Revealing cytotoxic substructures in molecules using deep learning von Webel, Henry E., Kimber, Talia B., Radetzki, Silke, Neuenschwander, Martin, Nazaré, Marc, Volkamer, Andrea

Volltext

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1 von Juneja, Manisha, Kobelt, Dennis, Walther, Wolfgang, Voss, Cynthia, Smith, Janice, Specker, Edgar, Neuenschwander, Martin, Gohlke, Björn-Oliver, Dahlmann, Mathias, Radetzki, Silke, Preissner, Robert, von Kries, Jens Peter, Schlag, Peter Michael, Stein, Ulrike

Volltext

Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo von Grosskopf, Stefanie, Eckert, Chris, Arkona, Christoph, Radetzki, Silke, Böhm, Kerstin, Heinemann, Udo, Wolber, Gerhard, von Kries, Jens-Peter, Birchmeier, Walter, Rademann, Jörg

Volltext

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs von Merkert, Sylvia, Schubert, Madline, Olmer, Ruth, Engels, Lena, Radetzki, Silke, Veltman, Mieke, Scholte, Bob J., Zöllner, Janina, Pedemonte, Nicoletta, Galietta, Luis J.V., von Kries, Jens P., Martin, Ulrich

Volltext

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations von Otten, Cécile, Knox, Jessica, Boulday, Gwénola, Eymery, Mathias, Haniszewski, Marta, Neuenschwander, Martin, Radetzki, Silke, Vogt, Ingo, Hähn, Kristina, De Luca, Coralie, Cardoso, Cécile, Hamad, Sabri, Igual Gil, Carla, Roy, Peter, Albiges‐Rizo, Corinne, Faurobert, Eva, von Kries, Jens P, Campillos, Mónica, Tournier‐Lasserve, Elisabeth, Derry, W Brent, Abdelilah‐Seyfried, Salim

Volltext

Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis von Bonnekoh, Hanna, Vera, Carolina, Abad‐Perez, Angela, Radetzki, Silke, Neuenschwander, Martin, Specker, Edgar, Mahnke, Niklas Amadeus, Frischbutter, Stefan, Latz, Eicke, Nazaré, Marc, Kries, Jens v., Maurer, Marcus, Scheffel, Jörg, Krause, Karoline

Volltext

A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation von Ostrop, Jenny, Zwiggelaar, Rosalie T., Terndrup Pedersen, Marianne, Gerbe, Francois, Bosl, Korbinian, Lindholm, Havard T., Diez-Sanchez, Alberto, Parmar, Naveen, Radetzki, Silke, von Kries, Jens Peter, Jay, Philippe, Jensen, Kim B., Arrowsmith, Cheryl, Oudhoff, Menno J.

Volltext

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance von FRIEDRICH, Katrin, WIEDER, Thomas, VON HAEFEN, Clarissa, RADETZKI, Silke, JÄNICKE, Reiner, SCHULZE-OSTHOFF, Klaus, DÖRKEN, Bernd, DANIEL, Peter T

Volltext

CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors von Mucka, Patrick, Lindemann, Peter, Bosco, Bartolomeo, Willenbrock, Michael, Radetzki, Silke, Neuenschwander, Martin, Brischetto, Cristina, Peter von Kries, Jens, Nazaré, Marc, Scheidereit, Claus

Volltext

Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner von Yusenko, Maria V., Biyanee, Abhiruchi, Andersson, Mattias K., Radetzki, Silke, von Kries, Jens P., Stenman, Göran, Klempnauer, Karl-Heinz

Volltext

Inhibition Clathrin Mediated Endocytosis: Pitstop 1and Pitstop 2 Chimeras von Prichard, Kate, Chau, Ngoc, Xue, Jing, Krauss, Michael, Sakoff, Jennette A, Gilbert, Jayne, Bahnik, Claudia, Muehlbauer, Maria, Radetzki, Silke, Robinson, Phillip J, Haucke, Volker, McCluskey, Adam

