Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma von Hasipek, Metis, Grabowski, Dale, Guan, Yihong, Alugubelli, Raghunandan Reddy, Tiwari, Anand D., Gu, Xiaorong, DeAvila, Gabriel A., Silva, Ariosto S., Meads, Mark B., Parker, Yvonne, Lindner, Daniel J., Saunthararajah, Yogen, Shain, Kenneth H., Maciejewski, Jaroslaw P., Reu, Frederic J., Phillips, James G., Jha, Babal K.

Volltext

A pharmacodynamic model of clinical synergy in multiple myeloma von Sudalagunta, Praneeth, Silva, Maria C., Canevarolo, Rafael R., Alugubelli, Raghunandan Reddy, DeAvila, Gabriel, Tungesvik, Alexandre, Perez, Lia, Gatenby, Robert, Gillies, Robert, Baz, Rachid, Meads, Mark B., Shain, Kenneth H., Silva, Ariosto S.

Volltext

Single Cell RNA Sequencing of Sequential Samples before and after BCMA-Directed CAR-T Reveal Features Associated with Non-Durable Response, Exhausted T-Cells and Decreased Expressi... von Freeman, Ciara Louise L., Zhao, Xiaohong, Meads, Mark B, Noble, Jerald, Alugubelli, Raghunandan Reddy, Renatino-Canevarolo, Rafael, Hampton, Oliver, Sudalagunta, Praneeth Reddy, Siqueira Silva, Ariosto, Baz, Rachid, Alsina, Melissa, Hansen, Doris K., Song, Xiaofei, Shain, Kenneth H.

Volltext

Ex Vivo Mathematical Myeloma Advisor (EMMA) - a Clinical, Molecular, and Phenotypic Platform to Tailor Personalized Therapeutic Strategies for Multiple Myeloma von Renatino-Canevarolo, Rafael, Silva, Maria, Meads, Mark B, Zhao, Xiaohong, Achille, Alexandra, Noyes, David, Sudalagunta, Praneeth Reddy, Alugubelli, Raghunandan Reddy, Lastorino, Daniel, Tordesillas, Leticia, Gomez Fontela, Miguel, Hampton, Oliver, Abate-Daga, Daniel, Shain, Kenneth H., Siqueira Silva, Ariosto

Volltext

A Multiomic Approach to Reversing Therapy Resistance in Multiple Myeloma Using Paired Ex Vivo Drug Sensitivity Measures and RNA Sequencing Data von Sudalagunta, Praneeth Reddy, Meads, Mark B., Renatino-Canevarolo, Rafael, Coelho Siqueira Silva, Maria L., Zhao, Xiaohong, Waldron, Rhett, Cubitt, Christopher, Alugubelli, Raghunandan Reddy, De Avila, Gabriel, Hampton, Oliver, Gatenby, Robert, Baz, Rachid C., Shain, Kenneth H., Siqueira Silva, Ariosto

Volltext

Multiple Myeloma Evolution Is Characterized By Dynamic Epigenetic Landscapes von Renatino-Canevarolo, Rafael, Meads, Mark B., Coelho Siqueira Silva, Maria L., Sudalagunta, Praneeth Reddy, Cubitt, Christopher, De Avila, Gabriel, Alugubelli, Raghunandan Reddy, Kulkarni, Amit, Zhang, Qi, Hampton, Oliver, Baz, Rachid C., Shain, Kenneth H., Siqueira Silva, Ariosto

Volltext

Acid Ceramidase (ASAH1) Is a Key Mediator of Drug Resistance in Refractory Multiple Myeloma von Bishop, Ryan T, Li, Tao, Alugubelli, Raghunandan Reddy, Meads, Mark, Fang, Bin, De Avila, Gabriel, Hampton, Oliver, Grant, Steven, Koomen, John M., Siqueira Silva, Ariosto, Shain, Kenneth H., Lynch, Conor

Volltext

Expression of Cell Surface Immunotherapy Targets across the Multiple Myeloma Disease Spectrum: Implications for Sequencing and Multi-Target Strategies von Freeman, Ciara Louise L., Menges, Meghan, Noble, Jerald, Alugubelli, Raghunandan Reddy, Renatino-Canevarolo, Rafael, Hampton, Oliver, Sudalagunta, Praneeth Reddy, Corallo, Salvatore, Siqueira Silva, Ariosto, Meads, Mark B, Baz, Rachid, Alsina, Melissa, Hansen, Doris K., Nishihori, Taiga, Castaneda, Omar, Blue, Brandon, Grajales-Cruz, Ariel F., Wang, Yunfei, Hwu, Patrick, Koomen, John, Shain, Kenneth H., Locke, Frederick L.

