Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts von Deshpande, Rajashree A., Lee, Ji-Hoon, Arora, Sucheta, Paull, Tanya T.

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Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes von Hoa, Nguyen Ngoc, Shimizu, Tsubasa, Zhou, Zhong Wei, Wang, Zhao-Qi, Deshpande, Rajashree A., Paull, Tanya T., Akter, Salma, Tsuda, Masataka, Furuta, Ryohei, Tsutsui, Ken, Takeda, Shunichi, Sasanuma, Hiroyuki

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Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection von Makharashvili, Nodar, Tubbs, Anthony T., Yang, Soo-Hyun, Wang, Hailong, Barton, Olivia, Zhou, Yi, Deshpande, Rajashree A., Lee, Ji-Hoon, Lobrich, Markus, Sleckman, Barry P., Wu, Xiaohua, Paull, Tanya T.

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ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis von Paiano, Jacob, Wu, Wei, Yamada, Shintaro, Sciascia, Nicholas, Callen, Elsa, Paola Cotrim, Ana, Deshpande, Rajashree A., Maman, Yaakov, Day, Amanda, Paull, Tanya T., Nussenzweig, André

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Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice von Deshpande, Rajashree A., Marin-Gonzalez, Alberto, Barnes, Hannah K., Woolley, Phillip R., Ha, Taekjip, Paull, Tanya T.

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Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites von Deshpande, Rajashree A, Lee, Ji-Hoon, Paull, Tanya T

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Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex von Lee, Ji-Hoon, Mand, Michael R., Deshpande, Rajashree A., Kinoshita, Eri, Yang, Soo-Hyun, Wyman, Claire, Paull, Tanya T.

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Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes von Hoa, Nguyen Ngoc, Shimizu, Tsubasa, Zhou, Zhong Wei, Wang, Zhao-Qi, Deshpande, Rajashree A., Paull, Tanya T., Akter, Salma, Tsuda, Masataka, Furuta, Ryohei, Tsutsui, Ken, Takeda, Shunichi, Sasanuma, Hiroyuki

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TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11 von Jeong, Hyeongsun, Wie, Minwoo, Baek, In-Joon, Sohn, Gyuwon, Um, Si-Hyeon, Lee, Seon-Gyeong, Seo, Yuri, Ra, Jaesun, Lee, Eun A, Kim, Shinseog, Kim, Byung Gyu, Deshpande, Rajashree A, Paull, Tanya T, Han, Joo Seok, Kwon, Taejoon, Myung, Kyungjae

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Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair von Myler, Logan R., Gallardo, Ignacio F., Soniat, Michael M., Deshpande, Rajashree A., Gonzalez, Xenia B., Kim, Yoori, Paull, Tanya T., Finkelstein, Ilya J.

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The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes von Paull, Tanya T., Deshpande, Rajashree A.

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ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling von Deshpande, Rajashree A, Williams, Gareth J, Limbo, Oliver, Williams, R Scott, Kuhnlein, Jeff, Lee, Ji-Hoon, Classen, Scott, Guenther, Grant, Russell, Paul, Tainer, John A, Paull, Tanya T

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Genetic Separation of Sae2 Nuclease Activity from Mre11 Nuclease Functions in Budding Yeast von Arora, Sucheta, Deshpande, Rajashree A., Budd, Martin, Campbell, Judy, Revere, America, Zhang, Xiaoming, Schmidt, Kristina H., Paull, Tanya T.

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METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma von Zeng, Xiangyu, Zhao, Fei, Cui, Gaofeng, Zhang, Yong, Deshpande, Rajashree A, Chen, Yuping, Deng, Min, Kloeber, Jake A, Shi, Yu, Zhou, Qin, Zhang, Chao, Hou, Jing, Kim, Wootae, Tu, Xinyi, Yan, Yuanliang, Xu, Zhijie, Chen, Lifeng, Gao, Huanyao, Guo, Guijie, Liu, Jiaqi, Zhu, Qian, Cao, Yueyu, Huang, Jinzhou, Wu, Zheming, Zhu, Shouhai, Yin, Ping, Luo, Kuntian, Mer, Georges, Paull, Tanya T, Yuan, Jian, Tao, Kaixiong, Lou, Zhenkun

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Characterization of DNA-PK-Bound End Fragments Using GLASS-ChIP von Deshpande, Rajashree A., Paull, Tanya T.

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Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex von Myler, Logan R., Soniat, Michael M., Zhang, Xiaoming, Deshpande, Rajashree A., Paull, Tanya T., Finkelstein, Ilya J.

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Characterization of DNA-PK-bound end fragments using GLASS-ChIP von Deshpande, Rajashree A, Paull, Tanya T

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EXD2 promotes homologous recombination by facilitating DNA end resection von Broderick, Ronan, Nieminuszczy, Jadwiga, Baddock, Hannah T., Deshpande, Rajashree A., Gileadi, Opher, Paull, Tanya T., McHugh, Peter J., Niedzwiedz, Wojciech

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The Role of Yeast DNA 3′-Phosphatase Tpp1 and Rad1/Rad10 Endonuclease in Processing Spontaneous and Induced Base Lesions von Karumbati, Anandi S., Deshpande, Rajashree A., Jilani, Arshad, Vance, John R., Ramotar, Dindial, Wilson, Thomas E.

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Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4 von Deshpande, Rajashree A., Wilson, Thomas E.

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