Volltext

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R) von Mach, Leonard, Omran, Anahid, Bouma, Jara, Radetzki, Silke, Sykes, David A., Guba, Wolfgang, Li, Xiaoting, Höffelmeyer, Calvin, Hentsch, Axel, Gazzi, Thais, Mostinski, Yelena, Wasinska-Kalwa, Malgorzata, de Molnier, Fabio, van der Horst, Cas, von Kries, Jens Peter, Vendrell, Marc, Hua, Tian, Veprintsev, Dmitry B., Heitman, Laura H., Grether, Uwe, Nazare, Marc

Volltext

DOTA‐Based Plectin‐1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue von Gazzi, Thais, Lesina, Marina, Wang, Qinghua, Berninger, Alexandra, Radetzki, Silke, Demir, Ihsan Ekin, Kohlmann, Larissa, Meiser, Waldemar, Wilke, Sebastian, Kries, Jens Peter, Algül, Hana, Hu, Hai‐Yu, Nazare, Marc

Volltext

Inhibition Clathrin Mediated Endocytosis: Pitstop 1 and Pitstop 2 Chimeras von Prichard, Kate, Chau, Ngoc, Xue, Jing, Krauss, Michael, Sakoff, Jennette A., Gilbert, Jayne, Bahnik, Claudia, Muehlbauer, Maria, Radetzki, Silke, Robinson, Phillip J., Haucke, Volker, McCluskey, Adam

Volltext

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement von Mostinski, Yelena, Heynen, Guus J. J. E, López-Alberca, Maria Pascual, Paul, Jerome, Miksche, Sandra, Radetzki, Silke, Schaller, David, Shanina, Elena, Seyffarth, Carola, Kolomeets, Yuliya, Ziebart, Nandor, de Schryver, Judith, Oestreich, Sylvia, Neuenschwander, Martin, Roske, Yvette, Heinemann, Udo, Rademacher, Christoph, Volkamer, Andrea, von Kries, Jens Peter, Birchmeier, Walter, Nazaré, Marc

Volltext

Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition von Kücükdisli, Murat, Bel-Abed, Hassen, Cirillo, Davide, Lo, Wen-Ting, Efrém, Nina-Louisa, Horatscheck, André, Perepelittchenko, Liudmila, Prokofeva, Polina, Ehret, Theresa A. L., Radetzki, Silke, Neuenschwander, Martin, Specker, Edgar, Médard, Guillaume, Müller, Susanne, Wilhelm, Stephanie, Kuster, Bernhard, von Kries, Jens Peter, Haucke, Volker, Nazaré, Marc

Volltext

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma von Du, Jing, Neuenschwander, Martin, Yu, Yong, Däbritz, J.Henry M., Neuendorff, Nina-Rosa, Schleich, Kolja, Bittner, Aitomi, Milanovic, Maja, Beuster, Gregor, Radetzki, Silke, Specker, Edgar, Reimann, Maurice, Rosenbauer, Frank, Mathas, Stephan, Lohneis, Philipp, Hummel, Michael, Dörken, Bernd, von Kries, Jens Peter, Lee, Soyoung, Schmitt, Clemens A.

Volltext

DOTA‐Based Plectin‐1 Targeted Contrast Agent Enables Detection of Pancreatic Cancer in Human Tissue von Gazzi, Thais, Lesina, Marina, Wang, Qinghua, Berninger, Alexandra, Radetzki, Silke, Demir, Ihsan Ekin, Kohlmann, Larissa, Meiser, Waldemar, Wilke, Sebastian, Kries, Jens Peter, Algül, Hana, Hu, Hai‐Yu, Nazare, Marc

Volltext

Pentafluorosulfanyl (SF5) as a Superior F-19 Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives von Prinz, Christian, Starke, Ludger, Ramspoth, Tizian-Frank, Kerkering, Janis, Riano, Vera Martos, Paul, Jerome, Neuenschwander, Martin, Oder, Andreas, Radetzki, Silke, Adelhoefer, Siegfried, Delgado, Paula Ramos, Aravina, Mariya, Millward, Jason M., Fillmer, Ariane, Paul, Friedemann, Siffrin, Volker, Von Kries, Jens-Peter, Niendorf, Thoralf, Nazare, Marc, Waiczies, Sonia

Volltext

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity von El-Dahshan, Adeeb, Al-Gharabli, Samer I., Radetzki, Silke, Al-Tel, Taleb H., Kumar, Pradeep, Rademann, Jörg

Volltext