Volltext

Selinexor Disrupts Epigenetic Programing and Modulates Immunogenicity in Multiple Myeloma von Sudalagunta, Praneeth Reddy, Renatino-Canevarolo, Rafael, Meads, Mark B, Noyes, David, Achille, Alexandra, Silva, Maria, Zhao, Xiaohong, Alugubelli, Raghunandan Reddy, Lastorino, Daniel, Hampton, Oliver, Freeman, Ciara Louise L., Wu, Stephen, Ellero, Andrea, Peres, Lauren C., Hansen, Doris K., Mark, Tomer, Walker, Christopher J., Taverna, Pietro, Baz, Rachid, Shain, Kenneth, Siqueira Silva, Ariosto

Volltext

Abstract 1061: Characterization of synergistic selinexor combinations with dexamethasone, pomalidomide, elotuzumab, and daratumumab in primary MM cells von Sudalagunta, Praneeth Reddy, Meads, Mark B., Canevarolo, Rafael Renatino, Silva, Maria Coelho, Cubitt, Christopher, DeAvila, Gabriel, Alugubelli, Raghunandan Reddy, Logothetis, Constantine N., Kulkarni, Amit, Zhang, Qi, Hampton, Oliver, Walker, Christopher J., Landesman, Yosef, Shain, Kenneth, Silva, Ariosto Siqueira

Volltext

Characterization of Synergistic Selinexor Combinations of Dexamethasone, Pomalidomide, Elotuzumab and Daratumumab in Primary MM Samples Ex Vivo von Shain, Kenneth H., Renatino-Canevarolo, Rafael, Meads, Mark B., Sudalagunta, Praneeth Reddy, Coelho Siqueira Silva, Maria D, Cubitt, Christopher, De Avila, Gabriel, Alugubelli, Raghunandan Reddy, Kulkarni, Amit, Zhang, Qi, Hampton, Oliver, Logothetis, Constantine, Argueta, Christian, Landesman, Yosef, Siqueira Silva, Ariosto

Volltext

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma von Burger, Karen L, Fernandez, Mario R, Meads, Mark B, Sudalagunta, Praneeth, Oliveira, Paula S, Renatino Canevarolo, Rafael, Alugubelli, Raghunandan Reddy, Tungsevik, Alexandre, De Avila, Gabe, Silva, Maria, Graeter, Allison I, Dai, Hongyue A, Vincelette, Nicole D, Prabhu, Antony, Magaletti, Dario, Yang, Chunying, Li, Weimin, Kulkarni, Amit, Hampton, Oliver, Koomen, John M, Roush, William R, Monastyrskyi, Andrii, Berglund, Anders E, Silva, Ariosto S, Cleveland, John L, Shain, Kenneth H

Volltext

Racial and ethnic differences in clonal hematopoiesis, tumor markers, and outcomes of patients with multiple myeloma von Peres, Lauren C., Colin-Leitzinger, Christelle M., Teng, Mingxiang, Dutil, Julie, Alugubelli, Raghunandan R., DeAvila, Gabriel, Teer, Jamie K., Du, Dongliang, Mo, Qianxing, Siegel, Erin M., Hampton, Oliver A., Alsina, Melissa, Brayer, Jason, Blue, Brandon, Baz, Rachid, Silva, Ariosto S., Nishihori, Taiga, Shain, Kenneth H., Gillis, Nancy

