IDDF2023-ABS-0224 Evaluating the changing trends in hepatocellular carcinoma cases in a multi-cultural australian tertiary hospital von McNamara, Jack, Joseph, Raji, Stratton, Elisabeth, Levy, Miriam, Prakoso, Emilia

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Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases von Chopra, Nikita, Wales, Thomas E, Joseph, Raji E, Boyken, Scott E, Engen, John R, Jernigan, Robert L, Andreotti, Amy H

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Screening and Characterization of Allosteric Small Molecules Targeting Bruton’s Tyrosine Kinase von Kueffer, Lauren E., Lin, David Yin-wei, Amatya, Neha, Serrenho, Joseph, Joseph, Raji E., Courtney, Adam H., Andreotti, Amy H.

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Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response von Andreotti, Amy H, Joseph, Raji E, Conley, James M, Iwasa, Janet, Berg, Leslie J

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Differential impact of BTK active site inhibitors on the conformational state of full-length BTK von Joseph, Raji E, Amatya, Neha, Fulton, D Bruce, Engen, John R, Wales, Thomas E, Andreotti, Amy

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Exploring 2‑Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story von Moraru, Ruxandra, Valle-Argos, Beatriz, Minton, Annabel, Buermann, Lara, Pan, Suyin, Wales, Thomas E., Joseph, Raji E., Andreotti, Amy H., Strefford, Jonathan C., Packham, Graham, Baud, Matthias G. J.

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The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance von Joseph, Raji E., Lowe, Jacques, Fulton, D. Bruce, Engen, John R., Wales, Thomas E., Andreotti, Amy H.

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Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts von Joseph, Raji E., Wales, Thomas E., Fulton, D. Bruce, Engen, John R., Andreotti, Amy H.

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Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases von Amatya, Neha, Wales, Thomas E., Kwon, Annie, Yeung, Wayland, Joseph, Raji E., Fulton, D. Bruce, Kannan, Natarajan, Engen, John R., Andreotti, Amy H.

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T-cell signaling regulated by the Tec family kinase, Itk von Andreotti, Amy H, Schwartzberg, Pamela L, Joseph, Raji E, Berg, Leslie J

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An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition von Devkota, Sujan, Joseph, Raji E, Boyken, Scott E, Fulton, D. Bruce, Andreotti, Amy H

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Conformational switches that control the TEC kinase – PLCγ signaling axis von Lowe, Jacques, Joseph, Raji E., Andreotti, Amy H.

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Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK von Kueffer, Lauren E., Joseph, Raji E., Andreotti, Amy H.

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Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation von Devkota, Sujan, Joseph, Raji E., Min, Lie, Bruce Fulton, D., Andreotti, Amy H.

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Identification of an Allosteric Signaling Network within Tec Family Kinases von Joseph, Raji E., Xie, Qian, Andreotti, Amy H.

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Dynamics of the Tec‐family tyrosine kinase SH3 domains von Roberts, Justin M., Tarafdar, Sreya, Joseph, Raji E., Andreotti, Amy H., Smithgall, Thomas E., Engen, John R., Wales, Thomas E.

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Substrate Recognition of PLCγ1 via a Specific Docking Surface on Itk von Xie, Qian, Joseph, Raji E., Fulton, D. Bruce, Andreotti, Amy H.

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Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia von Joseph, Raji E, Wales, Thomas E, Jayne, Sandrine, Britton, Robert G, Fulton, D Bruce, Engen, John R, Dyer, Martin J S, Andreotti, Amy H

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Bacterial expression and purification of Interleukin-2 Tyrosine kinase: Single step separation of the chaperonin impurity von Joseph, Raji E., Andreotti, Amy H.

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Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases von Joseph, Raji E, Kleino, Iivari, Wales, Thomas E, Xie, Qian, Fulton, D Bruce, Engen, John R, Berg, Leslie J, Andreotti, Amy H

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