helen, Rowland, Timothy, Crook, Rebecca, Okenyi, Emmanuel, Byrne, Kelly, Mozgunov, Pavel, Jaki, Thomas, Khoo, Saye, Owen, Andrew, Griffiths, Gareth, Fletcher, Thomas E.

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Prioritization of Anti‐SARS‐Cov‐2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics von Arshad, Usman, Pertinez, Henry, Box, Helen, Tatham, Lee, Rajoli, Rajith K. R., Curley, Paul, Neary, Megan, Sharp, Joanne, Liptrott, Neill J., Valentijn, Anthony, David, Christopher, Rannard, Steve P., O’Neill, Paul M., Aljayyoussi, Ghaith, Pennington, Shaun H., Ward, Stephen A., Hill, Andrew, Back, David J., Khoo, Saye H., Bray, Patrick G., Biagini, Giancarlo A., Owen, Andrew

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Prediction of dolutegravir pharmacokinetics and dose optimization in neonates via physiologically based pharmacokinetic (PBPK) modelling von Bunglawala, Fazila, Rajoli, Rajith K R, Mirochnick, Mark, Owen, Andrew, Siccardi, Marco

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Physiologically‐Based Pharmacokinetic Modeling for Optimal Dosage Prediction of Quinine Coadministered With Ritonavir‐Boosted Lopinavir von Saeheng, Teerachat, Na‐Bangchang, Kesara, Siccardi, Marco, Rajoli, Rajith K.R., Karbwang, Juntra

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In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19 von Sacramento, Carolina Q, Fintelman-Rodrigues, Natalia, Temerozo, Jairo R, Da Silva, Aline de Paula Dias, Dias, Suelen da Silva Gomes, da Silva, Carine dos Santos, Ferreira, André C, Mattos, Mayara, Pão, Camila R R, de Freitas, Caroline S, Soares, Vinicius Cardoso, Hoelz, Lucas Villas Bôas, Fernandes, Tácio Vinício Amorim, Branco, Frederico Silva Castelo, Bastos, Mônica Macedo, Boechat, Núbia, Saraiva, Felipe B, Ferreira, Marcelo Alves, Jockusch, Steffen, Wang, Xuanting, Tao, Chuanjuan, Chien, Minchen, Xie, Wei, Patel, Dinshaw, Garzia, Aitor, Tuschl, Thomas, Russo, James J, Rajoli, Rajith K R, Pedrosa, Carolina S G, Vitória, Gabriela, Souza, Letícia R Q, Goto-Silva, Livia, Guimarães, Marilia Zaluar, Rehen, Stevens K, Owen, Andrew, Bozza, Fernando A, Bou-Habib, Dumith Chequer, Ju, Jingyue, Bozza, Patrícia T, Souza, Thiago Moreno L

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Using mechanistic physiologically-based pharmacokinetic models to assess prenatal drug exposure: Thalidomide versus efavirenz as case studies von Atoyebi, Shakir Adeyinka, Rajoli, Rajith K.R., Adejuyigbe, Ebunoluwa, Owen, Andrew, Bolaji, Oluseye, Siccardi, Marco, Olagunju, Adeniyi

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