Volltext

CancerCellTracker: a brightfield time-lapse microscopy framework for cancer drug sensitivity estimation von Jiang, Qibing, Sudalagunta, Praneeth, Silva, Maria C, Canevarolo, Rafael R, Zhao, Xiaohong, Ahmed, Khandakar Tanvir, Alugubelli, Raghunandan Reddy, DeAvila, Gabriel, Tungesvik, Alexandre, Perez, Lia, Gatenby, Robert A, Gillies, Robert J, Baz, Rachid, Meads, Mark B, Shain, Kenneth H, Silva, Ariosto S, Zhang, Wei

Volltext

Racial and Ethnic Differences in Clonal Hematopoiesis, Tumor Markers, and Clinical Outcomes of Patients with Multiple Myeloma von Gillis, Nancy, Peres, Lauren C, Colin-Leitzinger, Christelle M, Teng, Mingxiang, Alugubelli, Raghunandan Reddy, De Avila, Gabriel, Du, Dongliang, Siegel, Erin M, Teer, Jamie, Hampton, Oliver, Alsina, Melissa, Brayer, Jason, Blue, Brandon J., Siqueira Silva, Ariosto, Baz, Rachid, Nishihori, Taiga, Shain, Kenneth H.

Volltext

P-115: Unc-51 Like Kinase 3 protein (ULK3)-mediated autophagy is responsible for multiple myeloma resistance to chemotherapy von Tauro, Marilena, Li, Tao, Meads, Mark, Sudalagunta, Praneeth, Alugubelli, Raghunandan Reddy, Lawrence, Nicholas, Schonbrunn, Ernst, Lawrence, Harshani, Shain, Kenneth, Lynch, Conor

Volltext

Metabolic Changes Are Associated with Melphalan Resistance in Multiple Myeloma von Koomen, David C, Meads, Mark B, Magaletti, Dario M, Guingab-Cagmat, Joy D, Oliveira, Paula S, Fang, Bin, Liu, Min, Welsh, Eric A, Meke, Laurel E, Jiang, Zhijie, Hampton, Oliver A, Tungesvik, Alexandre, De Avila, Gabriel, Alugubelli, Raghunandan Reddy, Nishihori, Taiga, Silva, Ariosto S, Eschrich, Steven A, Garrett, Timothy J, Koomen, John M, Shain, Kenneth H

Volltext

Ex Vivo Drug Sensitivity and Functional Genomics Platform Identifies Novel Combinations Targeting Intrinsic and Extrinsic Apoptotic Signaling Pathways in Multiple Myeloma von Siqueira Silva, Ariosto, Renatino-Canevarolo, Rafael, Meads, Mark B., Coelho Siqueira Silva, Maria D, Sudalagunta, Praneeth Reddy, Cubitt, Christopher, De Avila, Gabriel, Alugubelli, Raghunandan Reddy, Kulkarni, Amit, Mitchell, Melissa, Dai, Hongyue, Zhang, Qi, Hampton, Oliver, Lu, Xin, Modi, Dimple A., Motwani, Monica, Harb, Jason, Ross, Jeremy A., Shain, Kenneth H.

Volltext

A CK1δ/CK1ε Regulated Metabolic Circuit Is a Therapeutic Vulnerability for Multiple Myeloma von Burger, Karen L, Meads, Mark B., Berglund, Anders, Oliveira, Paula S., Distler, Allison, Sudalagunta, Praneeth Reddy, Jacobson, Timothy, Teer, Jamie, Welsh, Eric A., Dai, Hongyue, Koomen, John M., Raghunandan Reddy, Alugubelli, De Avila, Gabriel, Tungesvik, Alexandre, Roush, William, Siqueira Silva, Ariosto, Shain, Kenneth H., Cleveland, John

Volltext

Re-Constructing and Exploiting Transcriptional Regulatory Networks in Multiple Myeloma Drug Resistance von Renatino-Canevarolo, Rafael, Sudalagunta, Praneeth Reddy, Coelho Siqueira Silva, Maria D, Meads, Mark B., Tungesvik, Alexandre, De Avila, Gabriel, Raghunandan Reddy, Alugubelli, Nong, Minerva, Teer, Jamie, Welsh, Eric A., Lwin, Tint, Kulkarni, Amit, Dai, Hongyue, Dalton, William S., Shain, Kenneth H., Siqueira Silva, Ariosto

Volltext